Product References

Boston Biochem’s products have been used in hundreds of UPP-related publications, below is a select reference list from 2004 to the present:
* Published online ahead of print

Apoptosis / Cell Cycle

Ahlskog, J. K., et al. (2010) “Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress.” Mol. Cell. Biol. 30: 5608-5620. Full Paper

Arias E. E. and Walter J.C. (2005) "Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts." Genes & Dev. 19(1): 114-126. Full Paper

Auld, C. A. and R. F. Morrison (2006). "Evidence for Cytosolic p27kip1 Ubiquitylation and Degradation during Adipocyte Hyperplasia." Obesity 14: 2136-2144. Full Paper

Burstein E., et al. (2004) "A novel role for XIAP in copper homeostasis through regulation of MURR1." EMBO J. 23(1): 244-254. Full Paper

Choi, E. et al. (2008) "Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex." J. Biol. Chem. 283(35): 23701-23710. Full Paper

Dai, M.-S., D. et al. (2006). "Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism." J. Biol. Chem. 281(34): 24304-24313. Full Paper

Eguchi, H., et al. (2003). "Helicobacter pylori increases proteasome-mediated degradation of p27kip1 in gastric epithelial cells." Canc. Res. 63: 4739-4746. Full Paper

Germano, S., D. et al. (2006). "Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling." J. Biol. Chem. 281: 21710-21719. Full Paper

Gottifredi V., et al. (2004) "Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block." J. Biol. Chem. 279(7): 5802-5810. Full Paper

Gurova K. V., et al. (2005) "Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors." PNAS 102(48): 17448-17453. Full Paper

Harmey, D., et al. (2009) “The Anaphase Promoting Complex Induces Substrate Degradation during Neuronal Differentiation.” J. Biol. Chem. 284(7): 4317-4323. Full Paper

Hata T., et al. (2005) "Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells." Mol. Canc. Ther. 4(10): 1585-1594. Full Paper

Havens, C. G., et al. (2006). "Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell. Biol. 26(12): 4701-4711 Full Paper

Hedhli, N., et al. (2008) “Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload.” Am. J. Physiol. Heart. Circ. Physiol. 295 (4): H1385-H1393. Full Paper

Hong, K. U., et al. (2007). "Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis ." Mol. Cell. Biol. 27(10): 3667-3681. Full Paper

Huang, Y., et al. (2011) “UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.” Mol. Bio. of the Cell: doi:10.1091/mbc.E10-10-0827. Full Paper

Hyuk Lee, D., et al. (2011) “The Pepper E3 Ubiquitin Ligase RING1 Gene, CaRING1, Is Required for Cell Death and the Salicylic Acid-Dependent Defense Response.” Plant Physiology 156: 2011 - 2025. Full Paper

Kamynina, E., et al. (2007). "Regulation of Proto-Oncogenic Dbl by Chaperone-Controlled, Ubiquitin-Mediated Degradation” Mol. Cell. Biol. 27(5): 1809-1822. Full Paper

Kops, G., et al. (2010) "APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome." J. Cell Sci. 123: 1623 - 1633. Full Paper

Koshikawa N. and Takenaga K. (2005) "Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1α/Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor." Can. Res. 65(2 Full Paper

Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537. Full Paper

Liu, Y., et al. (2007). "Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate." Canc. Res. 67(6): 2685-2692 Full Paper

Lolkema M.P., et al. (2005) "Tumor Suppression by the von Hippel-Lindau Protein Requires Phosphorylation of the Acidic Domain." J. Biol. Chem. 280(23): 22205-22211. Full Paper

Lovly C.M., et al. (2008) "Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379." Mol. Cell. Biol. 28(19): 5874-5885. Full Paper

Maynard M. A., et al. (2005) "Human HIF-3α 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma." FASEB J 19(11): 1396-1406. Full Paper

Mukai A., et al. (2008) “Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.” J.Cell. Sci. 121: 1325-33. Full Paper

Parcellier, A., et al. (2003). "HSP27 is a ubiquitin-binding protein involved in I-κBα proteasomal degradation." Mol. Cell. Biol. 23(11):5790-5802 Full Paper

Pham, L.V., et al. (2003). "Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis." J. Immunol. 171:88-95 Full Paper

Samuel, T., et al. (2006). "Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases." J. Biol. Chem. 281(2): 1080-1090. Full Paper

Sánchez Manchinelly, S.A. (2010) “Mitotic Down-regulation of p190RhoGAP Is Required for the Successful Completion of Cytokinesis.” J. Biol. Chem. 285: 26923 - 26932. Full Paper

Schmidt A., et al. (2005) "Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity." Genes & Dev. 19(4): 502-513. Full Paper

Shirogane T., et al. (2005) "SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Protein." J. Biol. Chem. 280(29): 26863-26872. Full Paper

Sigl, R., et al. (2009) “Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis.” J. Cell Sci. 122: 4208 - 4217. Full Paper

Singh, M., et al. (2010) "Extracellular ubiquitin inhibits β-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3β and mitochondrial pathways." Cardiovasc Res. 86: 20 - 28. Full Paper

Singh, M., et al. (2010) “Extracellular ubiquitin inhibits β-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3β and mitochondrial pathways.” Cardiovasc Res. 86: 20 - 28. Full Paper

Song, S.J., et al. (2009) “Aurora A Regulates Pro-metaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity.” Cancer Res. 69(6): 2314-2323. Full Paper

Su, L., et al. (2003) "p190RhoGAP is cell-cycle regulated and affect cytokinesis." J. Cell. Biol. 163(3): 571-582 Full Paper

Sun, L., et al. (2009) “JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.” PNAS 106: 10195-10200 Full Paper

Tang, W., et al. (2010) “Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box–independent Mechanism.” Mol. Biol. Cell 21: 2589 - 2597. Full Paper

Uchida C., et al. (2005) "Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation." EMBO J. 24(1): 160-169. Full Paper

Wang, H., et al. (2011) “CCI-779 Inhibits Cell-Cycle G2–M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability.” Cancer Res. 71: 4866 - 4876. Full Paper

Wei, W., et al.(2004) "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase promoting complex." Nature 428: 194-198. Full Paper

Williamson, A., et al. (2009) “Identification of a physiological E2 module for the human anaphase-promoting complex.” PNAS 106: 18213 - 18218. Full Paper

Xu Q., et al. (2004) "Bortezomib rapidly suppresses ubiquitin thiolesterification to ubiquitin-conjugating enzymes and inhibits ubiquitination of histones and type I inositol 1,4,5-trisphosphate receptor." Mol. Cancer Ther. 3(10): 1263-1269. Full Paper

Yan C., et al. (2005) "Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination." EMBO J. 24(13): 2425-2435. Full Paper

Yang Q.-H. and Du C. (2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970. Full Paper

Zhu, F., et al. (2006). "COOH-Terminal Src Kinase-Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation." Cancer Res. 66(11): 5729-5736. Full Paper

Assorted

Arnold, M. M. and Patton, J. T. (2010) “Diversity of Interferon Antagonist Activities Mediated by NSP1 Proteins of Different Rotavirus Strains.” J. Virol. 10.1128/JVI.01801-10.* Full Paper

Arun, P., et al. (2011) “Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells: Existence of Multiple Species and Membrane Localization.” PLoS one, 6: e16545. doi:10.1371/journal.pone.0016545. Full Paper

Ausseil, F., et al. (2007). "High-Throughput Bioluminescence Screening of Ubiquitin-Proteasome Pathway Inhibitors from Chemical and Natural Sources." J. Biomol. Screen. 12(1): 106-116. Full Paper

Bhandari, D., et al. (2011) “Ubiquitination of mRNA cycling sequence binding protein from Leishmania donovani (LdCSBP) modulates the RNA endonuclease activity of its Smr domain.” FEBS Letters, 585: 809-813. Full Paper

Capodagli, G., et al. (2011) “Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with covalently bonded ubiquitin.” Journal of Virology, 85: 3621-3630. Full Paper

Cosper, P. and Leinwand, L. (2011) “Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner.” Cancer Research, 71: 1710. Full Paper

Dolan, P.J. and Johnson, G. “A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway.” J. Biol. Chem. 285: 21978 - 21987. Full Paper

Esposito, K., et al. (2008) "Rosiglitazone cools down Inflammation in the Metabolic Syndrome." Arterioscler. Thromb. Vasc. Biol. 26: 1413-1414. Full Paper

Gannavaram, S., et al. (2011) “Mitochondrial Associated Ubiquitin Fold Modifier-1 Mediated Protein Conjugation in Leishmania donovani.” PLoS one 6: e16156. doi:10.1371/journal.pone.0016156 Full Paper

Graham, R., et al. (2008) "Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein." J. Gen. Virol. 81: 1913-1925. Full Paper

Griebenow, M, et al. (2007) "Ubiquitin reduces contusion volume after controlled cortical impact injury in rats." J. Neurotrauma 24(9): 1529-1535. Full Paper

Guo, W., et al. (2006). "Ubiquitin-Proteasome Pathway Function Is Required for Lens Cell Proliferation and Differentiation." Invest. Ophth. Vis. Sci. 47(6): 2569-2575. Full Paper

Kavazis, A. N., et al. (2010) “Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72.” Am. J. Physiol. Heart Circ. Physiol. 299: H1515-H1524. Full Paper

