 |
|
|
* Published online ahead of print APOPTOSIS/CELL CYCLE
Arias E. E. and Walter J.C. (2005)
"Replication-dependent destruction of Cdt1 limits DNA
replication to a single round per cell cycle in Xenopus egg
extracts." Genes & Dev. 19(1): 114-126.
Auld, C. A. and R. F. Morrison (2006). "Evidence for Cytosolic
p27(Kip1) Ubiquitylation and Degradation during Adipocyte
Hyperplasia." Obesity 14: 2136-2144.
Burstein E., et al. (2004) "A novel role for XIAP in copper
homeostasis through regulation of MURR1." EMBO J. 23(1):
244-254.
Dai, M.-S., D. et al. (2006). "Regulation of the MDM2-p53
Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination
Mechanism." J. Biol. Chem. 281(34): 24304-24313.
Germano, S., D. et al. (2006). "Geldanamycins Trigger a Novel
Ron Degradative Pathway, Hampering Oncogenic Signaling." J.
Biol. Chem. 281: 21710-21719.
Gottifredi V., et al. (2004) "Decreased p21 Levels Are Required
for Efficient Restart of DNA Synthesis after S Phase Block." J.
Biol. Chem. 279(7): 5802-5810.
Gurova K. V., et al. (2005) "Small molecules that reactivate p53
in renal cell carcinoma reveal a NF-{kappa}B-dependent mechanism
of p53 suppression in tumors." PNAS 102(48): 17448-17453.
Hata T., et al. (2005) "Role of p21waf1/cip1 in effects of
oxaliplatin in colorectal cancer cells." Mol. Canc. Ther. 4(10):
1585-1594.
Havens, C. G., et al. (2006). "Regulation of Late G1/S Phase
Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell.
Biol. 26(12): 4701-4711
Hong, K. U., et al. (2007). "Functional Importance of the
Anaphase-Promoting Complex-Cdh1-Mediated Degradation of
TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis ."
Mol. Cell. Biol. 27(10): 3667-3681.
Kamynina, E., et al. (2007). "Regulation of Proto-Oncogenic Dbl
by Chaperone-Controlled, Ubiquitin-Mediated Degradation” Mol.
Cell. Biol. 27(5): 1809-1822.
Koshikawa N. and Takenaga K. (2005) "Hypoxia-Regulated
Expression of Attenuated Diphtheria Toxin A Fused with
Hypoxia-Inducible Factor-1Oxygen-Dependent Degradation Domain
Preferentially Induces Apoptosis of Hypoxic Cells in Solid
Tumor." Can. Res. 65(24): 11622-11630.
Liang M., et al. (2004) "Ubiquitination and Proteolysis of
Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol.
24(17): 7524-7537.
Lolkema M.P., et al. (2005) "Tumor Suppression by the von
Hippel-Lindau Protein Requires Phosphorylation of the Acidic
Domain." J. Biol. Chem. 280(23): 22205-22211.
Liu, Y., et al. (2007). "Histone H2AX Is a Mediator of
Gastrointestinal Stromal Tumor Cell Apoptosis following
Treatment with Imatinib Mesylate." Canc. Res. 67(6): 2685-2692
Maynard M. A., et al. (2005) "Human HIF-3{alpha}4 is a
dominant-negative regulator of HIF-1 and is down-regulated in
renal cell carcinoma." FASEB J 19(11): 1396-1406.
Mukai A., et al. (2008) “Dynamic regulation of ubiquitylation
and deubiquitylation at the central spindle during cytokinesis.”
J.Cell. Sci. 121: 1325-33.
Samuel, T., et al. (2006). "Distinct BIR Domains of cIAP1
Mediate Binding to and Ubiquitination of Tumor Necrosis Factor
Receptor-associated Factor 2 and Second Mitochondrial Activator
of Caspases." J. Biol. Chem. 281(2): 1080-1090.
Schmidt A., et al. (2005) "Xenopus polo-like kinase Plx1
regulates XErp1, a novel inhibitor of APC/C activity." Genes &
Dev. 19(4): 502-513.
Shirogane T., et al. (2005) "SCF-TRCP Controls Clock-dependent
Transcription via Casein Kinase 1-dependent Degradation of the
Mammalian Period-1 (Per1) Protein." J. Biol. Chem. 280(29):
26863-26872.
Uchida C., et al. (2005) "Enhanced Mdm2 activity inhibits pRB
function via ubiquitin-dependent degradation." EMBO J. 24(1):
160-169.
Watanabe N., et al.(2004) "M-phase kinases induce phospho-dependent
ubiquitination of somatic Wee1 by SCF{beta}-TrCP." PNAS 101(13):
4419-4424.
Xu Q., et al. (2004) "Bortezomib rapidly suppresses ubiquitin
thiolesterification to ubiquitin-conjugating enzymes and
inhibits ubiquitination of histones and type I inositol
1,4,5-trisphosphate receptor." Mol. Cancer Ther. 3(10):
1263-1269.
Yan C., et al. (2005) "Activating transcription factor 3, a
stress sensor, activates p53 by blocking its ubiquitination."
EMBO J. 24(13): 2425-2435.
Yang Q.-H. and Du C. (2004) "Smac/DIABLO Selectively Reduces the
Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in
HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Zhu, F., et al. (2006). "COOH-Terminal Src Kinase-Mediated c-Jun
Phosphorylation Promotes c-Jun Degradation and Inhibits Cell
Transformation." Cancer Res. 66(11): 5729-5736.
^ Top
CULLINS
Bibeau-Poirier, A., S.-P. Gravel, et al.
(2006). "Involvement of the I{kappa}B Kinase (IKK)-Related
Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin
Ligases in IFN Regulatory Factor-3 Degradation." J. Immunol.
177(8): 5059-5067.
Furukawa, M. and Xiong Y. (2005) "BTB Protein Keap1 Targets
Antioxidant Transcription Factor Nrf2 for Ubiquitination by the
Cullin 3-Roc1 Ligase." Mol. Cell. Biol. 25(1): 162-171.
Gallegos J.R., et al. (2008) “SCF TrCP1 Activates and
Ubiquitylates TAp63.” J. Biol. Chem. 283: 66-75.
Hernandez-Munoz I., et al. (2005) "From the Cover: Stable X
chromosome inactivation involves the PRC1 Polycomb complex and
requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3
ligase." PNAS 102(21): 7635-7640.
Hiramatsu, Y., K. Kitagawa, et al. (2006). "Degradation of Tob1
Mediated by SCFSkp2-Dependent Ubiquitination." Cancer Res.
66(17): 8477-8483.
Horn P. J., et al. (2005) "A Rik1-associated, cullin-dependent
E3 ubiquitin ligase is essential for heterochromatin formation."
Genes & Dev. 19(14): 1705-1714.
