E3 Ligases
*Nakao, R., et al. (2009) "Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading." Mol. Cell. Biol.: MCB.01347-08.
Abramovitch, R. B., et al. (2006). "Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity." PNAS 103(8): 2851-2856.
An, J.Y., et al. (2010) “UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.” PNAS 107: 1912 - 1917.
Arimoto, K.-I., et al. (2010) “Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.” PNAS 107: 15856-15861.
Balastik, M., et al. (2008) "Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration." PNAS 105 (33): 12016-12021.
Barajas, D., et al. (2009) “The Nedd4-Type Rsp5p Ubiquitin Ligase Inhibits Tombusvirus Replication by Regulating Degradation of the p92 Replication Protein and Decreasing the Activity of the Tombusvirus Replicase.” J. Virol. 83: 11751 - 11764
Bartee E., et al. (2004) "Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins." J. Virol. 78(3): 1109-1120.
Bernal-Bayard, J. and Ramos-Morales, F. (2009) “Salmonella Type III Secretion Effector SlrP Is an E3 Ubiquitin Ligase for Mammalian Thioredoxin.” J. Biol. Chem. 284: 27587 - 27595.
Bottomley M., et al. (2005) "NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1): Insights into Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Apeced) Disease." J. Biol. Chem. 280(12): 11505-11512.
Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear RING Domain Protein with Functional Connections to Chromatin Modification in Saccharomyces cerevisiae." Mol. Cell. Biol. 27(8): 2800-2811
Brooks, W.S., et al. (2008) "G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development." J. Biol. Chem. 283(32): 22304-22315.
Bunce, M.W., et al. (2008) "Coordinated Activation of the Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of Phosphatidylinositol 5-Phosphate." J. Biol. Chem. 283: 8678-8686.
Burnett, B. G. and Pittman R.N. (2005) "The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation." PNAS 102(12): 4330-4335.
Burns, M., et al. (2009) "Parkin promotes intracellular Aβ1–42 clearance." Hum. Mol. Genet. 18: 3206 - 3216.
Butler, M. P., et al. (2007). "Kinase active IRAKs promote polyubiquitination and degradation of the Pellino family: Direct evidence for Pellino proteins being E3 ubiquitin ligases." J. Biol. Chem. 282:29729-29737.
Canning, M., et al. (2004) "A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7." J. Biol. Chem. 279(37): 38160-38168.
Cao, X., et al. (2011) “WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27 Kip1 Degradation in Human Diploid Fibroblasts.” J. Biol. Chem. 286: 33447 - 33456.
Chen, A., et al. (2009) “The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination.” Mol. Cell. Biol. 29: 5348 - 5356.
Chen, B.B., et al (2011) “Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis.” Molecular and Cellular Biology: doi:10.1128/MCB.00723-10.”
Cheng, P., et al. (2011) “Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development.” Neuron, 69: 231-243.
Choi, D.W., et al. (2008) "Ubiquitination and Degradation of Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box Protein WSB-1." J. Biol. Chem. 283: 4682-4689.
Choi, Y. et al. (2010) "The Human Cdc34 Carboxyl Terminus Contains a Non-covalent Ubiquitin Binding Activity That Contributes to SCF-dependent Ubiquitination." J. Biol. Chem. 285: 17754 - 17762.
Clapp, K. M., et al. (2010) “C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination.” J. Biol. Chem. 285: 33642-33651.
Cohen, S., et al. (2009) "During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation." J. Cell Biol. 185: 1083-1095
Cooper E. M., et al. (2004) "Biochemical Analysis of Angelman Syndrome-associated Mutations in the E3 Ubiquitin Ligase E6-associated Protein." J. Biol. Chem. 279(39): 41208-41217.
Cooper, E.M., et al. (2009) "K63-specific deubuiquitination by two JAMM/MPN+ complexes:BRISC-associated Brcc-36 and proteasomal Poh1." EMBO J. 28(6) 621-631
Corcoran, C., et al. (2009) “Identification and Characterization of Two Novel Isoforms of Pirh2 Ubiquitin Ligase That Negatively Regulate p53 Independent of RING Finger Domains.” J. Biol. Chem. 284: 21955 – 21970
Cotto-Rios, X.M., et al. (2011) “APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.” J. Cell Biol. 194: 177 - 186.