Kim, Y., et al (2011) “Mutations of the SLX4 gene in Fanconi anemia.” Nature Genetics, 43, 142-146. Full Paper

Lin, JH-C., et al. (2008) "A Central Role of Connexin 43 in Hypoxic Preconditioning." J. Neurosci. 28: 681-95. Full Paper

Link, M. A., et al. (2007). "Cathepsin B Mediates Cleavage of Herpes Simplex Virus Type 1 Origin Binding Protein (OBP) To Yield OBPC-1, and Cleavage Is Dependent upon Viral DNA Replication."J. Virol. 81(17): 9175-9182 Full Paper

Maccario, H., et al. "Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress." J. Biol. Chem. 285: 12620 – 12628. Full Paper

Mansouri, M., et al. (2008) "Remodeling of endothelial adherens junctions by Kaposi's sarcoma herpesvirus." J. Virol. 82(19):9615-9628 Full Paper

Marfella, R., et al. (2008) "Effects of Ubiquitin-Proteasome System Deregulation on the Vascular Senescence and Atherosclerosis Process in Elderly Patients." J. Gerontol. A Biol. Sci. Med. Sci. 63: 200-3. Full Paper

McClung, J.M., et al. (2008) Redox regulation of diaphragm proteolysis during mechanical ventilation. Am J Physiol Regulatory Integrative Comp Physiol: 294(5):R1608-1617 Full Paper

Merbl, Y. and Kirschner M.W. (2009) "Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays." PNAS 10 (8): 2543-2548. Full Paper

Mitra, S., et al. (2009) "Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease." J. Biol. Chem. 284(7): 4398-4403. Full Paper

Pacheco, C.D., et al. (2009) "Tau deletion exacerbates the phenotype of Niemann–Pick type C mice and implicates autophagy in pathogenesis." Hum. Mol. Genet. 18(5): 956-965. Full Paper

Page, E.L., et al. (2008) "Hypoxia-inducible Factor- α Stabilization in Non-hypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion." Mol. Biol. Cell 19: 86-94. Full Paper

Saini, V. et al (2011) “The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions.” J. Biol. Chem. 286: 33466 - 33477. Full Paper

Sampathu, D.M., et al. (2003) "Ubiquitination of α-synuclein is not required for formation of pathological inclusions in α--Synucleinopathies." Am. J. Path. 163: 91-100. Full Paper

Sato K., et al. (2004) "Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel." J. Biochem. (Tokyo) 136(6): 777-785. Full Paper

Shen, H-W., et al. (2009) "Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats." J. Neurosci. 29 (9): 2876-2884 Full Paper

Solis, M., et al. (2011) “RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I.” Journal of Virology, 85: 1224-1236.

Song, M., et al. (2011) “Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner.” Cell, 144: 187-199. Full Paper

Sparks, S. E., et al. (2005) "Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy." Glycobiology 15(11): 1102-1110. Full Paper

Vazeille, E., et al. (2008) "The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially down-regulated during recovery after immobilization-induced muscle atrophy." Am. J. Physiol. Endocrinol .Metab. 295(5): E1181-E1190. Full Paper

Weinert, B., et al (2011) “Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation.” Sci. Signal. 4: ra48. Full Paper

Wojdyla, J. A., et al. (2010) “Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates” J. Virol. 84: 10063-10073. Full Paper

Wu, K., et al. (2011) “Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1.” J. Biol. Chem. 286: 34060 - 34070. Full Paper

Yan, Z., et al. (2006). "Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia." J. Biol. Chem. 281(40): 29684-29692. Full Paper

Yuksek, K., et al. (2009) "Ubiquitin-Independent Degradation of Hepatitis C Virus F Protein." J. Virol. 83(2): 612-621. Full Paper

Zhu, F., et al. (2011) “Phosphorylation of H2AX at Ser139 and a New Phosphorylation Site Ser16 by RSK2 Decreases H2AX Ubiquitination and Inhibits Cell Transformation.” Cancer Research, 71: 393. Full Paper

Zhu, M., et al. (2011) “Pheromone- and RSP5-dependent Ubiquitination of the G Protein β Subunit Ste4 in Yeast.” J. Biol. Chem. 286: 27147 - 27155. Full Paper

Zollars, E. S., et al. (2006). "Simple electrostatic model improves designed protein sequences." Protein Sci. 15(8): 2014-2018. Full Paper

Cullins

Banerjee, S., et al. (2010) “Modulation of SCFβ-TrCP-dependent IB Ubiquitination by Hydrogen Peroxide.” J. Biol. Chem. 285: 2665 - 2675. Full Paper

Bibeau-Poirier, A., S.-P. Gravel, et al. (2006). "Involvement of the I{kappa}B Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation." J. Immunol. 177(8): 5059-5067. Full Paper

Christopher, B., et al. (2009) “The EBV Deubiquitinating Enzyme, BPLF1, Reduces EBV Ribonucleotide Reductase Activity.” J. Virol. JVI.02195-08v1 Full Paper

Furukawa, M. and Xiong Y. (2005) "BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase." Mol. Cell. Biol. 25(1): 162-171. Full Paper

Gallegos J.R., et al. (2008) “SCF TrCP1 Activates and Ubiquitylates TAp63γ.” J. Biol. Chem. 283: 66-75. Full Paper

Hernandez-Munoz I., et al. (2005) "From the Cover: Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase." PNAS 102(21): 7635-7640. Full Paper

Hiramatsu, Y., K. Kitagawa, et al. (2006). "Degradation of Tob1 Mediated by SCFSkp2-Dependent Ubiquitination." Cancer Res. 66(17): 8477-8483. Full Paper

Horn P. J., et al. (2005) "A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation." Genes & Dev. 19(14): 1705-1714. Full Paper

Isobe, T., et al. (2009) “Adenovirus E1A Inhibits SCFFbw7 Ubiquitin Ligase.” J. Biol. Chem. 284: 27766 - 27779. Full Paper

Ji, P., et al. (2006). "Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27kip1." J. Biol. Chem. 281(33): 24058-24069. Full Paper

Kim, A.Y., et al. (2008) “SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation.” J. Biol. Chem. 283(48): 33211-33220. Full Paper

Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1." Mol. Cell. Biol. 26(4): 1235-1244. Full Paper

Maerki, S., et al. (2009) “The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis.” J. Cell Biol. 187: 791 - 800. Full Paper

Menon S., et al. (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.” BMC Biochem. 9:1 Full Paper

Meyer-Schaller, N., et al. (2009) “The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.” PNAS 106: 12365 - 12370. Full Paper

Ohh, M.., et al. (2002). "An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.” EMBO Reports 3(2): 177-182. Full Paper

Pick, E., et al. (2007). "Mammalian DET1 Regulates Cul4A Activity and Forms Stable Complexes with E2 Ubiquitin-Conjugating Enzymes.” Mol. Cell. Biol. 27(13): 4708-4719. Full Paper

Sakamoto, K.M., et al. (2003). "Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation.” Mol. Cell. Proteomics 2: 1350-1358. Full Paper

Skaar, J. R., et al. (2007). "PARC and CUL7 Form Atypical Cullin RING Ligase Complexes.” Cancer Res. 67(5): 2006-2014. Full Paper

Wang W., et al. (2004) "Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail." J. Biol. Chem. 279(49): 51362-51369. Full Paper

Yamoah K., et al. (2008) "Molecular and Biochemical Characterization of the Skp2-Cks1 Binding Interface." PNAS 105(34):12230-12235. Full Paper

Deconjugating Enzymes

Amsel A.D., et al. (2008) ‘Regulation of the pro-apoptotic factor Bax by Ku70-dependent deubiquitylation.’ PNAS 105: 5117-22. Full Paper

Artavanis-Tsakonas, K., et al. (2010) “Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3.” J. Biol. Chem. 285: 6857 - 6866. Full Paper

Avvakumov, G. V., et al. (2006). "Amino-terminal dimerization, NRDP1 (FLRF) - rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin specific protease 8 (USP8/UBPY)." J. Biol. Chem.281(49):38061-38070. Full Paper

Barretto N., et al. (2005) "The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity." J. Virol. 79(24): 15189-15198. Full Paper

Bellare, P. et al. (2006). "Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p." RNA 12(2): 292-302. Full Paper

Burnett, B. et al. (2003). "The polyglutamine neurodegenerative protein Ataxin-3 binds poly-ubiquitinated proteins and has ubiquitin protease activity." Hum. Mol. Genet. 12(23): 3195-3205. Full Paper

Catic A., et al. (2007) "Screen for ISG15-cross-reactive Deubiquitinases." PLoS ONE 2(7): E769. Full Paper

Chen, Z., Y. Wang, et al. (2007). "Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63." J. Virol. 81(11): 6007-6018. Full Paper

Clementz, M.A., et al. (2010) "Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases." J. Virol. 84: 4619 - 4629. Full Paper

Cohn, M.A., et al. (2009) "UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes." J. Biol. Chem. 284 (8): 5343-5351 Full Paper

Colland, F., et al. (2009) “Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.” Mol. Cancer Ther. 8: 2286 - 2295. Full Paper

Cotto-Rios, X.M., et al. (2011) “APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.” J. Cell Biol. 194: 177 - 186. Full Paper

Das, C., et al. (2006). "Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1." PNAS 103(12): 4675-4680. Full Paper