Ji, P., L. Goldin, et al. (2006). "Skp2 Contains a Novel Cyclin
A Binding Domain That Directly Protects Cyclin A from Inhibition
by p27Kip1." J. Biol. Chem. 281(33): 24058-24069.
Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate
Adaptor Recycling Is Required for Efficient Repression of Nrf2
by Keap1." Mol. Cell. Biol. 26(4): 1235-1244.
Pick, E., et al. (2007). "Mammalian DET1 Regulates Cul4A
Activity and Forms Stable Complexes with E2 Ubiquitin-Conjugating
Enzymes.” Mol. Cell. Biol. 27(13): 4708-4719.
Skaar, J. R., et al. (2007). "PARC and CUL7 Form Atypical Cullin
RING Ligase Complexes.” Cancer Res. 67(5): 2006-2014.
Wang W., et al. (2004) "Molecular and Biochemical
Characterization of the Skp2-Cks1 Binding Interface." J. Biol.
Chem. 279(49): 51362-51369.
^ Top
DECONJUGATING ENZYMES
Amsel A.D., et al. (2008) ‘Regulation of
the pro-apoptotic factor Bax by Ku70-dependent deubiquitylation.’
PNAS 105: 5117-22.
Avvakumov, G. V., et al. (2006). "Amino-terminal dimerization,
NRDP1 (FLRF) - rhodanese interaction, and inhibited catalytic
domain conformation of the ubiquitin specific protease 8
(USP8/UBPY)." J. Biol. Chem.281(49):38061-38070.
Barretto N., et al. (2005) "The Papain-Like Protease of Severe
Acute Respiratory Syndrome Coronavirus Has Deubiquitinating
Activity." J. Virol. 79(24): 15189-15198.
BELLARE, P., A. K. KUTACH, et al. (2006). "Ubiquitin binding by
a variant Jab1/MPN domain in the essential pre-mRNA splicing
factor Prp8p." RNA 12(2): 292-302.
Chen, Z., Y. Wang, et al. (2007). "Proteolytic Processing and
Deubiquitinating Activity of Papain-Like Proteases of Human
Coronavirus NL63." J. Virol. 81(11): 6007-6018.
Das, C., Q. Q. Hoang, et al. (2006). "Structural basis for
conformational plasticity of the Parkinson's disease-associated
ubiquitin hydrolase UCH-L1." PNAS 103(12): 4675-4680.
Gallery, M., J. L. Blank, et al. (2007). "The JAMM motif of
human deubiquitinase Poh1 is essential for cell viability." Mol.
Cancer Ther. 6(1): 262-268.
Remark, S., C. Schleicher, et al. (2007). "The large tegument
protein (ORFF) of the mouse {gamma} herpes virus MHZ-68 encodes
a functional Ubiquitin-specific protease, expressed and active
in the course of infection." J. Virol.: 81:10300-10309.
Kee, Y., et al. (2006). "The Ubp2 deubiquitinating enzyme
modulates Rsp5-dependent K63-linked polyubiquitin conjugates in
Saccharomyces cerevisiae." J. Biol. Chem. 286: 36724-36731.
Kee, Y., et al. (2006). "The Deubiquitinating Enzyme Ubp2
Modulates Rsp5-dependent Lys63-linked Polyubiquitin Conjugates
in Saccharomyces cerevisiae." J. Biol. Chem. 281(48):
36724-36731.
Koulich, E., et al. (2008) ‘Relative Structural and Functional
Roles of Multiple Deubiquitylating Proteins Associated with
Mammalian 26S Proteasome.’ Mol. Biol. Cell 19: 1072-82.
Le Negrate, G., et al. (2008) ‘Salmonella Secreted Factor L
Deubiquitinase of Salmonella typhimurium Inhibits NF-B,
Suppresses IB Ubiquitination and Modulates Innate Immune
Responses.’ J. Immunol. 180: 5045-56.
Lindner H. A., et al. (2005) "The Papain-Like Protease from the
Severe Acute Respiratory Syndrome Coronavirus is a
Deubiquitinating Enzyme." J. Virol. 79(24): 15199-15208.
Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the
Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol.
26(11): 4122-4133.
McCullough J., et al. (2004) "AMSH is an endosome-associated
ubiquitin isopeptidase." J. Cell Biol. 166(4): 487-492.
Mizuno E., et al. (2005) "Regulation of Epidermal Growth Factor
Receptor Down-Regulation by UBPY-mediated Deubiquitination at
Endosomes." Mol. Biol. Cell 16(11): 5163-5174.
Nakamura, M., N. Tanaka, et al. (2006). "Clathrin anchors
deubiquitinating enzymes, AMSH and AMSH-like protein, on early
endosomes." Genes Cells 11(6): 593-606.
Row, P. E., H. Liu, et al. (2007). "The MIT domain of UBPY
constitutes a CHMP binding and endosomal localisation signal
required for efficient EGF receptor degradation." J. Biol.
Chem.: 282:30929-30937.
Rytkonen, A., et al. (2007) "SseL, a Salmonella deubiquitinase
required for macrophage killing and virulence4." PNAS 104(9):
3502-3507.
Sakurai, M., et al. (2006) "Ubiquitin C-terminal hydrolase L1
regulates the morphology of neural progenitor cells and
modulates their differentiation." J. Cell Sci. 119(1): 162-171.
Gredmark, S., et al. (2007) "The large tegument protein (ORF64)
of the mouse {gamma} herpes virus MHV-68 encodes a functional
ubiquitin-specific protease, expressed and active in the course
of infection." J. Virol.: 81:10300-10309.
Todi, S. V., et al. (2007). "Cellular turnover of the
polyglutamine disease protein ataxin-3 is regulated by its
catalytic activity." J. Biol. Chem.: 282(40): 29348-29358.
Tzimas C, et al. (2006) "Human ubiquitin specific protease 31 is
a deubiquitinating enzyme implicated in activation of nuclear
factor-kappaB. Cell. Signal. 18(1):83-92.
Wang, J., et al. (2006). "High-Molecular-Weight Protein (pUL48)
of Human Cytomegalovirus is a Competent Deubiquitinating
Protease: Mutant Viruses Altered in its Active-Site Cysteine or
Histidine are Viable." J. Virol. 80(12): 6003-6012.
Xu, S., et al. (2007). "Substrate Recognition and Ubiquitination
of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase." J. Biol.
Chem. 282(21): 15462-15470.
Yi, Y.-J., et al. (2007). "Ubiquitin C-Terminal Hydrolase-Activity
Is Involved in Sperm Acrosomal Function and Anti-Polyspermy
Defense During Porcine Fertilization." Biol. Reprod.77:780-793.
Zhou H., et al. (2005) "Yersinia virulence factor YopJ acts as a
deubiquitinase to inhibit NF-{kappa}B activation." J. Exp. Med.
202(10): 1327-1332.
^ Top
E3 LIGASES
Abramovitch, R. B., et al. (2006). "Type
III effector AvrPtoB requires intrinsic E3 ubiquitin ligase
activity to suppress plant cell death and immunity." PNAS
103(8): 2851-2856.
