Proteasome Degradation
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Alroy I., et al. (2005) "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production." PNAS 102(5): 1478-1483.
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Archer C.T., et al. (2008) "Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome." J. Biol. Chem. 283(31): 21789-21798.
Archer, C. and Kodadek, T. (2010) “The hydrophobic patch of ubiquitin is required to protect transactivator–promoter complexes from destabilization by the proteasomal ATPases.” Nucleic Acids Res. 38: 789 - 796.
Baldin, V., et al. (2008) ‘A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking.’ Mol. Biol. Cell 19: 1706-16.
Bauer, S., et al. (2010) “Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells.” Cancer Res. 70: 150 - 159.
Bianchi, G., et al. (2009) "The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition." Blood 113: 3040-3049.
Burnett, B.G., et al. (2009) "Regulation of SMN Protein Stability." Mol. Cell. Biol. 29: 1107-1115.
Burns, K.E., et al. (2009) "Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein." J. Biol. Chem. 284(5): 3069-3075.
Chandra, A., et al. (2010) “Proteasome Assembly Influences Interaction with Ubiquitinated Proteins and Shuttle Factors.” J. Biol. Chem. 285: 8330 - 8339.
Chen L. and Madura K. (2005) "Increased Proteasome Activity, Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor Detected in Breast Cancer Tissue." Cancer Res. 65(13): 5599-5606.
Chen, L., et al. (2011) “Sts1 Plays a Key Role in Targeting Proteasomes to the Nucleus.” The Journal of Biological Chemistry, 286: 3104-3118.
Chu, I., et al. (2007). "Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer." J. Clin. Invest. 117(8): 2205-2215.
Chuang S.-M., et al. (2005) "Proteasome-Mediated Degradation of Cotranslationally Damaged Proteins Involves Translation Elongation Factor 1A." Mol. Cell. Biol. 25(1): 403-413.
Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3) Mediates Ubiquitination and Degradation of Tumor Necrosis Factor Receptor II." Mol. Cell. Biol. 25(11): 4716-4726.
Dasmahapatra, G., et al. (2010) "The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo." Blood. 115: 4478 - 4487.
Demo, S. D., et al. (2007). "Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome." Cancer Res. 67(13): 6383-6391.
Depre, C., Q. Wang, et al. (2006). "Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy." Circulation 114(17): 1821-1828.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl .Physiol .98(4): 1314-1321.
Dominy, J.E., et al. (2006). "Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat." Biochem. J. 394: 267-273.
Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Fruh K, Moses AV. (2009) "Vpu Directs the Degradation of the HIV Restriction Factor BST-2/tetherin via a bTrCP-dependent Mechanism." J. Virol.: JVI.00242-09.*
Drews, O., et al. (2007). "Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities." Mol. Cell. Proteomics. 6(11):2021-2031
Dudek E. J., et al. (2005) "Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases." FASEB J (12): 1707-9
Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am J Physiol Reg. Integ. Comp. Physiol. 290(6): R1589-1597.
Ferdous, A., et al. (2007). "The role of the proteasomal ATPases and activator mono-ubiquitylation in regulating Gal4 binding to promoters." Genes & Dev. 21(1): 112-123.
Fernandes, A., et al. (2009) “Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells.” Mol. Biol. Cell 20: 3690 -
Fernandez, A.F., et al. (2008) " Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8." J. Biol. Chem. 283(30): 20745-20753.
Fernandez, A.F., et al. (2008) " Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8." J. Biol. Chem. 283(30): 20745-20753.
Floyd, Z. E., et al. (2007). "Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-α and cycloheximide in a manner independent of STAT5A activation." Am J Physiol Endocrinol Metab 292(2): E461-4
Gallagher, M. J., et al. (2007). "The GABAA receptor α1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation." PNAS 104(32): 12999-13004.
Garza, R.M., et al. (2009) "In Vitro Analysis of Hrd1p-mediated Retrotranslocation of its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase." J. Biol. Chem. 284: 14710-14722.
Ghaboosi, N. and R. J. Deshaies (2007). "A Conditional Yeast E1 Mutant Blocks the Ubiquitin-Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome." Mol. Biol. Cell 18(5): 1953-1963.
Gho, A.M., et al. (2008). "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins." BMC Biochem. 9:4.