Doss-Pepe, E.W., et al. (2003). "Ataxin-3 interactions with Rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis." Mol. Cell. Biol 23(18): 6469-6483 Full Paper

Durcan, T.M., et al. (2011) “The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.” Human Molecular Genetics, 20: 141-154. Full Paper

Evans, P.C., et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival has de-ubiquitination activity." Biochem. J. 378: 727-734. Full Paper

Faustrup, H., et al. (2009) "USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin." J. Cell Biol. 184(1):13-19. Full Paper

Felle, M., et al. (2011) “The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.” Nucleic Acids Res. 10.1093/nar/gkr528. Full Paper

Feng, L., et al. (2010) “The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments.” J. Biol. Chem. 285: 30982-30988. Full Paper

Gallery, M., J. L. Blank, et al. (2007). "The JAMM motif of human deubiquitinase Poh1 is essential for cell viability." Mol. Cancer Ther. 6(1): 262-268. Full Paper

Guo, Y., et al. (2010) “Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RAR and Inhibits the Growth of Acute Promyelocytic Leukemia.” Cancer Res. 70: 9875-9885. Full Paper

Huang, Z., et al. (2011) “Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.” Nature Cell Biology, 13: 142-152. Full Paper

James, T., et al. (2011) “Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.” PNAS, 108: 2222-2227. Full Paper

Kabuta T., et al. (2008). "Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1." Hum. Mol. Genet. 17(10):1482-1496. Full Paper

Kee, Y., et al. "WDR20 Regulates Activity of the USP12•UAF1 Deubiquitinating Enzyme Complex." J. Biol. Chem. 285: 11252 - 11257. Full Paper

Kee, Y., et al. (2006). "The Ubp2 deubiquitinating enzyme modulates Rsp5-dependent K63-linked polyubiquitin conjugates in Saccharomyces cerevisiae." J. Biol. Chem. 286: 36724-36731. Full Paper

Kim, E.T., et al. (2009) “Cleavage Specificity of the UL48 Deubiquitinating Protease Activity of Human Cytomegalovirus and the Growth of an Active-Site Mutant Virus in Cultured Cells.” J. Virol. 83: 12046 - 12056. Full Paper

Koulich, E., et al. (2008) ‘Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome.’ Mol. Biol. Cell 19: 1072-82. Full Paper

Le Negrate, G., et al. (2008) ‘Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and Modulates Innate Immune Responses.’ J. Immunol. 180: 5045-56. Full Paper

Liang, J., et al. (2010) “MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-B signaling.” J. Exp. Med. 207: 2959-2973. Full Paper

Lima, C.D. and Reverter, D. (2008) "Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7." J. Biol. Chem. 283 (46): 32045-32055. Full Paper

Lindner H. A., et al. (2005) "The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus is a Deubiquitinating Enzyme." J. Virol. 79(24): 15199-15208. Full Paper

Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol. 26(11): 4122-4133. Full Paper

Lui, T., et al. (2011) “The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/-catenin signaling.” Molecular and Cellular Biology: doi:10.1128/MCB.01094-10. Full Paper

McCullough J., et al. (2004) "AMSH is an endosome-associated ubiquitin isopeptidase." J. Cell Biol. 166(4): 487-492. Full Paper

Misaghi. S, et al. (2009) "Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1." Mol. Cell. Biol. MCB.01517-08v1 Full Paper

Mizuno, E., et al. (2005) "Regulation of Epidermal Growth Factor Receptor Down-Regulation by UBPY-mediated Deubiquitination at Endosomes." Mol. Biol. Cell 16(11): 5163-5174. Full Paper

Nakamura, M. N. Tanaka, et al. (2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes." Genes Cells 11(6): 593-606. Full Paper

Nicholson, B., et al. (2008). "Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities." Prot. Sci. 17: 1035-1043. Full Paper

Oberfeld, B., et al. (2011) “Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.” Am J Physiol Renal Physiol. 301: F189 - F196. Full Paper

Osaka, H., et al. (2003). "Ubiquitin carboxyl-terminal hydrolases L1 binds to and stabilizes monoubiquitin in neuron." Hum. Molec. Genet. 12: 1945-1958. Full Paper

Patterson-Fortin, J., et al. (2010) “Differential Regulation of JAMM Domain Deubiquitinating Enzyme Activity within the RAP80 Complex.” J. Biol. Chem. 285: 30971-30981. Full Paper

Pierre, S., et al. (2008) "Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) during Spinal Nociceptive Processing." Mol. Cell. Proteomics 7(12): 2475-2485. Full Paper

Popp, M.W., et al. (2009) "Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations." J. Biol. Chem. 284 (6): 3593-3602. Full Paper

Ratia, K, et al. (2008). "A non-covalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication." PNAS 105 (42): 16119-16124 Full Paper

Row, P. E., H. Liu, et al. (2007). "The MIT domain of UBPY constitutes a CHMP binding and endosomal localisation signal required for efficient EGF receptor degradation." J. Biol. Chem.: 282:30929-30937. Full Paper

Rytkonen, A., et al. (2007) "SseL, a Salmonella deubiquitinase required for macrophage killing and virulence4." PNAS 104(9): 3502-3507. Full Paper

Sakurai, M., et al. (2006) "Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation." J. Cell Sci. 119(1): 162-171. Full Paper

Scortegagna, M., et al. (2011) “USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains.” J. Biol. Chem. 286: 27333 - 27341. Full Paper

Shanks. J., et al. (2009) "Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages." Infect. Immun. 77 (4): 1636-1648. Full Paper

Shenoy, S.K., et al. (2009) "b-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." PNAS 106: 6650-6655 Full Paper

Shi, C. and Kehrl, J.H. (2010) “TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy.” Sci. Signal. 3: ra42. Full Paper

Song, E.J., et al. (2010) “The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.” Genes & Dev. 24: 1434 - 1447. Full Paper

Stanisic, V., et al (2009) "OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER)a and Affects ERa Transcriptional Activity. J. Biol. Chem. 284: 16135-16145 Full Paper

Sun, H., et al. (2011) “Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.” Blood, 117: 3151-3162. Full Paper

Sun, Z., et al. (2010) “The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions.” J. Virol. 84: 7832 - 7846. Full Paper

Takeyama, K., et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity." J. Biol. Chem. 278(24): 21930-21937. Full Paper

Todi, S. V., et al. (2007). "Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity." J. Biol. Chem.: 282(40): 29348-29358. Full Paper

Tzimas C, et al. (2006) "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Cell. Signal. 18(1):83-92. Full Paper

Whitehurst, C.B., et al. (2009) "The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity." J. Virol. 83: 4345-4353 Full Paper

Winborn, B.J., et al. (2008) "The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits K63-linkages in mixed linkage ubiquitin chains." J. Biol. Chem. 283(39):26436-26443 Full Paper

Xu, G., et al. (2010) “Ubiquitin-specific Peptidase 21 Inhibits Tumor Necrosis Factor -induced Nuclear Factor B Activation via Binding to and Deubiquitinating Receptor-interacting Protein 1.” J. Biol. Chem. 285: 969 - 978. Full Paper

Xu, S., et al. (2007). "Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase." J. Biol. Chem. 282(21): 15462-15470. Full Paper

Ye, Z., et al. (2007) "Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination." Am. J. Pathol. 171: 882-892. Full Paper

Yi, Y.-J., et al. (2007). "Ubiquitin C-Terminal Hydrolase-Activity Is Involved in Sperm Acrosomal Function and Anti-Polyspermy Defense During Porcine Fertilization." Biol. Reprod.77:780-793. Full Paper

Yu, H., et al. (2010) “The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and is a Critical Regulator of Gene Expression.” Mol. Cell. Biol. 10.1128/MCB.00396-10. Full Paper

Yu, H., et al. (2010) “The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression.” Mol. Cell. Biol. 30: 5071-5085. Full Paper

Zhou H., et al. (2005) "Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation." J. Exp. Med. 202(10): 1327-1332. Full Paper

Zou, C., et al. (2011) “LPS Impairs Phospholipid Synthesis by Triggering β-Transducin Repeat-containing Protein (β-TrCP)-mediated Polyubiquitination and Degradation of the Surfactant Enzyme Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (LPCAT1).” The Full Paper

E3 Ligases

*Nakao, R., et al. (2009) "Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading." Mol. Cell. Biol.: MCB.01347-08. Full Paper

Abramovitch, R. B., et al. (2006). "Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity." PNAS 103(8): 2851-2856. Full Paper

An, J.Y., et al. (2010) “UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.” PNAS 107: 1912 - 1917. Full Paper

Arimoto, K.-I., et al. (2010) “Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.” PNAS 107: 15856-15861. Full Paper

Balastik, M., et al. (2008) "Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration." PNAS 105 (33): 12016-12021. Full Paper

Barajas, D., et al. (2009) “The Nedd4-Type Rsp5p Ubiquitin Ligase Inhibits Tombusvirus Replication by Regulating Degradation of the p92 Replication Protein and Decreasing the Activity of the Tombusvirus Replicase.” J. Virol. 83: 11751 - 11764 Full Paper

Bartee E., et al. (2004) "Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins." J. Virol. 78(3): 1109-1120. Full Paper

Bernal-Bayard, J. and Ramos-Morales, F. (2009) “Salmonella Type III Secretion Effector SlrP Is an E3 Ubiquitin Ligase for Mammalian Thioredoxin.” J. Biol. Chem. 284: 27587 - 27595. Full Paper