Bartee E., et al. (2004) "Downregulation of Major
Histocompatibility Complex Class I by Human Ubiquitin Ligases
Related to Viral Immune Evasion Proteins." J. Virol. 78(3):
1109-1120.
Bottomley M., et al. (2005) "NMR Structure of the First PHD
Finger of Autoimmune Regulator Protein (AIRE1): Insights into
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Apeced)
Disease." J. Biol. Chem. 280(12): 11505-11512.
Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear
RING Domain Protein with Functional Connections to Chromatin
Modification in Saccharomyces cerevisiae." Mol. Cell. Biol.
27(8): 2800-2811
Burnett, B. G. and Pittman R.N. (2005) "The polyglutamine
neurodegenerative protein ataxin 3 regulates aggresome
formation." PNAS 102(12): 4330-4335.
Butler, M. P., et al. (2007). "Kinase active IRAKs promote
polyubiquitination and degradation of the Pellino family: Direct
evidence for Pellino proteins being E3 ubiquitin ligases." J.
Biol. Chem. 282:29729-29737.
Bunce, M.W., et al. (2008) “Coordinated Activation of the
Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of
Phosphatidylinositol 5-Phosphate.” J. Biol. Chem. 283:
8678-8686.
Canning, M., et al. (2004) "A RING Finger Ubiquitin Ligase Is
Protected from Autocatalyzed Ubiquitination and Degradation by
Binding to Ubiquitin-specific Protease USP7." J. Biol. Chem.
279(37): 38160-38168.
Choi, D.W., et al. (2008) “Ubiquitination and Degradation of
Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box
Protein WSB-1.” J. Biol. Chem. 283: 4682-4689.
Cooper E. M., et al. (2004) "Biochemical Analysis of Angelman
Syndrome-associated Mutations in the E3 Ubiquitin Ligase
E6-associated Protein." J. Biol. Chem. 279(39): 41208-41217.
Dasgupta A., et al. (2004) "Sir Antagonist 1 (San1) Is a
Ubiquitin Ligase." J. Biol. Chem. 279(26): 26830-26838.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces
alterations of the ubiquitin-proteasome pathway in the
diaphragm." J. Appl. Physiol. 98(4): 1314-1321.
Doss-Pepe E. W., et al. (2005) "{alpha}-Synuclein and Parkin
Contribute to the Assembly of Ubiquitin Lysine 63-linked
Multiubiquitin Chains." J. Biol. Chem. 280(17): 16619-16624.
Dul, B. E. and N. C. Walworth (2007). "The Plant Homeodomain
Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase
Activity." J. Biol. Chem. 282(25): 18397-18406.
Espinosa, A., et al. (2006). "The Sjogren's Syndrome-Associated
Auto-antigen Ro52 Is an E3 Ligase That Regulates Proliferation
and Cell Death." J. Immunol. 176(10): 6277-6285.
Fareed, M. U., et al. (2006). "Treatment of rats with calpain
inhibitors prevents sepsis-induced muscle proteolysis
independent of atrogin-1/MAFbx and MuRF1 expression." Am. J.
Physiol.Reg.Integ. Comp. Physiol. 290(6): R1589-1597.
Fortier, J. M. and J. Kornbluth (2006). "NK Lytic-Associated
Molecule, Involved in NK Cytotoxic Function, Is an E3 Ligase."
J. Immunol. 176(11): 6454-6463.
Gentry M. S., et al. (2005) "From The Cover: Insights into
Lafora disease: Malin is an E3 ubiquitin ligase that
ubiquitinates and promotes the degradation of laforin." PNAS
102(24): 8501-8506.
Guan, B., et al. (2008) “Ubiquitination by TOPORS Regulates the
Prostate Tumor Suppressor NKX3.1.” J. Biol. Chem. 283:
4834-4840.
Habelhah H., et al. (2004) "Ubiquitination and translocation of
TRAF2 is required for activation of JNK but not of p38 or
NF-B." EMBO J. 23(2): 322-332.
He, F., B. J. Fenner, et al. (2006). "White Spot Syndrome Virus
Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates
Degradation of a Host Tumor Suppressor via Ubiquitination." J.
Virol. 80(8): 3884-3892.
Hrecka, K., M. Gierszewska, et al. (2007). "Lentiviral Vpr
usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell
cycle." PNAS 104(28): 11778-11783.
Hua, Z. and T.-h. Kao (2006). "Identification and
Characterization of Components of a Putative Petunia S-Locus
F-Box-Containing E3 Ligase Complex Involved in S-RNase-Based
Self-Incompatibility." Plant Cell 18(10): 2531-2553.
Jang I.-C., et al. (2005) "HFR1 is targeted by COP1 E3 ligase
for post-translational proteolysis during phytochrome A
signaling." Genes & Dev. 19(5): 593-602.
Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of
the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion
Channels.” Mol. Biol. Cell 18(8): 3105-3118.
Kalesnikoff, J., et al. (2007). "Roles of RabGEF1/Rabex-5
domains in regulating FcRI surface expression and FcRI-dependent
responses in mast cells." Blood 109(12): 5308-5317.
Kawahara, K., et al. (2008) “-Synuclein Aggregates Interfere
with Parkin Solubility and Distribution: ROLE IN THE
PATHOGENESIS OF PARKINSON DISEASE.” J. Biol. Chem. 283:
6979-6987.
Kee Y., et al. (2005) "The Rsp5 ubiquitin ligase is coupled to
and antagonized by the Ubp2 deubiquitinating enzyme." EMBO J.
24(13): 2414-2424.
Kong, H. J., et al. (2007). "Cutting Edge: Autoantigen Ro52 Is
an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and
Enhances Cytokine Expression in Macrophages." J. Immunol.
179(1): 26-30.
Koutelou, E., et al. (2008) “Neuralized-like 1 (Neurl1) Targeted
to the Plasma Membrane by N-Myristoylation Regulates the Notch
Ligand Jagged1.” J. Biol. Chem. 283: 3846-53.
Kraft E., et al. (2005) "Genome Analysis and Functional
Characterization of the E2 and RING-Type E3 Ligase
Ubiquitination Enzymes of Arabidopsis." Plant Physiology 139(4):
1597-1611.
Kus B., et al. (2005) "A High Throughput Screen to Identify
Substrates for the Ubiquitin Ligase Rsp5." J. Biol. Chem.
280(33): 29470-29478.
Laine, A., I., et al. (2006). "Regulation of p53 Localization
and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.
Lamothe, B., et al. (2007). "Site-specific Lys-63-linked Tumor
Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination
Is a Critical Determinant of IB Kinase Activation." J. Biol.
Chem. 282(6): 4102-4112.