Dasgupta A., et al. (2004) "Sir Antagonist 1 (San1) Is a Ubiquitin Ligase." J. Biol. Chem. 279(26): 26830-26838.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl. Physiol. 98(4): 1314-1321.
Doss-Pepe E. W., et al. (2005) "α-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains." J. Biol. Chem. 280(17): 16619-16624.
Dul, B. E. and N. C. Walworth (2007). "The Plant Homeodomain Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase Activity." J. Biol. Chem. 282(25): 18397-18406.
Ensminger, A. and Isberg, R. (2010) “E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.” Infect. Immun., 78: 3905 - 3919.
Ensminger, A. W. and Isberg, R. R. (2010) “E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates.” Infect. Immun. 78: 3905-3919.
Enzler, T., et al. (2009) “MEKK1 Binds HECT E3 Ligase Itch by Its Amino-Terminal RING Motif to Regulate Th2 Cytokine Gene Expression.” J. Immunol. 183: 3831 - 3838.
Espinosa, A., et al. (2006). "The Sjogren's Syndrome-Associated Auto-antigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death." J. Immunol. 176(10): 6277-6285.
Everett, R.D., et al. (2010) "Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins." J. Virol. 84: 3476 - 3487.
Everett, R.D., et al. (2010). "Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins."J. Virol. 84: 3476 - 3487.
Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am. J. Physiol.Reg.Integ. Comp. Physiol. 290(6): R1589-1597.
Feltham, R., et al. (2011) “SMAC-mimetics activate the E3 ligase activity of cIAP1 by promoting RING dimerisation.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M111.222919.
Fielitz, J., et al. (2007). "Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3." J. Clin. Inv. 117(9): 2486-2495.
Fortier, J. M. and J. Kornbluth (2006). "NK Lytic-Associated Molecule, Involved in NK Cytotoxic Function, Is an E3 Ligase." J. Immunol. 176(11): 6454-6463.
Fortier, J. M. and J. Kornbluth (2006). "NK Lytic-Associated Molecule, Involved in NK Cytotoxic Function, Is an E3 Ligase." J. Immunol. 176(11): 6454-6463.
Fotia, A.B., et al. (2005). "The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities." Intl. J. Biochem. Cell. Biol. 38(3): 472-479.
Fouladkou, F., et al. (2010) “The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-.” J. Biol. Chem. 285: 6770 - 6780.
Fu, W., et al. (2009) "MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation." J. Biol. Chem. 284: 13987-14000.
Geng, L., et al. (2010) “RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.” J. Cell Biol. 191: 249-257.
Gentry M. S., et al. (2005) "From The Cover: Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin." PNAS 102(24): 8501-8506.
Goto, E., et al. (2003). "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." J. Biol. Chem. 278(17): 14657-14668.
Goto, E., et al. (2003). "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." J. Biol. Chem. 278(17): 14657-14668.
Habelhah H., et al. (2004) "Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB." EMBO J. 23(2): 322-332.
Hadian, K., et al. (2011) “NF-B Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-B Activation.” J. Biol. Chem. 286: 26107 - 26117.
Hallows, K.R., et al. (2010) “Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na+ Channel.” J. Biol. Chem. 285: 21671 - 21678.
Hattori, T., et al. (2007) "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27kip1." Can. Res. 67: 10789-10795.
He, F., B. J. Fenner, et al. (2006). "White Spot Syndrome Virus Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates Degradation of a Host Tumor Suppressor via Ubiquitination." J. Virol. 80(8): 3884-3892.
Herman, A., et al. (2011) “Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay.” Cancer Discovery 1: 312 - 325.
Hodson, C., et al. (2011) “Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway.” J. Biol. Chem. 286: 32628 - 32637.
Hrecka, K., M. Gierszewska, et al. (2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle." PNAS 104(28): 11778-11783.
Hrecka, K., M. Gierszewska, et al. (2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle." PNAS 104(28): 11778-11783.
Hsia, M. M. and Callis, J. (2010) “BRIZ1 and BRIZ2 Proteins Form a Heteromeric E3 Ligase Complex Required for Seed Germination and Post-germination Growth in Arabidopsis thaliana.” J. Biol. Chem. 285: 37070-37081
Hu S. and Yang X. (2003). "Cellular inhibitor of apoptosis1 and 2 are ubiquitin ligase for the apoptosis inducer Smac/DIABLO." J. Biol. Chem. 278(12): 10055-10060.