Guo W., et al. (2004) "Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation." Invest. Ophthalmol. Vis. Sci. 45(4): 1194-1201.
Hedhli, N., et al. (2008) ‘Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.’ Cardiovasc. Res. 77: 497-505.
Heuzé, M.L., et al. (2008) "ASB2 targets filamins A and B to proteasomal degradation." Blood 112(13): 5130-5140.
Ikeda, Y., et al. (2009) “Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein: p97 Recruits Proteasomes to Insig-1 Before Extraction From Membranes.” J. Biol. Chem. 284: 34889 - 34900.
Kavazis, A. N., et al. (2007). "Diaphragmatic proteasome function is maintained in the aging Fisher 344 rat." Exp Physiol: 92(5):895-901.
Kim, H.T.., et al. (2009) "S5a promotes protein degradation by blocking synthesis of non-degradable forked ubiquitin chains." EMBO J. 28: 1867-1877.
Kisselev, A. F., et al. (2006). "Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate." J. Biol. Chem. 281(13): 8582-8590.
Koodathingal, P., et al. (2009) "ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins." J. Biol. Chem. 284: 18674-18684.
Koodathingal, P., et al. (2009) “ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins.” J. Biol. Chem. 284: 18674 - 18684.
Korzeniewski, N., et al. (2010) “Daughter Centriole Elongation Is Controlled by Proteolysis.” Mol. Biol. Cell 21: 3942-3951.
Kumar, B., et al. (2010) “The C Terminus of Rpt3, an ATPase Subunit of PA700 (19 S) Regulatory Complex, Is Essential for 26 S Proteasome Assembly but Not for Activation.” J. Biol. Chem. 285: 39523-39535.
Lee, C.-M., et al. (2010) “Metabolism and Action of Proteasome Inhibitors in Primary Human Hepatocytes.” Drug Metab. Dispos. 38: 2166-2172.
Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537.
Lin, G., et al. (2008) "Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates." J. Biol. Chem. 283(49): 34423-34431.
Lin, Y., et al. (2011) “The Defective Proteasome but Not Substrate Recognition Function Is Responsible for the Null Phenotypes of the Arabidopsis Proteasome Subunit RPN10.” PLANT CELL 23: 2754 - 2773.
Liu, J., et al. (2008) "A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome." Am. J. Physiol. Heart.Circ. Physiol. 295(6): H2541-H2550.
Marfella, R., et al. (2007). "Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin-Proteasome Activity." Hypertension 49(4): 784-791.
Marfella, R., et al. (2008) ‘Proteasome Activity as a Target of Hormone Replacement Therapy-Dependent Plaque Stabilization in Postmenopausal Women.’ Hypertension 51: 1135-41.
Marteijn, J. A. F., et al. (2006). "Diminished proteasomal degradation results in accumulation of Gfi1 protein levels in monocytes." Blood: 109: 100-108
McClung J.M., et al. (2008). "Redox regulation of diaphragm proteolysis during mechanical ventilation." Am. J. Physiol. Regul. Integ. Comp. Physiol. 294: R1608-1617.
Mehle A., et al. (2004) "Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway." J. Biol. Chem. 279(9): 7792-7798.
Mi, L., et al. (2011) “Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.” Carginogenesis, 32: 216-223.
Middeldorp J., et al. (2009) "Intermediate filament transcription in astrocytes is repressed by proteasome inhibition." FASEB J: fj.08-127696.*
Nagel, C., et al. (2011) “Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation.” J. Virol. 85: 7644 - 7657.
Obaidat, A., et al. (2011) “Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.” Jour. of Pharm. and Exp. Therapeutics: doi:10.1124/jpet.110.177824
Okamura, T., et al. (2003) "Abnormally high expression of proteasome activator-γ in thyroid neoplasm." Clin. Endocrin. Metab. 88(3): 31374031383.
Owens, L, et al. (2010) “Activation Domain-dependent Degradation of Somatic Wee1 Kinase.” J. Biol. Chem. 285: 6761 - 6769.
Parlati, F., et al. (2009) “Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.” Blood 114: 3439 - 3447.
Phan, V.T., et al. (2010) “The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans.” Mol. Cell. Biol. 30: 2264 - 2279.
Reis, J., et al. (2008) "A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model." Innate Immunity 14(5): 319-329.