Lilley B. N. and Ploegh H.L (2005) "Multiprotein complexes that
link dislocation, ubiquitination, and extraction of misfolded
proteins from the endoplasmic reticulum membrane." PNAS 102(40):
14296-14301.
Liu, L-J., et al. (2008) “COP1-Mediated Ubiquitination of
CONSTANS Is Implicated in Cryptochrome Regulation of Flowering
in Arabidopsis.” Plant Cell. 20: 292-306.
Lo, S.-C. and M. Hannink (2006). "PGAM5, a Bcl-XL-interacting
protein, is a novel substrate for the redox-regulated
Keap1-dependent ubiquitin ligase complex." J. Biol. Chem.:
281:37893-37903.
Lu, Z., et al. (2007). "Regulation of synaptic growth and
maturation by a synapse-associated E3 ubiquitin ligase at the
neuromuscular junction." J. Cell Biol. 177(6): 1077-1081
Luke-Glaser, S., et al. (2007). "CIF-1, a Shared Subunit of the
COP9/Signalosome and Eukaryotic Initiation Factor 3 Complexes,
Regulates MEL-26 Levels in the Caenorhabditis elegans Embryo."
Mol. Cell. Biol. 27(12): 4526-4540.
Malakhova O.A. and Zhang D-E. (2008) “ISG15 Inhibits Nedd4
Ubiquitin E3 Activity and Enhances the Innate Antiviral
Response.” J. Biol. Chem. 283: 8783-8787.
Mansouri, M., et al. (2006). "Kaposi sarcoma herpesvirus K5
removes CD31/PECAM from endothelial cells." Blood 108(6):
1932-1940.
Marteijn J. A. F., et al. (2005) "The E3 ubiquitin-protein
ligase Triad1 inhibits clonogenic growth of primary myeloid
progenitor cells." Blood 106(13): 4114-4123.
Miyauchi, Y., et al. (2008) “The COP9/signalosome increases the
efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible
factor-alpha ubiquitination.” J. Biol. Chem. M710599200.
Miller, S. L. H., et al. (2007). "Ubiquitin-interacting Motifs
Inhibit Aggregation of PolyQ-expanded Huntingtin." J. Biol.
Chem. 282(13): 10096-10103.
Morokuma, Y., et al. (2007). "MARCH-XI, a Novel Transmembrane
Ubiquitin Ligase Implicated in Ubiquitin-dependent Protein
Sorting in Developing Spermatids." J. Biol. Chem. 282(34):
24806-24815.
Mudgil Y., et al. (2004) "A Large Complement of the Predicted
Arabidopsis ARM Repeat Proteins Are Members of the U-Box E3
Ubiquitin Ligase Family." Plant Physiology 134(1): 59-66.
Mulder, K. W., A. Inagaki, et al. (2007). "Modulation of
Ubc4p/Ubc5p-Mediated Stress Responses by the
RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in
Saccharomyces cerevisiae." Genetics 176(1): 181-192
Nelson, R. F., et al. (2006). "A Novel Route for F-box
Protein-mediated Ubiquitination Links CHIP to Glycoprotein
Quality Control." J. Biol. Chem. 281(29): 20242-20251.
Nerenberg B. T. H., et al. (2005) "The Poxviral RING Protein p28
Is a Ubiquitin Ligase That Targets Ubiquitin to Viral
Replication Factories." J. Virol. 79(1): 597-601.
Nishikawa H., et al. (2004) "Mass Spectrometric and Mutational
Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by
BRCA1-BARD1 Ubiquitin Ligase." J. Biol. Chem. 279(6): 3916-3924.
Ogawa, M., et al. (2008) “Rines/RNF180, a novel RING finger
gene-encoded product, is a membrane-bound ubiquitin ligase.”
Genes Cells 13: 397-409.
Peng H.-M., et al. (2004) "Ubiquitylation of Neuronal
Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase."
J. Biol. Chem. 279(51): 52970-52977.
Rajendra R., et al. (2004) "Topors Functions as an E3 Ubiquitin
Ligase with Specific E2 Enzymes and Ubiquitinates p53." J. Biol.
Chem. 279(35): 36440-36444.
Sangadala, S., S. D. Boden, et al. (2006). "LIM Mineralization
Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness
via a Novel Interaction with Smurf1 Resulting in Decreased
Ubiquitination of Smads." J. Biol. Chem. 281(25): 17212-17219.
Sargin, B., C. Choudhary, et al. (2007). "Flt3-dependent
transformation by inactivating c-Cbl mutations in AML." Blood
110(3): 1004-1012.
Sasaki, M., et al. (2007). "MDM2 Binding Induces a
Conformational Change in p53 That Is Opposed by Heat-shock
Protein 90 and Precedes p53 Proteasomal Degradation." J. Biol.
Chem. 282(19): 14626-14634.
Secombe J. and Parkhurst S.M. (2004) "Drosophila Topors Is a
RING Finger-containing Protein That Functions as a Ubiquitin-protein
Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor
Protein." J. Biol. Chem. 279(17): 17126-17133.
Sekine, K., et al. (2008) “Small Molecules Destabilize cIAP1 by
Activating Auto-ubiquitylation.” J. Biol. Chem. 283: 8961-8.
Starita L. M., et al. (2004) "BRCA1-Dependent Ubiquitination of
-Tubulin Regulates Centrosome Number." Mol. Cell. Biol. 24(19):
8457-8466.
Stone S. L., et al. (2005) "Functional Analysis of the RING-Type
Ubiquitin Ligase Family of Arabidopsis." Plant Physiology
137(1): 13-30.
Tatematsu, K., et al. (2008) “Identification of Ubiquitin Ligase
Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and
Protein Kinase C.” J. Biol. Chem. 283: 11575-85.
Tursun B., et al. (2005) "The ubiquitin ligase Rnf6 regulates
local LIM kinase 1 levels in axonal growth cones." Genes & Dev.
19(19): 2307-2319.
Vichi A., et al. (2005) "E3 ubiquitin ligase activity of the
trifunctional ARD1 (ADP-ribosylation factor domain protein 1)"
PNAS 102(6): 1945-1950.
Wang, X., et al. (2007). "Ubiquitination of serine, threonine,
or lysine residues on the cytoplasmic tail can induce ERAD of
MHC-I by viral E3 ligase mK3." J. Cell Biol. 177(4): 613-624.
Wang, X., et al. (2006). "The Viral E3 Ubiquitin Ligase mK3 Uses
the Derlin/p97 Endoplasmic Reticulum-associated Degradation
Pathway to Mediate Down-regulation of Major Histocompatibility
Complex Class I Proteins." J. Biol. Chem. 281(13): 8636-8644.
Wang Z., et al. (2005) "RING-H2 Protein WSSV249 from White Spot
Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme,
PvUbc, for Viral Pathogenesis." J. Virol. 79(14): 8764-8772.
Wu, W., H. Nishikawa, et al. (2007). "BRCA1 Ubiquitinates RPB8
in Response to DNA Damage." Cancer Res. 67(3): 951-958.