Hyuk Lee, D., et al. (2011) “The Pepper E3 Ubiquitin Ligase RING1 Gene, CaRING1, Is Required for Cell Death and the Salicylic Acid-Dependent Defense Response.” Plant Physiology 156: 2011 - 2025.
Jang I.-C., et al. (2005) "HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling." Genes & Dev. 19(5): 593-602.
Jin, X, et al. (2010) “An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-B-inducing Kinase via Lys63-linked Ubiquitination.” J. Biol. Chem. 285: 30539-30547.
Jo, Y., et al. (2011) “Membrane-associated Ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M110.211326.”
Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels." Mol. Biol. Cell 18(8): 3105-3118.
Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels." Mol. Biol. Cell 18(8): 3105-3118.
Jones, J., et al. (2011) “The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.” Immunology Letters, 2: 156-162.
Kalia, L.V., et al. (2011) “Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5).” PloS one, 6: e14695. doi:10.1371/journal.pone.0014695
Kawahara, K., et al. (2008) α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution: ROLE " IN THE PATHOGENESIS OF PARKINSON DISEASE." J. Biol. Chem. 283: 6979-6987.
Kee Y., et al. (2005) "The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme." EMBO J. 24(13): 2414-2424.
Kigoshi, Y., et al. (2011) “Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation.” J. Biol. Chem. 286: 33613 - 33621.
Kim, D. (2010) “The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA.” Mol. Cell. Biol. 30: 4120 - 4133.
Kim, D. H., et al. (2010) “The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA.” Mol. Cell. Biol. 30: 4120-4133.
Kim, H.C. and J.M. Huibregtse (2009) "Poly-ubiquitination by HECT E3s and the Determinants of Chain Type Specificity." Mol. Cell. Biol. 29: 3307-3318.
Kim, J., et al (2011) “Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus.” J. Virol. 85: 8116 - 8132.
Koh, M.Y., et al. (2008) "Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1, Leading to Its Oxygen-Independent Degradation." Mol. Cell. Biol. 28 (23):7081-7095.
Koike, A, et al. (2010) “Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates.” Cancer Res. 70: 6746 - 6756.
Koike, A., et al. (2010) “Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates.” Cancer Res. 70: 6746-6756.
Kong, H. J., et al. (2007). "Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages." J. Immunol. 179(1): 26-30.
Koutelou, E., et al. (2008) "Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1." J. Biol. Chem. 283: 3846-53.
Kraft E., et al. (2005) "Genome Analysis and Functional Characterization of the E2 and RING-Type E3 Ligase Ubiquitination Enzymes of Arabidopsis." Plant Physiology 139(4): 1597-1611.
Kus B., et al. (2005) "A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5." J. Biol. Chem. 280(33): 29470-29478.
Laine, A., I., et al. (2006). "Regulation of p53 Localization and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.
Lamothe, B., et al. (2007). "Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation." J. Biol. Chem. 282(6):Determinant of I 4102-4112.
Li, X.S., et al. (2010) "Mammalian SWI/SNF-A Subunit BAF250/ARID1 Is an E3 Ubiquitin Ligase That Targets Histone H2B." Mol. Cell. Biol. 30: 1673 - 1688.
Lilley B. N. and Ploegh H.L (2005) "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." PNAS 102(40): 14296-14301.
Lin, D., et al. (2011) “Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase from Escherichia coli O157:H7.” The Journal of Biological Chemistry, 286: 441-449.
Liu, L-J., et al. (2008) "COP1-Mediated Ubiquitination of CONSTANS Is Implicated in Cryptochrome Regulation of Flowering in Arabidopsis." Plant Cell. 20: 292-306.
Liu, Z., et al. (2009) "Human BRE1 Is an E3 Ubiquitin Ligase for Ebp1 Tumor Suppressor." Mol. Biol. Cell 20 (3): 757-768.
Lo, S.-C. and M. Hannink (2006). "PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex." J. Biol. Chem.: 281:37893-37903.
Lu, J., et al. (2011) “RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation.” J. Biol. Chem. 286: 24426 - 24433.
Lu, K., et al. (2011) “Pivotal role of the SMURF1 C2 domain in substrate selection.” The Journal of Biological Chemistry: doi:10.1074/jbc.M110.211979.