Bottomley M., et al. (2005) "NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1): Insights into Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Apeced) Disease." J. Biol. Chem. 280(12): 11505-11512. Full Paper

Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear RING Domain Protein with Functional Connections to Chromatin Modification in Saccharomyces cerevisiae." Mol. Cell. Biol. 27(8): 2800-2811 Full Paper

Brooks, W.S., et al. (2008) "G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development." J. Biol. Chem. 283(32): 22304-22315. Full Paper

Bunce, M.W., et al. (2008) "Coordinated Activation of the Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of Phosphatidylinositol 5-Phosphate." J. Biol. Chem. 283: 8678-8686. Full Paper

Burnett, B. G. and Pittman R.N. (2005) "The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation." PNAS 102(12): 4330-4335. Full Paper

Burns, M., et al. (2009) "Parkin promotes intracellular Aβ1–42 clearance." Hum. Mol. Genet. 18: 3206 - 3216. Full Paper

Butler, M. P., et al. (2007). "Kinase active IRAKs promote polyubiquitination and degradation of the Pellino family: Direct evidence for Pellino proteins being E3 ubiquitin ligases." J. Biol. Chem. 282:29729-29737. Full Paper

Canning, M., et al. (2004) "A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7." J. Biol. Chem. 279(37): 38160-38168. Full Paper

Cao, X., et al. (2011) “WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27 Kip1 Degradation in Human Diploid Fibroblasts.” J. Biol. Chem. 286: 33447 - 33456. Full Paper

Chen, A., et al. (2009) “The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination.” Mol. Cell. Biol. 29: 5348 - 5356. Full Paper

Chen, B.B., et al (2011) “Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis.” Molecular and Cellular Biology: doi:10.1128/MCB.00723-10.” Full Paper

Cheng, P., et al. (2011) “Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development.” Neuron, 69: 231-243. Full Paper

Choi, D.W., et al. (2008) "Ubiquitination and Degradation of Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box Protein WSB-1." J. Biol. Chem. 283: 4682-4689. Full Paper

Choi, Y. et al. (2010) "The Human Cdc34 Carboxyl Terminus Contains a Non-covalent Ubiquitin Binding Activity That Contributes to SCF-dependent Ubiquitination." J. Biol. Chem. 285: 17754 - 17762. Full Paper

Clapp, K. M., et al. (2010) “C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination.” J. Biol. Chem. 285: 33642-33651. Full Paper

Cohen, S., et al. (2009) "During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation." J. Cell Biol. 185: 1083-1095 Full Paper

Cooper E. M., et al. (2004) "Biochemical Analysis of Angelman Syndrome-associated Mutations in the E3 Ubiquitin Ligase E6-associated Protein." J. Biol. Chem. 279(39): 41208-41217. Full Paper

Cooper, E.M., et al. (2009) "K63-specific deubuiquitination by two JAMM/MPN+ complexes:BRISC-associated Brcc-36 and proteasomal Poh1." EMBO J. 28(6) 621-631 Full Paper

Corcoran, C., et al. (2009) “Identification and Characterization of Two Novel Isoforms of Pirh2 Ubiquitin Ligase That Negatively Regulate p53 Independent of RING Finger Domains.” J. Biol. Chem. 284: 21955 – 21970 Full Paper

Cotto-Rios, X.M., et al. (2011) “APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.” J. Cell Biol. 194: 177 - 186. Full Paper

Dasgupta A., et al. (2004) "Sir Antagonist 1 (San1) Is a Ubiquitin Ligase." J. Biol. Chem. 279(26): 26830-26838. Full Paper

DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl. Physiol. 98(4): 1314-1321. Full Paper

Doss-Pepe E. W., et al. (2005) "α-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains." J. Biol. Chem. 280(17): 16619-16624. Full Paper

Dul, B. E. and N. C. Walworth (2007). "The Plant Homeodomain Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase Activity." J. Biol. Chem. 282(25): 18397-18406. Full Paper

Ensminger, A. and Isberg, R. (2010) “E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.” Infect. Immun., 78: 3905 - 3919. Full Paper

Ensminger, A. W. and Isberg, R. R. (2010) “E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates.” Infect. Immun. 78: 3905-3919. Full Paper

Enzler, T., et al. (2009) “MEKK1 Binds HECT E3 Ligase Itch by Its Amino-Terminal RING Motif to Regulate Th2 Cytokine Gene Expression.” J. Immunol. 183: 3831 - 3838. Full Paper

Espinosa, A., et al. (2006). "The Sjogren's Syndrome-Associated Auto-antigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death." J. Immunol. 176(10): 6277-6285. Full Paper

Everett, R.D., et al. (2010) "Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins." J. Virol. 84: 3476 - 3487. Full Paper

Everett, R.D., et al. (2010). "Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins."J. Virol. 84: 3476 - 3487. Full Paper

Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am. J. Physiol.Reg.Integ. Comp. Physiol. 290(6): R1589-1597. Full Paper

Feltham, R., et al. (2011) “SMAC-mimetics activate the E3 ligase activity of cIAP1 by promoting RING dimerisation.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M111.222919. Full Paper

Fielitz, J., et al. (2007). "Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3." J. Clin. Inv. 117(9): 2486-2495. Full Paper

Fortier, J. M. and J. Kornbluth (2006). "NK Lytic-Associated Molecule, Involved in NK Cytotoxic Function, Is an E3 Ligase." J. Immunol. 176(11): 6454-6463. Full Paper

Fotia, A.B., et al. (2005). "The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities." Intl. J. Biochem. Cell. Biol. 38(3): 472-479. Full Paper

Fouladkou, F., et al. (2010) “The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-.” J. Biol. Chem. 285: 6770 - 6780. Full Paper

Fu, W., et al. (2009) "MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation." J. Biol. Chem. 284: 13987-14000. Full Paper

Geng, L., et al. (2010) “RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.” J. Cell Biol. 191: 249-257. Full Paper

Gentry M. S., et al. (2005) "From The Cover: Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin." PNAS 102(24): 8501-8506. Full Paper

Goto, E., et al. (2003). "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." J. Biol. Chem. 278(17): 14657-14668. Full Paper

Habelhah H., et al. (2004) "Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB." EMBO J. 23(2): 322-332. Full Paper

Hadian, K., et al. (2011) “NF-B Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-B Activation.” J. Biol. Chem. 286: 26107 - 26117. Full Paper

Hallows, K.R., et al. (2010) “Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na+ Channel.” J. Biol. Chem. 285: 21671 - 21678. Full Paper

Hattori, T., et al. (2007) "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27kip1." Can. Res. 67: 10789-10795. Full Paper

He, F., B. J. Fenner, et al. (2006). "White Spot Syndrome Virus Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates Degradation of a Host Tumor Suppressor via Ubiquitination." J. Virol. 80(8): 3884-3892. Full Paper

Herman, A., et al. (2011) “Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay.” Cancer Discovery 1: 312 - 325. Full Paper

Hodson, C., et al. (2011) “Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway.” J. Biol. Chem. 286: 32628 - 32637. Full Paper

Hrecka, K., M. Gierszewska, et al. (2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle." PNAS 104(28): 11778-11783. Full Paper

Hsia, M. M. and Callis, J. (2010) “BRIZ1 and BRIZ2 Proteins Form a Heteromeric E3 Ligase Complex Required for Seed Germination and Post-germination Growth in Arabidopsis thaliana.” J. Biol. Chem. 285: 37070-37081 Full Paper

Hu S. and Yang X. (2003). "Cellular inhibitor of apoptosis1 and 2 are ubiquitin ligase for the apoptosis inducer Smac/DIABLO." J. Biol. Chem. 278(12): 10055-10060. Full Paper

Jang I.-C., et al. (2005) "HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling." Genes & Dev. 19(5): 593-602. Full Paper

Jin, X, et al. (2010) “An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-B-inducing Kinase via Lys63-linked Ubiquitination.” J. Biol. Chem. 285: 30539-30547. Full Paper

Jo, Y., et al. (2011) “Membrane-associated Ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M110.211326.” Full Paper

Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels." Mol. Biol. Cell 18(8): 3105-3118. Full Paper

Jones, J., et al. (2011) “The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.” Immunology Letters, 2: 156-162. Full Paper

Kalia, L.V., et al. (2011) “Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5).” PloS one, 6: e14695. doi:10.1371/journal.pone.0014695 Full Paper

Kawahara, K., et al. (2008) α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution: ROLE " IN THE PATHOGENESIS OF PARKINSON DISEASE." J. Biol. Chem. 283: 6979-6987. Full Paper

Kee Y., et al. (2005) "The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme." EMBO J. 24(13): 2414-2424. Full Paper

Kigoshi, Y., et al. (2011) “Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation.” J. Biol. Chem. 286: 33613 - 33621. Full Paper

Kim, D. (2010) “The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA.” Mol. Cell. Biol. 30: 4120 - 4133. Full Paper

Kim, D. H., et al. (2010) “The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA.” Mol. Cell. Biol. 30: 4120-4133. Full Paper

Kim, H.C. and J.M. Huibregtse (2009) "Poly-ubiquitination by HECT E3s and the Determinants of Chain Type Specificity." Mol. Cell. Biol. 29: 3307-3318. Full Paper

Kim, J., et al (2011) “Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus.” J. Virol. 85: 8116 - 8132. Full Paper

Koh, M.Y., et al. (2008) "Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1, Leading to Its Oxygen-Independent Degradation." Mol. Cell. Biol. 28 (23):7081-7095. Full Paper

Koike, A, et al. (2010) “Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates.” Cancer Res. 70: 6746 - 6756. Full Paper

Koike, A., et al. (2010) “Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates.” Cancer Res. 70: 6746-6756. Full Paper

Kong, H. J., et al. (2007). "Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages." J. Immunol. 179(1): 26-30. Full Paper

Koutelou, E., et al. (2008) "Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1." J. Biol. Chem. 283: 3846-53. Full Paper

Kraft E., et al. (2005) "Genome Analysis and Functional Characterization of the E2 and RING-Type E3 Ligase Ubiquitination Enzymes of Arabidopsis." Plant Physiology 139(4): 1597-1611. Full Paper

Kus B., et al. (2005) "A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5." J. Biol. Chem. 280(33): 29470-29478. Full Paper

Laine, A., I., et al. (2006). "Regulation of p53 Localization and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.