Worby, C.A., et al. (2008) “Malin Decreases Glycogen
Accumulation by Promoting the Degradation of Protein Targeting
to Glycogen (PTG)”. J. Biol. Chem. 283: 4069-76.
Yamada, M., J. Ohnishi, et al. (2006). "NARF, an Nemo-like
Kinase (NLK)-associated Ring Finger Protein Regulates the
Ubiquitylation and Degradation of T Cell Factor/Lymphoid
Enhancer Factor (TCF/LEF)." J. Biol. Chem. 281(30): 20749-20760.
Yao D., et al. (2004) "Nitrosative stress linked to sporadic
Parkinson's disease: S-nitrosylation of parkin regulates its E3
ubiquitin ligase activity." PNAS 101(29): 10810-10814.
Yogosawa S., et al.. (2005) "Ubiquitylation and Degradation of
Serum-inducible Kinase by hVPS18, a RING-H2 Type Ubiquitin
Ligase." J. Biol. Chem. 280(50): 41619-41627.
Zhang D. D., S, et al. (2004) "Keap1 Is a Redox-Regulated
Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase
Complex." Mol. Cell. Biol. 24(24): 10941-10953.
Zhang Y., et al. (2005) "Recognition and Ubiquitination of
Salmonella Type III Effector SopA by a Ubiquitin E3 Ligase,
HsRMA1." J. Biol. Chem. 280(46): 38682-38688.
Zhao H., et al. (2005) "A Novel E3 Ubiquitin Ligase TRAC-1
Positively Regulates T Cell Activation." J. Immunol. 174(9):
5288-5297.
Zhao, Y., et al. (2007). "Tumor Necrosis Factor Receptor 2
Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination
and Terminates Mitogen-activated Protein Kinase Signaling." J.
Biol. Chem. 282(11): 7777-7782.
^ Top
ER
TRAFFICKING/RECEPTORS/SIGNALLING
Almeida, C. G., et al. (2006). "-Amyloid
Accumulation Impairs Multivesicular Body Sorting by Inhibiting
the Ubiquitin-Proteasome System." J. Neurosci. 26(16):
4277-4288.
Barriere, H., et al. (2007). "Plasticity of Poly-Ubiquitin
Recognition as Lysosomal Targeting Signals by the Endosomal
Sorting Machinery." Mol. Biol. Cell. 18(10) :3952-3965.
Bergeron, A., et al. (2006). "Involvement of Endoplasmic
Reticulum Stress in Hereditary Tyrosinemia Type I." J. Biol.
Chem. 281(9): 5329-5334.
Chen, Y., et al. (2006). "Proteasome-dependent down-regulation
of activated Stat5A in the nucleus." Blood 108(2): 566-574.
Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3)
Mediates Ubiquitination and Degradation of Tumor Necrosis Factor
Receptor II." Mol. Cell. Biol. 25(11): 4716-4726.
Conze, D.B., et al. (2008) “Lys63-Linked Poly-ubiquitination of
IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like
Receptor-Mediated NF-B Activation.” Mol. Cell. Biol. 28:
3538-47.
Esposito, K., et al. (2006). "Rosiglitazone Cools Down
Inflammation in the Metabolic Syndrome." Arterioscler. Thromb.
Vasc. Biol. 26(6): 1413-1414.
Floyd, Z. E., B. M. Segura, et al. (2006). "Degradation of STAT5
Proteins in 3T3-L1 Adipocytes is induced by TNF{alpha} and
cycloheximide in a manner independent of STAT5A activation." Am
J Physiol Endocrinol Metab: 292(2):E461-8.
Forbes, A., et al. (2007). "The tetraspan protein EMP2 regulates
expression of caveolin-1." J. Biol. Chem.: 282(36): 26542-26551.
Fotia A. B., et al. (2004) "Regulation of Neuronal Voltage-gated
Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and
Nedd4-2." J. Biol. Chem. 279(28): 28930-28935.
Fukuda, H., et al. (2006). "MARCH-III Is a Novel Component of
Endosomes with Properties Similar to Those of MARCH-II." J.
Biochem. (Tokyo) 139(1): 137-145.
Habelhah H., et al. (2004) "Ubiquitination and translocation of
TRAF2 is required for activation of JNK but not of p38 or
NF-B." EMBO J. 23(2): 322-332.
Hatao, F., M. Muroi, et al. (2004) "Prolonged Toll-like receptor
stimulation leads to down-regulation of IRAK-4 protein." J.
Leukoc. Biol. 76(4): 904-908.
Jang, I.-C., S. W. Yang, et al. (2007). "Independent and
interdependent functions of LAF1 and HFR1 in phytochrome A
signaling." Genes & Dev. 21(16): 2100-2111.
Kaneko-Oshikawa C., et al. (2005) "Mammalian E4 Is Required for
Cardiac Development and Maintenance of the Nervous System." Mol.
Cell. Biol. 25(24): 10953-10964.
Kim, S. T., et al. (2006). "Exogenous Free Ubiquitin Enhances
Lily Pollen Tube Adhesion to an in Vitro Stylar Matrix and May
Facilitate Endocytosis of SCA (Stigma/stylar Cysteine-rich
Adhesin)." Plant Physiology: 142: 984-992.
Kim D. W., et al. (2005) "The Shigella flexneri effector OspG
interferes with innate immune responses by targeting ubiquitin-conjugating
enzymes." PNAS 102(39): 14046-14051.
Kowanetz K., et al. (2004) "Suppressors of T-cell Receptor
Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of
Receptor Tyrosine Kinases." J. Biol. Chem. 279(31): 32786-32795.
Lee T. H., et al. (2004) "The Kinase Activity of Rip1 Is Not
Required for Tumor Necrosis Factor--induced IB Kinase or p38
MAP Kinase Activation or for the Ubiquitination of Rip1 by
Traf2." J. Biol. Chem. 279(32): 33185-33191.
Lilley B. N. and Ploegh H.L. (2005) "Multiprotein complexes that
link dislocation, ubiquitination, and extraction of misfolded
proteins from the endoplasmic reticulum membrane." PNAS 102(40):
14296-14301.
Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate
Adaptor Recycling Is Required for Efficient Repression of Nrf2
by Keap1." Mol. Cell. Biol. 26(4): 1235-1244.
Mansouri, M., et al. (2006). "Kaposi sarcoma herpesvirus K5
removes CD31/PECAM from endothelial cells." Blood 108(6):
1932-1940.
Marfella, R., et al. (2006). "Increased Activity of the
Ubiquitin-Proteasome System in Patients With Symptomatic Carotid
Disease Is Associated With Enhanced Inflammation and May
Destabilize the Atherosclerotic Plaque: Effects of Rosiglitazone
Treatment." J. Am. Coll. Cardiol. 47(12): 2444-2455.