Reuter C. J. and Maupin-Furlow J.A. (2004) "Analysis of Proteasome-Dependent Proteolysis in Haloferax volcanii Cells, Using Short-Lived Green Fluorescent Proteins." Appl. Envir. Microbiol. 70(12): 7530-7538.
Rinetti, G.V. and Schweizer, F. (2010) “Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons.” J. Neurosci. 30: 3157 - 3166.
Rousseau, E., et al. (2009) "Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones." J. Biol. Chem. 284(3): 1917-1929.
Screen, M., et al. (2010) “Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors.” J. Biol. Chem. 285: 40125-40134.
Shang F., et al. (2005) "Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation." J. Biol. Chem. 280(21): 20365-20374.
Shen, H-W., et al. (2009) "Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats." J. Neurosci. 29: 28762884.
Smith, I. J. and S. L. Dodd (2007). "Muscle: Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle." Exp Physiol 92(3): 561-573.
Solis, M., et al. (2010) “RIG-I Mediated Antiviral Signalling is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I” J. Virol. 10.1128/JVI.01635-10.*
Suzuki N., et al. (2004) "Proteasomal Degradation of the Nuclear Targeting Growth Factor Midkine." J. Biol. Chem. 279(17): 17785-17791.
Tanioka, T., et al. (2011) “Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells: INVOLVEMENT OF GLYCOGEN SYNTHASE KINASE-3β.” J
Uchida, S., et al. (2011) “SCFβTrCP mediates stress-activated MAPK-induced Cdc25B degradation.” J. Cell Sci. 124: 2816 - 2825.
Wang A.M., et al. (2010) "Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation." J. Biol. Chem. 285: 15714 - 15723.
Wang A.M., et al. (2010) "Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation." J. Biol. Chem. 285: 15714 - 15723.
Wang A.M., et al. (2010) "Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation." J. Biol. Chem. 285: 15714 - 15723.
Wang, X., et al (2010) “Regulation of the 26S Proteasome Complex During Oxidative Stress.” Sci. Signal. 3: ra88.*
Wang, Y., et al. (2011) “The ubiquitin-dependent proteasomal degradation (UPD) of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and Ubiquitination.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M110.176685
Wang, Z.Q., et al. (2009) "Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys." Diabetes 58: 1488-1498.
Wei, W., et al. (2006). "Treatment of cultured myotubes with the proteasome inhibitor β-lactone increase expression of the transcription factor C/EBPβ." Am J Physiol Cell Physiol: 292:C216-C226.
Wherry, E. J., et al. (2006). "Re-evaluating the Generation of a "Proteasome-Independent" MHC Class I-Restricted CD8 T Cell Epitope." J. Immunol. 176(4): 2249-2261.
Willeumier, K., et al. (2006). "Proteasome Inhibition Triggers Activity-Dependent Increase in the Size of the Recycling Vesicle Pool in Cultured Hippocampal Neurons." J. Neurosci. 26(44): 11333-11341.
Williamson, M. J., et al. (2006). "Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib." Mol. Cancer Ther. 5(12): 3052-3061.
Yamano T., et al. (2008) "α-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation: UNDERSTANDING THE CYTOTOXICITY OF PROTEIN PROTOFIBRILS IN NEURODEGENERATIVE DISEASE PATHOGENESIS." J. Biol. Chem. 283(29): 20288-20298.
Yamano T., et al. (2008) "α-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation: UNDERSTANDING THE CYTOTOXICITY OF PROTEIN PROTOFIBRILS IN NEURODEGENERATIVE DISEASE PATHOGENESIS." J. Biol. Chem. 283(29): 20288-20298.
Yang Z., et al. (2008) Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication. J. Virol. 82: 3590-603
Yang, Q.-H. and Du C.(2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Yimlamai T., et al. (2005) "Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway." J Appl Physiol 99(1): 71-80.
Zhang, N., et al. (2011) “Ubiquitin Chain Trimming Recycles the Substrate Binding Sites of the 26 S Proteasome and Promotes Degradation of Lysine 48-linked Polyubiquitin Conjugates.” J. Biol. Chem. 286: 25540 - 25546.
Zmijewski, J., et al. (2009) “S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function.” J. Biol. Chem. 284: 22213 - 22221.
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