Lamothe, B., et al. (2007). "Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation." J. Biol. Chem. 282(6):Determinant of I 4102-4112. Full Paper

Li, X.S., et al. (2010) "Mammalian SWI/SNF-A Subunit BAF250/ARID1 Is an E3 Ubiquitin Ligase That Targets Histone H2B." Mol. Cell. Biol. 30: 1673 - 1688. Full Paper

Lilley B. N. and Ploegh H.L (2005) "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." PNAS 102(40): 14296-14301. Full Paper

Lin, D., et al. (2011) “Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase from Escherichia coli O157:H7.” The Journal of Biological Chemistry, 286: 441-449. Full Paper

Liu, L-J., et al. (2008) "COP1-Mediated Ubiquitination of CONSTANS Is Implicated in Cryptochrome Regulation of Flowering in Arabidopsis." Plant Cell. 20: 292-306. Full Paper

Liu, Z., et al. (2009) "Human BRE1 Is an E3 Ubiquitin Ligase for Ebp1 Tumor Suppressor." Mol. Biol. Cell 20 (3): 757-768. Full Paper

Lo, S.-C. and M. Hannink (2006). "PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex." J. Biol. Chem.: 281:37893-37903. Full Paper

Lu, J., et al. (2011) “RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation.” J. Biol. Chem. 286: 24426 - 24433. Full Paper

Lu, K., et al. (2011) “Pivotal role of the SMURF1 C2 domain in substrate selection.” The Journal of Biological Chemistry: doi:10.1074/jbc.M110.211979. Full Paper

Lu, Z., et al. (2007). "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction." J. Cell Biol. 177(6): 1077-1081 Full Paper

Lui, Q.Y., et al. (2008). "A novel brain-enriched E3 ubiquitin ligase RNF182 is up-regulated in the brains of Alzheimer’s patients and targets ATP6VOC for degradation." Molec. Degen. 3:4. Full Paper

Luke-Glaser S., et al. (2007). "CIF-1, a Shared Subunit of the COP9/Signalosome and Eukaryotic Initiation Factor 3 Complexes, Regulates MEL-26 Levels in theCaenorhabditis elegans Embryo." Mol. Cell. Biol. 27(12): 4526-4540. Full Paper

Luo, H., et al. (2010) “The Arabidopsis Botrytis Susceptible1 Interactor Defines a Subclass of RING E3 Ligases That Regulate Pathogen and Stress Responses.” Plant Physiology 154: 1766-1782. Full Paper

Maguire M., et al. (2008) "MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination." Canc. Res. 68: 3232-3242. Full Paper

Malakhova O.A. and Zhang D-E. (2008) "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response." J. Biol. Chem. 283: 8783-8787. Full Paper

Mansouri, M., et al. (2006). "Kaposi sarcoma herpes virus K5 removes CD31/PECAM from endothelial cells." Blood 108(6): 1932-1940. Full Paper

Mao, X,. et al. (2009) "GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kB/RelA." Genes & Dev. 23: 849-861. Full Paper

Mao, X., et al. (2011) “COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding.” J. Biol. Chem. 286: 32355 - 32365. Full Paper

Marblestone, J. G., et al. (2010) “Novel Approach for Characterizing Ubiquitin E3 Ligase Function.” J. Biomol. Screen. 15: 1220-1228. Full Paper

Marteijn J. A. F., et al. (2005) "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." Blood 106(13): 4114-4123. Full Paper

Meisenberg, C., et al. (2011) “Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.” Nucleic Acids Res. 10.1093/nar/gkr744. Full Paper

Miao, H., et al. (2010) "Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2."Acta Biochim Biophys Sin. 42: 303 - 310. Full Paper

Miller, S. L. H., et al. (2007). "Ubiquitin-interacting Motifs Inhibit Aggregation of PolyQ-expanded Huntingtin." J. Biol. Chem. 282(13): 10096-10103. Full Paper

Misaghi, S., et al. (2009) "Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1." Mol. Cell. Biol. 29: 2181-2192. Full Paper

Miyauchi, Y., et al. (2008) "The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination." J. Biol. Chem. 283 (24):16622-16631. Full Paper

Mo, P., et al. (2010) “MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3.” J. Biol. Chem. 285: 26908 - 26915. Full Paper

Morokuma, Y., et al. (2007). "MARCH-XI, a Novel Transmembrane Ubiquitin Ligase Implicated in Ubiquitin-dependent Protein Sorting in Developing Spermatids." J. Biol. Chem. 282(34): 24806-24815. Full Paper

Mudgil Y., et al. (2004) "A Large Complement of the Predicted Arabidopsis ARM Repeat Proteins Are Members of the U-Box E3 Ubiquitin Ligase Family." Plant Physiology 134(1): 59-66. Full Paper

Mulder, K. W., A. Inagaki, et al. (2007). "Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae." Genetics 176(1): 181-192. Full Paper

Nagel, C., et al. (2011) “Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation.” J. Virol. 85: 7644 - 7657. Full Paper

Nelson, R. F., et al. (2006). "A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control." J. Biol. Chem. 281(29): 20242-20251. Full Paper

Nerenberg B. T. H., et al. (2005) "The Poxviral RING Protein p28 Is a Ubiquitin Ligase That Targets Ubiquitin to Viral Replication Factories." J. Virol. 79(1): 597-601. Full Paper

Nie, J., et al. (2010) “Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2.” J. Biol. Chem. 285: 22818 - 22830. Full Paper

Nishikawa H., et al. (2004) "Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase." J. Biol. Chem. 279(6): 3916-3924. Full Paper

Nishikawa, H., et al. (2009) "BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity." Canc. Res. 69 (1):111-119. Full Paper

Ogawa, M., et al. (2008) "Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase." Genes Cells 13: 397-409. Full Paper

Ohtsubo M., et al. (2008) "Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity." PNAS 105(30): 10396-10401. Full Paper

Olzmann, J.A., et al. (2007) "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6." J. Cell Biol. 178(6): 1025-1038. Full Paper

Pan Y. and Chen J. et al. (2003). "MDM2 promotes ubiquitination and degradation of MDMX." Mol. Cell. Biol. 23(15): 5113-5121. Full Paper

Peng H.-M., et al. (2004) "Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase." J. Biol. Chem. 279(51): 52970-52977. Full Paper

Pierre S., et al. (2008) "Toponomics analysis of functional interactions of the ubiquitin ligase PAM during spinal nociceptive processing." Mol. Cell. Proteomics. 7(12)2475-2485 Full Paper

Priest, C., et al. (2010) “Deconstructing nucleotide binding activity of the Mdm2 RING domain.” Nucleic Acids Res. 10.1093/nar/gkq669. Full Paper

Priest, C., et al. (2010) “Deconstructing nucleotide binding activity of the Mdm2 RING domain.” Nucleic Acids Res. 38: 7587-7598. Full Paper

Quezada, C.M., et al. (2009) "A family of Salmonella virulence factors functions as a distinct class of auto-regulated E3 ubiquitin ligases." PNAS 106 (12): 4864-4869. Full Paper

Rajendra R., et al. (2004) "Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53." J. Biol. Chem. 279(35): 36440-36444. Full Paper

Rakovic, A., et al. (2011) “Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts.” PLoS one, 6: e16746. doi:10.1371/journal.pone.0016746. Full Paper

Ramamoorthy, S., et al. (2010) “Isoform-Specific Degradation of PR-B by E6-AP Is Critical for Normal Mammary Gland Development.” Mol. Endocrinol. 24: 2099-2113. Full Paper

Ramamoorthy, S., et al. (2010) “Isoform-Specific Degradation of PR-B by E6-AP Is Critical for Normal Mammary Gland Development.” Mol. Endocrinol., 10.1210/me. 2010-0116. Full Paper

Ryan, P.E., et al. (2010) “The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme.” J. Biol. Chem. 285: 23687 - 23698. Full Paper

Sangadala, S., et al. (2006). "LIM Mineralization Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness via a Novel Interaction with Smurf1 Resulting in Decreased Ubiquitination of Smads." J. Biol. Chem. 281(25): 17212-17219. Full Paper