Marfella, R., M. D'Amico, et al. (2006). "The
Ubiquitin-Proteasome System and Inflammatory Activity in
Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone
Treatment." Diabetes 55(3): 622-632.
Medina E. A., et al. (2005) "Tumor Necrosis Factor- Decreases
Akt Protein Levels in 3T3-L1 Adipocytes via the
Caspase-Dependent Ubiquitination of Akt." Endocrinology 146(6):
2726-2735.
Nelson, R. F., et al. (2006). "A Novel Route for F-box
Protein-mediated Ubiquitination Links CHIP to Glycoprotein
Quality Control." J. Biol. Chem. 281(29): 20242-20251.
Ogawa S., et al. (2004) "A nuclear receptor co-repressor
transcriptional checkpoint controlling activator protein
1-dependent gene networks required for macrophage activation."
PNAS 101(40): 14461-14466.
Oved, S., Y. Mosesson, et al. (2006). "Conjugation to Nedd8
Instigates Ubiquitylation and Down-regulation of Activated
Receptor Tyrosine Kinases." J. Biol. Chem. 281(31): 21640-21651.
Shah, O. J. and T. Hunter (2006). "Turnover of the Active
Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine
Phosphorylation in Cell Culture Models of Tuberous Sclerosis."
Mol. Cell. Biol. 26(17): 6425-6434.
Song B.-L. and DeBose-Boyd R.A. (2004) "Ubiquitination of
3-Hydroxy-3-methylglutaryl-CoA Reductase in Permeabilized Cells
Mediated by Cytosolic E1 and a Putative Membrane-bound Ubiquitin
Ligase." J. Biol. Chem. 279(27): 28798-28806.
Song, B.-L. and R. A. DeBose-Boyd (2006). "Insig-dependent
Ubiquitination and Degradation of 3-Hydroxy-3-methylglutaryl
Coenzyme A Reductase Stimulated by - and -Tocotrienols." J.
Biol. Chem. 281(35): 25054-25061.
Sun, Z., S. Zhang, et al. (2007). "Keap1 Controls Post-Induction
Repression of the Nrf2-Mediated Antioxidant Response by
Escorting Nuclear Export of Nrf2." Mol. Cell. Biol.:
27(18):6334-6349.
Wang H., et al. (2004) "Both the PPPY and PTAP Motifs Are
Involved in Human T-Cell Leukemia Virus Type 1 Particle
Release." J. Virol. 78(3): 1503-1512.
Zvonic S., et al. (2005) "Cross-talk among gp130 Cytokines in
Adipocytes." J. Biol. Chem. 280(40): 33856-33863.
^ Top
PROTEASOME DEGRADATION
Adachi K., et al. (2004) "Ubiquitylation of
Nascent Globin Chains in a Cell-free System." J. Biol. Chem.
279(40): 41767-41774.
Alroy I., et al. (2005) "The trans-Golgi network-associated
human ubiquitin-protein ligase POSH is essential for HIV type 1
production." PNAS 102(5): 1478-1483.
Baldin, V., et al. (2008) ‘A Novel Role for PA28-Proteasome in
Nuclear Speckle Organization and SR Protein Trafficking.’ Mol.
Biol. Cell 19: 1706-16.
Chen L. and Madura K. (2005) "Increased Proteasome Activity,
Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor
Detected in Breast Cancer Tissue." Cancer Res. 65(13):
5599-5606.
Chu, I., et al. (2007). "Src promotes estrogen-dependent
estrogen receptor {alpha} proteolysis in human breast cancer."
J. Clin. Invest. 117(8): 2205-2215.
Chuang S.-M., et al. (2005) "Proteasome-Mediated Degradation of
Cotranslationally Damaged Proteins Involves Translation
Elongation Factor 1A." Mol. Cell. Biol. 25(1): 403-413.
Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3)
Mediates Ubiquitination and Degradation of Tumor Necrosis Factor
Receptor II." Mol. Cell. Biol. 25(11): 4716-4726.
Demo, S. D., et al. (2007). "Antitumor Activity of PR-171, a
Novel Irreversible Inhibitor of the Proteasome." Cancer Res.
67(13): 6383-6391.
Depre, C., Q. Wang, et al. (2006). "Activation of the Cardiac
Proteasome During Pressure Overload Promotes Ventricular
Hypertrophy." Circulation 114(17): 1821-1828.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces
alterations of the ubiquitin-proteasome pathway in the
diaphragm." J. Appl .Physiol .98(4): 1314-1321.
Drews, O., R. Wildgruber, et al. (2007). "Mammalian proteasome
subpopulations with distinct molecular compositions and
proteolytic activities." Mol. Cell. Proteomics. 6(11):202102031
Dudek E. J., et al. (2005) "Selectivity of the ubiquitin pathway
for oxidatively modified proteins: relevance to protein
precipitation diseases." FASEB J (12): 1707-9
Fareed, M. U., et al. (2006). "Treatment of rats with calpain
inhibitors prevents sepsis-induced muscle proteolysis
independent of atrogin-1/MAFbx and MuRF1 expression." Am J
Physiol Reg. Integ. Comp. Physiol. 290(6): R1589-1597.
Ferdous, A., et al. (2007). "The role of the proteasomal ATPases
and activator mono-ubiquitylation in regulating Gal4 binding to
promoters." Genes & Dev. 21(1): 112-123.
Floyd, Z. E., et al. (2007). "Degradation of STAT5 proteins in
3T3-L1 adipocytes is induced by TNF-{alpha} and cycloheximide in
a manner independent of STAT5A activation." Am J Physiol
Endocrinol Metab 292(2): E461-4
Gallagher, M. J., et al. (2007). "The GABAA receptor 1 subunit
epilepsy mutation A322D inhibits transmembrane helix formation
and causes proteasomal degradation." PNAS 104(32): 12999-13004.
Ghaboosi, N. and R. J. Deshaies (2007). "A Conditional Yeast E1
Mutant Blocks the Ubiquitin-Proteasome Pathway and Reveals a
Role for Ubiquitin Conjugates in Targeting Rad23 to the
Proteasome." Mol. Biol. Cell 18(5): 1953-1963.
Guo W., et al. (2004) "Differential Regulation of Components of
the Ubiquitin-Proteasome Pathway during Lens Cell
Differentiation." Invest. Ophthalmol. Vis. Sci. 45(4):
1194-1201.
Hedhli, N., et al. (2008) ‘Proteasome activation during cardiac
hypertrophy by the chaperone H11 Kinase/Hsp22.’ Cardiovasc. Res.
77: 497-505.
Kavazis, A. N., et al. (2007). "Diaphragmatic proteasome
function is maintained in the aging Fisher 344 rat." Exp Physiol:
92(5):895-901.
Kisselev, A. F., et al. (2006). "Importance of the Different
Proteolytic Sites of the Proteasome and the Efficacy of
Inhibitors Varies with the Protein Substrate." J. Biol. Chem.
281(13): 8582-8590.