Lu, Z., et al. (2007). "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction." J. Cell Biol. 177(6): 1077-1081
Lui, Q.Y., et al. (2008). "A novel brain-enriched E3 ubiquitin ligase RNF182 is up-regulated in the brains of Alzheimer’s patients and targets ATP6VOC for degradation." Molec. Degen. 3:4.
Luke-Glaser S., et al. (2007). "CIF-1, a Shared Subunit of the COP9/Signalosome and Eukaryotic Initiation Factor 3 Complexes, Regulates MEL-26 Levels in theCaenorhabditis elegans Embryo." Mol. Cell. Biol. 27(12): 4526-4540.
Luo, H., et al. (2010) “The Arabidopsis Botrytis Susceptible1 Interactor Defines a Subclass of RING E3 Ligases That Regulate Pathogen and Stress Responses.” Plant Physiology 154: 1766-1782.
Maguire M., et al. (2008) "MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination." Canc. Res. 68: 3232-3242.
Malakhova O.A. and Zhang D-E. (2008) "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response." J. Biol. Chem. 283: 8783-8787.
Mansouri, M., et al. (2006). "Kaposi sarcoma herpes virus K5 removes CD31/PECAM from endothelial cells." Blood 108(6): 1932-1940.
Mao, X,. et al. (2009) "GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kB/RelA." Genes & Dev. 23: 849-861.
Mao, X., et al. (2011) “COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding.” J. Biol. Chem. 286: 32355 - 32365.
Marblestone, J. G., et al. (2010) “Novel Approach for Characterizing Ubiquitin E3 Ligase Function.” J. Biomol. Screen. 15: 1220-1228.
Marteijn J. A. F., et al. (2005) "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." Blood 106(13): 4114-4123.
Meisenberg, C., et al. (2011) “Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.” Nucleic Acids Res. 10.1093/nar/gkr744.
Miao, H., et al. (2010) "Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2."Acta Biochim Biophys Sin. 42: 303 - 310.
Miller, S. L. H., et al. (2007). "Ubiquitin-interacting Motifs Inhibit Aggregation of PolyQ-expanded Huntingtin." J. Biol. Chem. 282(13): 10096-10103.
Misaghi, S., et al. (2009) "Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1." Mol. Cell. Biol. 29: 2181-2192.
Miyauchi, Y., et al. (2008) "The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination." J. Biol. Chem. 283 (24):16622-16631.
Mo, P., et al. (2010) “MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3.” J. Biol. Chem. 285: 26908 - 26915.
Morokuma, Y., et al. (2007). "MARCH-XI, a Novel Transmembrane Ubiquitin Ligase Implicated in Ubiquitin-dependent Protein Sorting in Developing Spermatids." J. Biol. Chem. 282(34): 24806-24815.
Mudgil Y., et al. (2004) "A Large Complement of the Predicted Arabidopsis ARM Repeat Proteins Are Members of the U-Box E3 Ubiquitin Ligase Family." Plant Physiology 134(1): 59-66.
Mulder, K. W., A. Inagaki, et al. (2007). "Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae." Genetics 176(1): 181-192.
Nagel, C., et al. (2011) “Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation.” J. Virol. 85: 7644 - 7657.
Nelson, R. F., et al. (2006). "A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control." J. Biol. Chem. 281(29): 20242-20251.
Nerenberg B. T. H., et al. (2005) "The Poxviral RING Protein p28 Is a Ubiquitin Ligase That Targets Ubiquitin to Viral Replication Factories." J. Virol. 79(1): 597-601.
Nie, J., et al. (2010) “Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2.” J. Biol. Chem. 285: 22818 - 22830.
Nishikawa H., et al. (2004) "Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase." J. Biol. Chem. 279(6): 3916-3924.
Nishikawa, H., et al. (2009) "BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity." Canc. Res. 69 (1):111-119.
Oberfeld, B., et al. (2011) “Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.” Am J Physiol Renal Physiol. 301: F189 - F196.
Ogawa, M., et al. (2008) "Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase." Genes Cells 13: 397-409.
Ohtsubo M., et al. (2008) "Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity." PNAS 105(30): 10396-10401.
Olzmann, J.A., et al. (2007) "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6." J. Cell Biol. 178(6): 1025-1038.
Pan Y. and Chen J. et al. (2003). "MDM2 promotes ubiquitination and degradation of MDMX." Mol. Cell. Biol. 23(15): 5113-5121.
Peng H.-M., et al. (2004) "Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase." J. Biol. Chem. 279(51): 52970-52977.
