Apoptosis / Cell Cycle
Ahlskog, J. K., et al. (2010) “Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress.” Mol. Cell. Biol. 30: 5608-5620.
Arias E. E. and Walter J.C. (2005) "Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts." Genes & Dev. 19(1): 114-126.
Auld, C. A. and R. F. Morrison (2006). "Evidence for Cytosolic p27kip1 Ubiquitylation and Degradation during Adipocyte Hyperplasia." Obesity 14: 2136-2144.
Burstein E., et al. (2004) "A novel role for XIAP in copper homeostasis through regulation of MURR1." EMBO J. 23(1): 244-254.
Choi, E. et al. (2008) "Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex." J. Biol. Chem. 283(35): 23701-23710.
Dai, M.-S., D. et al. (2006). "Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism." J. Biol. Chem. 281(34): 24304-24313.
Eguchi, H., et al. (2003). "Helicobacter pylori increases proteasome-mediated degradation of p27kip1 in gastric epithelial cells." Canc. Res. 63: 4739-4746.
Germano, S., D. et al. (2006). "Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling." J. Biol. Chem. 281: 21710-21719.
Gottifredi V., et al. (2004) "Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block." J. Biol. Chem. 279(7): 5802-5810.
Gurova K. V., et al. (2005) "Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors." PNAS 102(48): 17448-17453.
Harmey, D., et al. (2009) “The Anaphase Promoting Complex Induces Substrate Degradation during Neuronal Differentiation.” J. Biol. Chem. 284(7): 4317-4323.
Hata T., et al. (2005) "Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells." Mol. Canc. Ther. 4(10): 1585-1594.
Havens, C. G., et al. (2006). "Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell. Biol. 26(12): 4701-4711
Hedhli, N., et al. (2008) “Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload.” Am. J. Physiol. Heart. Circ. Physiol. 295 (4): H1385-H1393.
Hong, K. U., et al. (2007). "Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis ." Mol. Cell. Biol. 27(10): 3667-3681.
Huang, Y., et al. (2011) “UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.” Mol. Bio. of the Cell: doi:10.1091/mbc.E10-10-0827.
Hyuk Lee, D., et al. (2011) “The Pepper E3 Ubiquitin Ligase RING1 Gene, CaRING1, Is Required for Cell Death and the Salicylic Acid-Dependent Defense Response.” Plant Physiology 156: 2011 - 2025.
Kamynina, E., et al. (2007). "Regulation of Proto-Oncogenic Dbl by Chaperone-Controlled, Ubiquitin-Mediated Degradation” Mol. Cell. Biol. 27(5): 1809-1822.
Kops, G., et al. (2010) "APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome." J. Cell Sci. 123: 1623 - 1633.
Koshikawa N. and Takenaga K. (2005) "Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1α/Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor." Can. Res. 65(2
Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537.
Liu, Y., et al. (2007). "Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate." Canc. Res. 67(6): 2685-2692
Lolkema M.P., et al. (2005) "Tumor Suppression by the von Hippel-Lindau Protein Requires Phosphorylation of the Acidic Domain." J. Biol. Chem. 280(23): 22205-22211.
Lovly C.M., et al. (2008) "Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379." Mol. Cell. Biol. 28(19): 5874-5885.
Maynard M. A., et al. (2005) "Human HIF-3α 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma." FASEB J 19(11): 1396-1406.
Mukai A., et al. (2008) “Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.” J.Cell. Sci. 121: 1325-33.
Parcellier, A., et al. (2003). "HSP27 is a ubiquitin-binding protein involved in I-κBα proteasomal degradation." Mol. Cell. Biol. 23(11):5790-5802
Pham, L.V., et al. (2003). "Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis." J. Immunol. 171:88-95
Samuel, T., et al. (2006). "Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases." J. Biol. Chem. 281(2): 1080-1090.
Sánchez Manchinelly, S.A. (2010) “Mitotic Down-regulation of p190RhoGAP Is Required for the Successful Completion of Cytokinesis.” J. Biol. Chem. 285: 26923 - 26932.
Schmidt A., et al. (2005) "Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity." Genes & Dev. 19(4): 502-513.
Shirogane T., et al. (2005) "SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Protein." J. Biol. Chem. 280(29): 26863-26872.
Sigl, R., et al. (2009) “Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis.” J. Cell Sci. 122: 4208 - 4217.
Singh, M., et al. (2010) "Extracellular ubiquitin inhibits β-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3β and mitochondrial pathways." Cardiovasc Res. 86: 20 - 28.
Singh, M., et al. (2010) “Extracellular ubiquitin inhibits β-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3β and mitochondrial pathways.” Cardiovasc Res. 86: 20 - 28.
Song, S.J., et al. (2009) “Aurora A Regulates Pro-metaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity.” Cancer Res. 69(6): 2314-2323.
Song, S.J., et al. (2009) “Aurora A Regulates Pro-metaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity.” Cancer Res. 69(6): 2314-2323.
Su, L., et al. (2003) "p190RhoGAP is cell-cycle regulated and affect cytokinesis." J. Cell. Biol. 163(3): 571-582
Sun, L., et al. (2009) “JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.” PNAS 106: 10195-10200
Tang, W., et al. (2010) “Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box–independent Mechanism.” Mol. Biol. Cell 21: 2589 - 2597.
Uchida C., et al. (2005) "Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation." EMBO J. 24(1): 160-169.
Uchida C., et al. (2005) "Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation." EMBO J. 24(1): 160-169.
Wang, H., et al. (2011) “CCI-779 Inhibits Cell-Cycle G2–M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.” Cancer Res. 71: 4866 - 4876.
Wei, W., et al.(2004) "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase promoting complex." Nature 428: 194-198.
Williamson, A., et al. (2009) “Identification of a physiological E2 module for the human anaphase-promoting complex.” PNAS 106: 18213 - 18218.
Xu Q., et al. (2004) "Bortezomib rapidly suppresses ubiquitin thiolesterification to ubiquitin-conjugating enzymes and inhibits ubiquitination of histones and type I inositol 1,4,5-trisphosphate receptor." Mol. Cancer Ther. 3(10): 1263-1269.
Yan C., et al. (2005) "Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination." EMBO J. 24(13): 2425-2435.
Yang Q.-H. and Du C. (2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Zhu, F., et al. (2006). "COOH-Terminal Src Kinase-Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation." Cancer Res. 66(11): 5729-5736.
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