Sargin, B., C. Choudhary, et al. (2007). "Flt3-dependent transformation by inactivating c-Cbl mutations in AML." Blood 110(3): 1004-1012. Full Paper

Sasaki, M., et al. (2007). "MDM2 Binding Induces a Conformational Change in p53 That Is Opposed by Heat-shock Protein 90 and Precedes p53 Proteasomal Degradation." J. Biol. Chem. 282(19): 14626-14634. Full Paper

Scortegagna, M., et al. (2011) “USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains.” J. Biol. Chem. 286: 27333 - 27341. Full Paper

Secombe J. and Parkhurst S.M. (2004) "Drosophila Topors Is a RING Finger-containing Protein That Functions as a Ubiquitin-protein Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor Protein." J. Biol. Chem. 279(17): 17126-17133. Full Paper

Sehat B, et al. (2008). "Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis" Canc. Res. 68: 5669-5677. Full Paper

Sekine K., et al. (2008). "Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation." J. Biol. Chem. 283(14): 8961-8968. Full Paper

Shao, G., et al. (2009) "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks." Genes & Dev. 23: 740-754. Full Paper

Shi, C. and Kehrl, J.H. (2010) “TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy.” Sci. Signal. 3: ra42. Full Paper

Shibata, E., et al. (2011) “Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex.” Mol. Cell. Biol. 31: 3136 - 3145. Full Paper

Shin, J., et al. (2011) “PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease.” Cell, 144: 689-702. Full Paper

Simonin, A. and Fuster, D. (2010) “Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and Function.” J. Biol. Chem. 285: 38293-38303. Full Paper

Song, I. Y., et al. (2010) “Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway.” J. Biol. Chem. 285: 31525-31536. Full Paper

Sorkhy, M.A., et al. (2009) "The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4." J. Biol. Chem. 284(5): 2617-2627. Full Paper

Starita L. M., et al. (2004) "BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number." Mol. Cell. Biol. 24(19): 8457-8466. Full Paper

Stone S. L., et al. (2005) "Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis." Plant Physiology 137(1): 13-30. Full Paper

Sung, C.K., et al. (2011) “Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150Sal2.” The FASEB Journal fj.10-173674; published ahead of print January 12, 2011,doi:10.1096/fj.10-173674. Full Paper

Takedachi, A., et al. (2010) "DDB2 Complex-Mediated Ubiquitylation around DNA Damage Is Oppositely Regulated by XPC and Ku and Contributes to the Recruitment of XPA" Mol. Cell. Biol. 30: 2708 - 2723. Full Paper

Tatematsu, K., et al. (2008) "Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase Cβ." J. Biol. Chem. 283: 11575-85. Full Paper

Torres, M.P., et al. (2009) "G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase." J. Biol. Chem. 284 (13): 8940-8950. Full Paper

Tsz-Mei Lok, G., et al. (2011) “Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.” Nucleic Acids Res. 10.1093/nar/gkr655. Full Paper

Tursun B., et al. (2005) "The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones." Genes & Dev. 19(19): 2307-2319. Full Paper

Uchiki T., et al. (2009) "The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition." J. Biol. Chem. 284: 12622-12632. Full Paper

Umebayashi K., et al. (2008) " Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation." Mol. Biol. Cell. 19(8): 3454-3462. Full Paper

Varfolomeev E., et al. (2008) "c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α(TNFα)-induced NF-κB Activation." J. Biol. Chem. 283(36): 24295-24299. Full Paper

Vega-Sanchez M.E., et al. (2008) "SPIN1, a K Homology Domain Protein Negatively Regulated and E3 Ubiquitin Ligase SPL11, Is Involved in Flowering Time Control in Rice." Plant Cell 20: 1456-1469. Full Paper

Vichi A., et al. (2005) "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)" PNAS 102(6): 1945-1950. Full Paper

Wada K. And Kamitani T. (2006) "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself." Biochem. Biophys. Res. Comm. 342(1): 253-258. Full Paper

Walters, M.S., et al. (2010) “The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies.” J. Virol. 84: 6861 - 6865. Full Paper

Wang A.M., et al. (2010) "Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation." J. Biol. Chem. 285: 15714 - 15723. Full Paper

Wang Z., et al. (2005) "RING-H2 Protein WSSV249 from White Spot Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme, PvUbc, for Viral Pathogenesis." J. Virol. 79(14): 8764-8772. Full Paper

Wang, B., et al. (2009) "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control." Genes & Dev. 23: 729-739. Full Paper

Wang, H., et al. "Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6." J. Biol. Chem. 285: 13201 - 13210. Full Paper

Wang, X., et al. (2006). "The Viral E3 Ubiquitin Ligase mK3 Uses the Derlin/p97 Endoplasmic Reticulum-associated Degradation Pathway to Mediate Down-regulation of Major Histocompatibility Complex Class I Proteins." J. Biol. Chem. 281(13): 8636-8644. Full Paper

Wang, X., et al. (2007). "Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3." J. Cell Biol. 177(4): 613-624. Full Paper

Wang, X., et al. (2011). “MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination.” J. Biol. Chem. 286: 23725 - 23734. Full Paper

Wawrzynow, B., et al. (2009) "A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity." J. Biol. Chem. 284: 11517-11530. Full Paper

Worby, C.A., et al. (2008) "Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG)". J. Biol. Chem. 283: 4069-76. Full Paper

Wu, W., H. Nishikawa, et al. (2007). "BRCA1 Ubiquitinates RPB8 in Response to DNA Damage." Cancer Res. 67(3): 951-958. Full Paper

Yamada, M., J. Ohnishi, et al. (2006). "NARF, an emo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)." J. Biol. Chem. 281(30): 20749-20760. Full Paper

Yamauchi, K., et al. (2008). "Ubiquitination of E3 ligase TRIM5α and its potential role." FEBS J. 275(7): 1540-1555. Full Paper

Yang, M., et al. (2011) “E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC.” J. Exp. Med. 208: 2099 - 2112. Full Paper

Yang, Y., et al. (2010) “E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF-induced JNK activation.” PNAS 107: 13444 - 13449. Full Paper

Yao D., et al. (2004) "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." PNAS 101(29): 10810-10814. Full Paper

Yogosawa S., et al.. (2005) "Ubiquitylation and Degradation of Serum-inducible Kinase by hVPS18, a RING-H2 Type Ubiquitin Ligase." J. Biol. Chem. 280(50): 41619-41627. Full Paper

Yurchenko, V., et al. (2003). "The RAG1 N-terminal domain is an E3 ubiquitin ligase." Genes and Dev. 17(5): 581-585. Full Paper

Zhang D. D., et al. (2003) "Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress." Mol. Cell. Biol. 23(22): 8137-8151. Full Paper

Zhang D. D., et al. (2004) "Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex." Mol. Cell. Biol. 24(24): 10941-10953. Full Paper

Zhang Y., et al. (2005) "Recognition and Ubiquitination of Salmonella Type III Effector SopA by a Ubiquitin E3 Ligase, HsRMA1." J. Biol. Chem. 280(46): 38682-38688. Full Paper

Zhao H., et al. (2005) "A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation." J. Immunol. 174(9): 5288-5297. Full Paper

Zhao, R., et al. (2011) “Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.” JCI, 121: 851-865. Full Paper

Zhao, Y., et al. (2007). "Tumor Necrosis Factor Receptor 2 Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination and Terminates Mitogen-activated Protein Kinase Signaling." J. Biol. Chem. 282(11): 7777-7782. Full Paper

ER Trafficking / receptors / signaling

Almeida, C. G., et al. (2006). "β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System." J. Neurosci. 26(16): 4277-4288. Full Paper

Anderson, G.R., et al. (2007). " Expression and Localization of RGS9-2/Gb5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases ." J. Neurosci. 27(51): 14117-14127. Full Paper

Arimoto, K., et al. (2010) “Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.” PNAS 107: 15856 - 15861. Full Paper

Barriere, H., et al. (2007). "Plasticity of Poly-Ubiquitin Recognition as Lysosomal Targeting Signals by the Endosomal Sorting Machinery." Mol. Biol. Cell. 18(10) :3952-3965. Full Paper

Bergeron, A., et al. (2006). "Involvement of Endoplasmic Reticulum Stress in Hereditary Tyrosinemia Type I." J. Biol. Chem. 281(9): 5329-5334. Full Paper

Bulut, G., et al. (2011) “Ubiquitination Regulates the Internalization, Endolysosomal Sorting, and Signaling of the Erythropoietin Receptor.” The Journal of Biological Chemistry, 286: 6449-6457. Full Paper

Byun, H., et al. (2010) “Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function.” PNAS 107: 12287 - 12292. Full Paper

Chen, Y., et al. (2006). "Proteasome-dependent down-regulation of activated Stat5A in the nucleus." Blood 108(2): 566-574. Full Paper

Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3) Mediates Ubiquitination and Degradation of Tumor Necrosis Factor Receptor II." Mol. Cell. Biol. 25(11): 4716-4726. Full Paper

Conze, D.B., et al. (2008) “Lys63-Linked Poly-ubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation.” Mol. Cell. Biol. 28: 3538-47. Full Paper

Cordier, F., et al. (2009) “The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain.” J. Biol. Chem. 284(5): 2902-2907. Full Paper

Coulombe, P., et al. (2003) “Rapid turnover of extracellular signal-regulated Kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.” Mol. Cell. Biol. 23: 4542- Full Paper