Pierre S., et al. (2008) "Toponomics analysis of functional interactions of the ubiquitin ligase PAM during spinal nociceptive processing." Mol. Cell. Proteomics. 7(12)2475-2485
Priest, C., et al. (2010) “Deconstructing nucleotide binding activity of the Mdm2 RING domain.” Nucleic Acids Res. 10.1093/nar/gkq669.
Priest, C., et al. (2010) “Deconstructing nucleotide binding activity of the Mdm2 RING domain.” Nucleic Acids Res. 38: 7587-7598.
Quezada, C.M., et al. (2009) "A family of Salmonella virulence factors functions as a distinct class of auto-regulated E3 ubiquitin ligases." PNAS 106 (12): 4864-4869.
Rajendra R., et al. (2004) "Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53." J. Biol. Chem. 279(35): 36440-36444.
Rakovic, A., et al. (2011) “Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts.” PLoS one, 6: e16746. doi:10.1371/journal.pone.0016746.
Ramamoorthy, S., et al. (2010) “Isoform-Specific Degradation of PR-B by E6-AP Is Critical for Normal Mammary Gland Development.” Mol. Endocrinol. 24: 2099-2113.
Ramamoorthy, S., et al. (2010) “Isoform-Specific Degradation of PR-B by E6-AP Is Critical for Normal Mammary Gland Development.” Mol. Endocrinol., 10.1210/me. 2010-0116.
Ryan, P.E., et al. (2010) “The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme.” J. Biol. Chem. 285: 23687 - 23698.
Sangadala, S., et al. (2006). "LIM Mineralization Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness via a Novel Interaction with Smurf1 Resulting in Decreased Ubiquitination of Smads." J. Biol. Chem. 281(25): 17212-17219.
Sargin, B., C. Choudhary, et al. (2007). "Flt3-dependent transformation by inactivating c-Cbl mutations in AML." Blood 110(3): 1004-1012.
Sasaki, M., et al. (2007). "MDM2 Binding Induces a Conformational Change in p53 That Is Opposed by Heat-shock Protein 90 and Precedes p53 Proteasomal Degradation." J. Biol. Chem. 282(19): 14626-14634.
Scortegagna, M., et al. (2011) “USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains.” J. Biol. Chem. 286: 27333 - 27341.
Secombe J. and Parkhurst S.M. (2004) "Drosophila Topors Is a RING Finger-containing Protein That Functions as a Ubiquitin-protein Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor Protein." J. Biol. Chem. 279(17): 17126-17133.
Sehat B, et al. (2008). "Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis" Canc. Res. 68: 5669-5677.
Sekine K., et al. (2008). "Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation." J. Biol. Chem. 283(14): 8961-8968.
Shao, G., et al. (2009) "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks." Genes & Dev. 23: 740-754.
Shi, C. and Kehrl, J.H. (2010) “TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy.” Sci. Signal. 3: ra42.
Shibata, E., et al. (2011) “Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex.” Mol. Cell. Biol. 31: 3136 - 3145.
Shin, J., et al. (2011) “PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease.” Cell, 144: 689-702.
Simonin, A. and Fuster, D. (2010) “Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and Function.” J. Biol. Chem. 285: 38293-38303.
Song, I. Y., et al. (2010) “Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway.” J. Biol. Chem. 285: 31525-31536.
Sorkhy, M.A., et al. (2009) "The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4." J. Biol. Chem. 284(5): 2617-2627.
Starita L. M., et al. (2004) "BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number." Mol. Cell. Biol. 24(19): 8457-8466.
Stone S. L., et al. (2005) "Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis." Plant Physiology 137(1): 13-30.
Sung, C.K., et al. (2011) “Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150Sal2.” The FASEB Journal fj.10-173674; published ahead of print January 12, 2011,doi:10.1096/fj.10-173674.
Takedachi, A., et al. (2010) "DDB2 Complex-Mediated Ubiquitylation around DNA Damage Is Oppositely Regulated by XPC and Ku and Contributes to the Recruitment of XPA" Mol. Cell. Biol. 30: 2708 - 2723.
Tatematsu, K., et al. (2008) "Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase Cβ." J. Biol. Chem. 283: 11575-85.
Torres, M.P., et al. (2009) "G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase." J. Biol. Chem. 284 (13): 8940-8950.