Liang M., et al. (2004) "Ubiquitination and Proteolysis of
Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol.
24(17): 7524-7537.
Marfella, R., et al. (2007). "Morning Blood Pressure Surge as a
Destabilizing Factor of Atherosclerotic Plaque: Role of
Ubiquitin-Proteasome Activity." Hypertension 49(4): 784-791.
Marfella, R., et al. (2008) ‘Proteasome Activity as a Target of
Hormone Replacement Therapy-Dependent Plaque Stabilization in
Postmenopausal Women.’ Hypertension 51: 1135-41.
Marteijn, J. A. F., et al. (2006). "Diminished proteasomal
degradation results in accumulation of Gfi1 protein levels in
monocytes." Blood: 109: 100-108
Mehle A., et al. (2004) "Vif Overcomes the Innate Antiviral
Activity of APOBEC3G by Promoting Its Degradation in the
Ubiquitin-Proteasome Pathway." J. Biol. Chem. 279(9): 7792-7798.
Reuter C. J. and Maupin-Furlow J.A. (2004) "Analysis of
Proteasome-Dependent Proteolysis in Haloferax volcanii Cells,
Using Short-Lived Green Fluorescent Proteins." Appl. Envir.
Microbiol. 70(12): 7530-7538.
Shang F., et al. (2005) "Lys6-modified Ubiquitin Inhibits
Ubiquitin-dependent Protein Degradation." J. Biol. Chem.
280(21): 20365-20374.
Smith, I. J. and S. L. Dodd (2007). "Muscle: Calpain activation
causes a proteasome-dependent increase in protein degradation
and inhibits the Akt signalling pathway in rat diaphragm
muscle." Exp Physiol 92(3): 561-573.
Suzuki N., et al. (2004) "Proteasomal Degradation of the Nuclear
Targeting Growth Factor Midkine." J. Biol. Chem. 279(17):
17785-17791.
Wei, W., et al. (2006). "Treatment of cultured myotubes with the
proteasome inhibitor {beta}-lactone increase expression of the
transcription factor C/EBP." Am J Physiol Cell Physiol:
292:C216-C226.
Wherry, E. J., et al. (2006). "Re-evaluating the Generation of a
"Proteasome-Independent" MHC Class I-Restricted CD8 T Cell
Epitope." J. Immunol. 176(4): 2249-2261.
Willeumier, K., et al. (2006). "Proteasome Inhibition Triggers
Activity-Dependent Increase in the Size of the Recycling Vesicle
Pool in Cultured Hippocampal Neurons." J. Neurosci. 26(44):
11333-11341.
Williamson, M. J., et al. (2006). "Comparison of biochemical and
biological effects of ML858 (salinosporamide A) and bortezomib."
Mol. Cancer Ther. 5(12): 3052-3061.
Yang, Q.-H. and Du C.(2004) "Smac/DIABLO Selectively Reduces the
Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in
HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Yang Z., et al. (2008) Kaposi's Sarcoma-Associated Herpesvirus
Transactivator RTA Promotes Degradation of the Repressors To
Regulate Viral Lytic Replication. J. Virol. 82: 3590-603
Yimlamai T., et al. (2005) "Clenbuterol induces muscle-specific
attenuation of atrophy through effects on the
ubiquitin-proteasome pathway." J Appl Physiol 99(1): 71-80.
^ Top
SUMO
Benson, M. D., et al. (2007). "SUMO
modification regulates inactivation of the voltage-gated
potassium channel Kv1.5." PNAS 104(6): 1805-1810.
Chou, C.-C., et al. (2007). "SUMO modification regulates the
DNA-binding activity of GCMa." J. Biol. Chem.: 282(37):
27239-27249.
Kagey M. H., et al. (2005) "Multiple activities contribute to
Pc2 E3 function." EMBO J. 24(1): 108-119.
Lois L. M. and Lima C. D. (2005) "Structures of the SUMO E1
provide mechanistic insights into SUMO activation and E2
recruitment to E1." EMBO J. 24(3): 439-451.
Muromoto, R., et al. (2006). "Sumoylation of Daxx Regulates
IFN-Induced Growth Suppression of B Lymphocytes and the Hormone
Receptor-Mediated Transactivation." J. Immunol. 177(2):
1160-1170.
van Waardenburg, R. C. A. M., et al. (2006). "Distinct
Functional Domains of Ubc9 Dictate Cell Survival and Resistance
to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969.
Yurchenko, V., et al. (2006). "SUMO Modification of Human XRCC4
Regulates Its Localization and Function in DNA Double-Strand
Break Repair." Mol. Cell. Biol. 26(5): 1786-1794.
^ Top
TRANSCRIPTION FACTORS
Bish, R. A. and M. P. Myers (2007). "Werner
Helicase-interacting Protein 1 Binds Poly-ubiquitin via Its Zinc
Finger Domain." J. Biol. Chem. 282(32): 23184-23193.
Frampton, J., et al. (2006) "Postreplication Repair and PCNA
Modification in Schizosaccharomyces pombe." Mol. Biol. Cell
17(7): 2976-2985.
Gurova K. V., et al. (2005) "Small molecules that reactivate p53
in renal cell carcinoma reveal a NF- B-dependent mechanism of
p53 suppression in tumors." PNAS 102(48): 17448-17453.
Gurtan, A. M., et al. (2006) "The WD40 Repeats of FANCL Are
Required for Fanconi Anemia Core Complex Assembly." J. Biol.
Chem. 281(16): 10896-10905.
Haracska, L., et al. (2006) "Ubiquitylation of yeast
proliferating cell nuclear antigen and its implications for
translesion DNA synthesis." PNAS 103(17): 6477-6482.
Havens, C. G., et al. (2006) "Regulation of Late G1/S Phase
Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell.
Biol. 26(12): 4701-4711.
Jung, Y. and S. J. Lippard (2006). "RNA Polymerase II Blockage
by Cisplatin-damaged DNA: Stability and poly-ubiquitylation of
stalled polymerase." J. Biol. Chem. 281(3): 1361-1370.
Jung Y. and Lippard S.J. (2005) "RNA polymerase II blockage by
cisplatin-damaged DNA:Stability and poly-ubiquitylation of
stalled polymerase." J. Biol. Chem.: 281-25001-25005.
Karagianni, P., et al. (2008) “ICBP90, a Novel Methyl K9 H3
Binding Protein Linking Protein Ubiquitination with
Heterochromatin Formation” Mol. Cell. Biol. 28: 705-17.
Kerns, S. L., et al. (2007). "Geminin Prevents Re-replication
during Xenopus Development." J. Biol. Chem. 282(8): 5514-5521.
Laine, A., I. et al. (2006). "Regulation of p53 Localization and
Activity by Ubc13." Mol. Cell. Biol. 26(23): 8901-8913.
Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the
Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol.
26(11): 4122-4133.