De Schutter, J., et al. (2009) “SHIP2 (SH2 Domain-containing Inositol Phosphatase 2) SH2 Domain Negatively Controls SHIP2 Monoubiquitination in Response to Epidermal Growth Factor.” J. Biol. Chem. 284: 36062 - 36076. Full Paper

Dudek, J.M. and Horton, R.A. (2010) "TR-FRET Biochemical Assays for Detecting Posttranslational Modifications of p53." J Biomol Screen. 15: 569 - 575. Full Paper

Esposito, K., et al. (2006). "Rosiglitazone Cools Down Inflammation in the Metabolic Syndrome." Arterioscler. Thromb. Vasc. Biol. 26(6): 1413-1414. Full Paper

Floyd, Z. E., et al. (2006). "Degradation of STAT5 Proteins in 3T3-L1 Adipocytes is induced by TNFα and cycloheximide in a manner independent of STAT5A activation." Am J Physiol Endocrinol Metab: 292(2):E461-8. Full Paper

Forbes, A., et al. (2007). "The tetraspan protein EMP2 regulates expression of caveolin-1." J. Biol. Chem.: 282(36): 26542-26551. Full Paper

Fotia A. B., et al. (2004) "Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2." J. Biol. Chem. 279(28): 28930-28935. Full Paper

Fukuda, H., et al. (2006). "MARCH-III Is a Novel Component of Endosomes with Properties Similar to Those of MARCH-II." J. Biochem. (Tokyo) 139(1): 137-145. Full Paper

Habelhah H., et al. (2004) "Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB." EMBO J. 23(2): 322-332. Full Paper

Hartman, I.Z., et al. (2010) "Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets." J. Biol. Chem. 285: 19288 - 192 Full Paper

Hatao, F., et al. (2004) "Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein." J. Leukoc. Biol. 76(4): 904-908. Full Paper

Jalonen U, et al. (2008) "Compounds That Increase or Mimic Cyclic Adenosine Monophosphate Enhance Tristetraprolin Degradation in Lipopolysaccharide-Treated Murine J774 Macrophages." J. Pharm. Exp. Ther. 326: 514-522 Full Paper

Jang, I.-C., et al. (2007). "Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling." Genes & Dev. 21(16): 2100-2111. Full Paper

Kaneko, M., et al. (2010) “Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation.” J. Neurosci., 3924 - 3932. Full Paper

Kaneko-Oshikawa C., et al. (2005) "Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System." Mol. Cell. Biol. 25(24): 10953-10964.

Kim D. W., et al. (2005) "The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes." PNAS 102(39): 14046-14051. Full Paper

Kim, S. T., et al. (2006). "Exogenous Free Ubiquitin Enhances Lily Pollen Tube Adhesion to an in Vitro Stylar Matrix and May Facilitate Endocytosis of SCA (Stigma/stylar Cysteine-rich Adhesin)." Plant Physiology: 142: 984-992. Full Paper

Kostova, Z., et al. (2009) “A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.” J. Cell Sci. 122: 1374-1381. Full Paper

Kowanetz K., et al. (2004) "Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases." J. Biol. Chem. 279(31): 32786-32795. Full Paper

LaLonde, D. and Bretscher, A. (2011) “The UBX Protein SAKS1 Negatively Regulates Endoplasmic Reticulum-associated Degradation and p97-dependent Degradation.” The Journal of Biological Chemistry, 286: 4892-4901. Full Paper

Lee T. H., et al. (2004) "The Kinase Activity of Rip1 Is Not Required for Tumor Necrosis Factor-α-induced IκB Kinase or p38 MAP Kinase Activation or for the Ubiquitination of Rip1 by Traf2." J. Biol. Chem. 279(32): 33185-33191. Full Paper

Lilley B. N. and Ploegh H.L. (2005) "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." PNAS 102(40): 14296-14301. Full Paper

Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1." Mol. Cell. Biol. 26(4): 1235-1244. Full Paper

Mansouri, M., et al. Full Paper

Mansouri, M., et al. (2006). "Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells." Blood 108(6): 1932-1940. Full Paper

Marfella, R., et al. (2006). "Increased Activity of the Ubiquitin-Proteasome System in Patients With Symptomatic Carotid Disease Is Associated With Enhanced Inflammation and May Destabilize the Atherosclerotic Plaque: Effects of Rosiglitazone Treatment." Full Paper

Marfella, R., et al. (2006). "The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment." Diabetes 55(3): 622-632. Full Paper

Medina E. A., et al. (2005) "Tumor Necrosis Factor-α Decreases Akt Protein Levels in 3T3-L1 Adipocytes via the Caspase-Dependent Ubiquitination of Akt." Endocrinology 146(6): 2726-2735. Full Paper

Mizuno, E., et al. (2003) “STAM proteins bind uibuiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.” Mol. Cell. Biol. 14(9): 3675-3689. Full Paper

Nelson, R. F., et al. (2006). "A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control." J. Biol. Chem. 281(29): 20242-20251. Full Paper

Ogawa S., et al. (2004) "A nuclear receptor co-repressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation." PNAS 101(40): 14461-14466. Full Paper

Oved, S., Y. Mosesson, et al. (2006). "Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases." J. Biol. Chem. 281(31): 21640-21651. Full Paper

Saini, V., et al. (2010) "CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin." J. Biol. Chem. 285: 15566 - 15576. Full Paper

Shah, O. J. and T. Hunter (2006). "Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis." Mol. Cell. Biol. 26(17): 6425-6434. Full Paper

Song B.-L. and DeBose-Boyd R.A. (2004) "Ubiquitination of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Permeabilized Cells Mediated by Cytosolic E1 and a Putative Membrane-bound Ubiquitin Ligase." J. Biol. Chem. 279(27): 28798-28806. Full Paper

Song, B.-L. and R. A. DeBose-Boyd (2006). "Insig-dependent Ubiquitination and Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Stimulated by δ- and γ-Tocotrienols." J. Biol. Chem. 281(35): 25054-25061. Full Paper

Sun, Z., et al. (2007). "Keap1 Controls Post-Induction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2." Mol. Cell. Biol.: 27(18):6334-6349. Full Paper

Wada, K., et al. Full Paper

Wang H., et al. (2004) "Both the PPPY and PTAP Motifs Are Involved in Human T-Cell Leukemia Virus Type 1 Particle Release." J. Virol. 78(3): 1503-1512. Full Paper

Wang, X.H., et al. “Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity.” J. Biol. Chem. 285: 21249 - 21257. Full Paper

Wang, Z.Q., et al. Full Paper

Wyatt, D., et al. (2011) “Small Ubiquitin-like Modifier Modification of Arrestin-3 Regulates Receptor Trafficking.” The Journal of Biological Chemistry, 286: 3884-3893. Full Paper

Zvonic S., et al. (2005) "Cross-talk among gp130 Cytokines in Adipocytes." J. Biol. Chem. 280(40): 33856-33863.

Proteasome Degradation

*Bruce, S.R., et al (2009) "Respiratory Syncytial Virus (RSV) Infection Alters Surfactant Protein-A (SP-A) Expression in Human Pulmonary Epithelial Cells by Reducing Translation Efficiency." Am J Physiol Lung Cell Mol Physiol: 90507.2008. Full Paper

Adachi K., et al. (2004) "Ubiquitylation of Nascent Globin Chains in a Cell-free System." J. Biol. Chem. 279(40): 41767-41774. Full Paper

Alroy I., et al. (2005) "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production." PNAS 102(5): 1478-1483. Full Paper

Arastu-Kapur, S., et al. (2011) “Non-proteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events.” Clinical Cancer Research: doi: 10.1158/1078-0432.CCR-10-1950. Full Paper

Archer C.T., et al. (2008) "Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome." J. Biol. Chem. 283(31): 21789-21798. Full Paper

Archer, C. and Kodadek, T. (2010) “The hydrophobic patch of ubiquitin is required to protect transactivator–promoter complexes from destabilization by the proteasomal ATPases.” Nucleic Acids Res. 38: 789 - 796. Full Paper

Baldin, V., et al. (2008) ‘A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking.’ Mol. Biol. Cell 19: 1706-16. Full Paper

Bauer, S., et al. (2010) “Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells.” Cancer Res. 70: 150 - 159. Full Paper

Bianchi, G., et al. (2009) "The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition." Blood 113: 3040-3049. Full Paper

Burnett, B.G., et al. (2009) "Regulation of SMN Protein Stability." Mol. Cell. Biol. 29: 1107-1115. Full Paper

Burns, K.E., et al. (2009) "Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein." J. Biol. Chem. 284(5): 3069-3075. Full Paper

Chandra, A., et al. (2010) “Proteasome Assembly Influences Interaction with Ubiquitinated Proteins and Shuttle Factors.” J. Biol. Chem. 285: 8330 - 8339. Full Paper

Chen L. and Madura K. (2005) "Increased Proteasome Activity, Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor Detected in Breast Cancer Tissue." Cancer Res. 65(13): 5599-5606. Full Paper

Chen, L., et al. (2011) “Sts1 Plays a Key Role in Targeting Proteasomes to the Nucleus.” The Journal of Biological Chemistry, 286: 3104-3118. Full Paper

Chu, I., et al. (2007). "Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer." J. Clin. Invest. 117(8): 2205-2215. Full Paper