Tsz-Mei Lok, G., et al. (2011) “Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.” Nucleic Acids Res. 10.1093/nar/gkr655.
Tursun B., et al. (2005) "The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones." Genes & Dev. 19(19): 2307-2319.
Uchiki T., et al. (2009) "The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition." J. Biol. Chem. 284: 12622-12632.
Umebayashi K., et al. (2008) " Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation." Mol. Biol. Cell. 19(8): 3454-3462.
Varfolomeev E., et al. (2008) "c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α(TNFα)-induced NF-κB Activation." J. Biol. Chem. 283(36): 24295-24299.
Vega-Sanchez M.E., et al. (2008) "SPIN1, a K Homology Domain Protein Negatively Regulated and E3 Ubiquitin Ligase SPL11, Is Involved in Flowering Time Control in Rice." Plant Cell 20: 1456-1469.
Vichi A., et al. (2005) "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)" PNAS 102(6): 1945-1950.
Wada K. And Kamitani T. (2006) "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself." Biochem. Biophys. Res. Comm. 342(1): 253-258.
Walters, M.S., et al. (2010) “The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies.” J. Virol. 84: 6861 - 6865.
Wang A.M., et al. (2010) "Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation." J. Biol. Chem. 285: 15714 - 15723.
Wang Z., et al. (2005) "RING-H2 Protein WSSV249 from White Spot Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme, PvUbc, for Viral Pathogenesis." J. Virol. 79(14): 8764-8772.
Wang, B., et al. (2009) "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control." Genes & Dev. 23: 729-739.
Wang, H., et al. "Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6." J. Biol. Chem. 285: 13201 - 13210.
Wang, X., et al. (2006). "The Viral E3 Ubiquitin Ligase mK3 Uses the Derlin/p97 Endoplasmic Reticulum-associated Degradation Pathway to Mediate Down-regulation of Major Histocompatibility Complex Class I Proteins." J. Biol. Chem. 281(13): 8636-8644.
Wang, X., et al. (2007). "Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3." J. Cell Biol. 177(4): 613-624.
Wang, X., et al. (2011). “MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination.” J. Biol. Chem. 286: 23725 - 23734.
Wawrzynow, B., et al. (2009) "A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity." J. Biol. Chem. 284: 11517-11530.
Worby, C.A., et al. (2008) "Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG)". J. Biol. Chem. 283: 4069-76.
Wu, W., H. Nishikawa, et al. (2007). "BRCA1 Ubiquitinates RPB8 in Response to DNA Damage." Cancer Res. 67(3): 951-958.
Yamada, M., J. Ohnishi, et al. (2006). "NARF, an emo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)." J. Biol. Chem. 281(30): 20749-20760.
Yamauchi, K., et al. (2008). "Ubiquitination of E3 ligase TRIM5α and its potential role." FEBS J. 275(7): 1540-1555.
Yang, M., et al. (2011) “E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC.” J. Exp. Med. 208: 2099 - 2112.
Yang, Y., et al. (2010) “E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF-induced JNK activation.” PNAS 107: 13444 - 13449.
Yao D., et al. (2004) "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." PNAS 101(29): 10810-10814.
Yogosawa S., et al.. (2005) "Ubiquitylation and Degradation of Serum-inducible Kinase by hVPS18, a RING-H2 Type Ubiquitin Ligase." J. Biol. Chem. 280(50): 41619-41627.
Yurchenko, V., et al. (2003). "The RAG1 N-terminal domain is an E3 ubiquitin ligase." Genes and Dev. 17(5): 581-585.
Zhang D. D., et al. (2003) "Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress." Mol. Cell. Biol. 23(22): 8137-8151.
Zhang D. D., et al. (2004) "Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex." Mol. Cell. Biol. 24(24): 10941-10953.
Zhang Y., et al. (2005) "Recognition and Ubiquitination of Salmonella Type III Effector SopA by a Ubiquitin E3 Ligase, HsRMA1." J. Biol. Chem. 280(46): 38682-38688.
Zhao H., et al. (2005) "A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation." J. Immunol. 174(9): 5288-5297.
Zhao, R., et al. (2011) “Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.” JCI, 121: 851-865.
Zhao, Y., et al. (2007). "Tumor Necrosis Factor Receptor 2 Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination and Terminates Mitogen-activated Protein Kinase Signaling." J. Biol. Chem. 282(11): 7777-7782.
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