Lotz C., et al. (2005) "Targeting Positive Regulatory Domain
I-Binding Factor 1 and X Box-Binding Protein 1 Transcription
Factors by Multiple Myeloma-Reactive CTL." J. Immunol. 175(2):
1301-1309.
Miyase S., et al. (2005) "Differential Regulation of Rad18
through Rad6-dependent mono- and poly-ubiquitination." J. Biol.
Chem. 280(1): 515-524.
Prager, K., et al. (2007) "A Structural Switch of Presenilin 1
by Glycogen Synthase Kinase 3beta-mediated Phosphorylation
Regulates the Interaction with beta-Catenin and Its Nuclear
Signaling." J. Biol. Chem. 282(19): 14083-14093.
Ogawa S., et al. (2004) "A nuclear receptor corepressor
transcriptional checkpoint controlling activator protein
1-dependent gene networks required for macrophage activation."
PNAS 101(40): 14461-14466.
Wei, W., et al. (2007). "Treatment of cultured myotubes with the
proteasome inhibitor beta-lactone increases the expression of
the transcription factor C/EBPbeta." Am. J. Physiol. Cell
Physiol. 292(1): C216-226.
Watanabe K., et al. (2004) "Rad18 guides pol{eta} to replication
stalling sites through physical interaction and PCNA mono-ubiquitination."
EMBO J. 23(19): 3886-3896.
Yan C., et al. (2005) "Activating transcription factor 3, a
stress sensor, activates p53 by blocking its ubiquitination."
EMBO J. 24(13): 2425-2435.
Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex
with DDB1 and DET1 in vivo and enhances the activity of
ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181.
Yang J., et al. (2005) "Light Regulates COP1-Mediated
Degradation of HFR1, a Transcription Factor Essential for Light
Signaling in Arabidopsis." Plant Cell 17(3): 804-821.
Yuasa, M. S., et al. (2006). "A human DNA polymerase-complex
containing Rad18, Rad6 and Rev1; proteomic analysis and
targeting of the complex to the chromatin-bound fraction of
cells undergoing replication fork arrest." Genes Cells 11(7):
731-744.
Zhang D. D., et al. (2005) "Ubiquitination of Keap1, a BTB-Kelch
Substrate Adaptor Protein for Cul3, Targets Keap1 for
Degradation by a Proteasome-independent Pathway." J. Biol. Chem.
280(34): 30091-30099.
^ Top
UBIQUITIN CONJUGATING ENZYMES
* Bazirgan O.A and Hampton R.Y. 2008.
“Cue1p is an activator of Ubc7p E2 activity in vitro and in
vivo.” J. Biol. Chem.: M801122200
Chen L. and Madura K. (2005) "Increased Proteasome Activity,
Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor
Detected in Breast Cancer Tissue." Cancer Res. 65(13):
5599-5606.
Gazdoiu S., et al. (2005) "Proximity-induced activation of human
Cdc34 through heterologous dimerization." PNAS 102(42):
15053-15058.
Laine, A., et al. (2006) "Regulation of p53 Localization and
Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.
Liu, Q., et al. (2006). "Ubiquitin-Conjugating Enzyme 3 Delays
Human Lens Epithelial Cells in Metaphase." Invest. Ophth.. Vis.
Sci. 47(4): 1302-1309.
Oh K.-J., et al. (2004) "The Papillomavirus E7 Oncoprotein Is
Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3
Ligase." J. Virol. 78(10): 5338-5346.
Oh, R. S., et al. (2006) "Human Homologs of Ubc6p
Ubiquitin-conjugating Enzyme and Phosphorylation of HsUbc6e in
Response to Endoplasmic Reticulum Stress." J. Biol. Chem.
281(30): 21480-21490.
Plafker S. M., et al. (2004) "Ubiquitin charging of human class
III ubiquitin-conjugating enzymes triggers their nuclear
import." J. Cell Biol. 167(4): 649-659.
Petroski, M. D., et al. (2007). "Substrate modification with
lysine 63-linked ubiquitin chains through the UBC13-UEV1A
ubiquitin-conjugating enzyme." J. Biol. Chem. 282:29729-29737.
van Waardenburg, R. C. A. M., et al. (2006). "Distinct
Functional Domains of Ubc9 Dictate Cell Survival and Resistance
to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969.
Wen, R., et al. (2008) “Arabidopsis UEV1D Promotes
Lysine-63-Linked Poly-ubiquitination and is Involved in DNA
Damage Response.” Plant Cell 20: 213-27.
Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex
with DDB1 and DET1 in vivo and enhances the activity of
ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181.
^ Top
OTHERS
Ausseil, F., et al. (2007).
"High-Throughput Bioluminescence Screening of
Ubiquitin-Proteasome Pathway Inhibitors from Chemical and
Natural Sources." J. Biomol. Screen. 12(1): 106-116.
Guo, W., et al. (2006). "Ubiquitin-Proteasome Pathway Function
Is Required for Lens Cell Proliferation and Differentiation."
Invest. Ophth. Vis. Sci. 47(6): 2569-2575.
Lin, JH-C., et al. (2008) “A Central Role of Connexin 43 in
Hypoxic Preconditioning. J. Neurosci.” 28: 681-95.
Link, M. A., et al. (2007). "Cathepsin B Mediates Cleavage of
Herpes Simplex Virus Type 1 Origin Binding Protein (OBP) To
Yield OBPC-1, and Cleavage Is Dependent upon Viral DNA
Replication.”J. Virol. 81(17): 9175-9182
Marfella, R., et al. (2008) “Effects of Ubiquitin-Proteasome
System Deregulation on the Vascular Senescence and
Atherosclerosis Process in Elderly Patients.” J. Gerontol. A
Biol. Sci. Med. Sci. 63: 200-3.
*McClung, J.M., et al. (2008) Redox regulation of diaphragm
proteolysis during mechanical ventilation. Am J Physiol
Regulatory Integrative Comp Physiol: 00044.2008
Page, E.L., et al. (2008) “Hypoxia-inducible Factor-1
Stabilization in Non-hypoxic Conditions: Role of Oxidation and
Intracellular Ascorbate Depletion.” Mol. Biol. Cell 19: 86-94.
Sato K., et al. (2004) "Degradation of Fodrin by m-Calpain in
Fibroblasts Adhering to Fibrillar Collagen I Gel." J. Biochem.
(Tokyo) 136(6): 777-785.
Sparks, S. E., et al. (2005) "Use of a cell-free system to
determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine
kinase activities in human hereditary inclusion body myopathy."
Glycobiology 15(11): 1102-1110.
Yan, Z., et al. (2006). "Unique Biologic Properties of
Recombinant AAV1 Transduction in Polarized Human Airway
Epithelia." J. Biol. Chem. 281(40): 29684-29692.
Zollars, E. S., et al. (2006). "Simple electrostatic model
improves designed protein sequences." Protein Sci. 15(8):
2014-2018.
^ Top |
|