Chuang S.-M., et al. (2005) "Proteasome-Mediated Degradation of Cotranslationally Damaged Proteins Involves Translation Elongation Factor 1A." Mol. Cell. Biol. 25(1): 403-413. Full Paper

Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3) Mediates Ubiquitination and Degradation of Tumor Necrosis Factor Receptor II." Mol. Cell. Biol. 25(11): 4716-4726. Full Paper

Dasmahapatra, G., et al. (2010) "The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo." Blood. 115: 4478 - 4487. Full Paper

Demo, S. D., et al. (2007). "Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome." Cancer Res. 67(13): 6383-6391. Full Paper

Depre, C., Q. Wang, et al. (2006). "Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy." Circulation 114(17): 1821-1828. Full Paper

DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl .Physiol .98(4): 1314-1321. Full Paper

Dominy, J.E., et al. (2006). "Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat." Biochem. J. 394: 267-273. Full Paper

Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Fruh K, Moses AV. (2009) "Vpu Directs the Degradation of the HIV Restriction Factor BST-2/tetherin via a bTrCP-dependent Mechanism." J. Virol.: JVI.00242-09.* Full Paper

Drews, O., et al. (2007). "Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities." Mol. Cell. Proteomics. 6(11):2021-2031 Full Paper

Dudek E. J., et al. (2005) "Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases." FASEB J (12): 1707-9 Full Paper

Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am J Physiol Reg. Integ. Comp. Physiol. 290(6): R1589-1597. Full Paper

Ferdous, A., et al. (2007). "The role of the proteasomal ATPases and activator mono-ubiquitylation in regulating Gal4 binding to promoters." Genes & Dev. 21(1): 112-123. Full Paper

Fernandes, A., et al. (2009) “Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells.” Mol. Biol. Cell 20: 3690 - Full Paper

Fernandez, A.F., et al. (2008) " Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8." J. Biol. Chem. 283(30): 20745-20753. Full Paper

Floyd, Z. E., et al. (2007). "Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-α and cycloheximide in a manner independent of STAT5A activation." Am J Physiol Endocrinol Metab 292(2): E461-4 Full Paper

Gallagher, M. J., et al. (2007). "The GABAA receptor α1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation." PNAS 104(32): 12999-13004. Full Paper

Garza, R.M., et al. (2009) "In Vitro Analysis of Hrd1p-mediated Retrotranslocation of its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase." J. Biol. Chem. 284: 14710-14722. Full Paper

Ghaboosi, N. and R. J. Deshaies (2007). "A Conditional Yeast E1 Mutant Blocks the Ubiquitin-Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome." Mol. Biol. Cell 18(5): 1953-1963. Full Paper

Gho, A.M., et al. (2008). "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins." BMC Biochem. 9:4. Full Paper

Guo W., et al. (2004) "Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation." Invest. Ophthalmol. Vis. Sci. 45(4): 1194-1201. Full Paper

Hedhli, N., et al. (2008) ‘Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.’ Cardiovasc. Res. 77: 497-505. Full Paper

Heuzé, M.L., et al. (2008) "ASB2 targets filamins A and B to proteasomal degradation." Blood 112(13): 5130-5140. Full Paper

Ikeda, Y., et al. (2009) “Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein: p97 Recruits Proteasomes to Insig-1 Before Extraction From Membranes.” J. Biol. Chem. 284: 34889 - 34900. Full Paper

Kavazis, A. N., et al. (2007). "Diaphragmatic proteasome function is maintained in the aging Fisher 344 rat." Exp Physiol: 92(5):895-901. Full Paper

Kim, H.T.., et al. (2009) "S5a promotes protein degradation by blocking synthesis of non-degradable forked ubiquitin chains." EMBO J. 28: 1867-1877. Full Paper

Kisselev, A. F., et al. (2006). "Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate." J. Biol. Chem. 281(13): 8582-8590. Full Paper

Koodathingal, P., et al. (2009) "ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins." J. Biol. Chem. 284: 18674-18684. Full Paper

Koodathingal, P., et al. (2009) “ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins.” J. Biol. Chem. 284: 18674 - 18684. Full Paper

Korzeniewski, N., et al. (2010) “Daughter Centriole Elongation Is Controlled by Proteolysis.” Mol. Biol. Cell 21: 3942-3951. Full Paper

Kumar, B., et al. (2010) “The C Terminus of Rpt3, an ATPase Subunit of PA700 (19 S) Regulatory Complex, Is Essential for 26 S Proteasome Assembly but Not for Activation.” J. Biol. Chem. 285: 39523-39535. Full Paper

Lee, C.-M., et al. (2010) “Metabolism and Action of Proteasome Inhibitors in Primary Human Hepatocytes.” Drug Metab. Dispos. 38: 2166-2172. Full Paper

Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537. Full Paper

Lin, G., et al. (2008) "Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates." J. Biol. Chem. 283(49): 34423-34431. Full Paper

Lin, Y., et al. (2011) “The Defective Proteasome but Not Substrate Recognition Function Is Responsible for the Null Phenotypes of the Arabidopsis Proteasome Subunit RPN10.” PLANT CELL 23: 2754 - 2773. Full Paper

Liu, J., et al. (2008) "A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome." Am. J. Physiol. Heart.Circ. Physiol. 295(6): H2541-H2550. Full Paper

Marfella, R., et al. (2007). "Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin-Proteasome Activity." Hypertension 49(4): 784-791. Full Paper

Marfella, R., et al. (2008) ‘Proteasome Activity as a Target of Hormone Replacement Therapy-Dependent Plaque Stabilization in Postmenopausal Women.’ Hypertension 51: 1135-41. Full Paper

Marteijn, J. A. F., et al. (2006). "Diminished proteasomal degradation results in accumulation of Gfi1 protein levels in monocytes." Blood: 109: 100-108 Full Paper

McClung J.M., et al. (2008). "Redox regulation of diaphragm proteolysis during mechanical ventilation." Am. J. Physiol. Regul. Integ. Comp. Physiol. 294: R1608-1617. Full Paper

Mehle A., et al. (2004) "Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway." J. Biol. Chem. 279(9): 7792-7798. Full Paper

Mi, L., et al. (2011) “Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.” Carginogenesis, 32: 216-223. Full Paper

Middeldorp J., et al. (2009) "Intermediate filament transcription in astrocytes is repressed by proteasome inhibition." FASEB J: fj.08-127696.* Full Paper

Nagel, C., et al. (2011) “Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation.” J. Virol. 85: 7644 - 7657. Full Paper

Obaidat, A., et al. (2011) “Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.” Jour. of Pharm. and Exp. Therapeutics: doi:10.1124/jpet.110.177824 Full Paper

Okamura, T., et al. (2003) "Abnormally high expression of proteasome activator-γ in thyroid neoplasm." Clin. Endocrin. Metab. 88(3): 31374031383. Full Paper

Owens, L, et al. (2010) “Activation Domain-dependent Degradation of Somatic Wee1 Kinase.” J. Biol. Chem. 285: 6761 - 6769. Full Paper

Parlati, F., et al. (2009) “Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.” Blood 114: 3439 - 3447. Full Paper

Phan, V.T., et al. (2010) “The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans.” Mol. Cell. Biol. 30: 2264 - 2279. Full Paper

Reis, J., et al. (2008) "A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model." Innate Immunity 14(5): 319-329. Full Paper

Reuter C. J. and Maupin-Furlow J.A. (2004) "Analysis of Proteasome-Dependent Proteolysis in Haloferax volcanii Cells, Using Short-Lived Green Fluorescent Proteins." Appl. Envir. Microbiol. 70(12): 7530-7538. Full Paper

Rinetti, G.V. and Schweizer, F. (2010) “Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons.” J. Neurosci. 30: 3157 - 3166. Full Paper

Rousseau, E., et al. (2009) "Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones." J. Biol. Chem. 284(3): 1917-1929. Full Paper

Screen, M., et al. (2010) “Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors.” J. Biol. Chem. 285: 40125-40134. Full Paper

Shang F., et al. (2005) "Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation." J. Biol. Chem. 280(21): 20365-20374. Full Paper

Shen, H-W., et al. (2009) "Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats." J. Neurosci. 29: 28762884. Full Paper

Smith, I. J. and S. L. Dodd (2007). "Muscle: Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle." Exp Physiol 92(3): 561-573. Full Paper

Solis, M., et al. (2010) “RIG-I Mediated Antiviral Signalling is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I” J. Virol. 10.1128/JVI.01635-10.* Full Paper

Suzuki N., et al. (2004) "Proteasomal Degradation of the Nuclear Targeting Growth Factor Midkine." J. Biol. Chem. 279(17): 17785-17791. Full Paper

Tanioka, T., et al. (2011) “Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells: INVOLVEMENT OF GLYCOGEN SYNTHASE KINASE-3β.” J Full Paper

Uchida, S., et al. (2011) “SCFβTrCP mediates stress-activated MAPK-induced Cdc25B degradation.” J. Cell Sci. 124: 2816 - 2825. Full Paper

Vaziri, S., et al. Full Paper

Wang, X., et al (2010) “Regulation of the 26S Proteasome Complex During Oxidative Stress.” Sci. Signal. 3: ra88.* Full Paper

Wang, Y., et al. (2011) “The ubiquitin-dependent proteasomal degradation (UPD) of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and Ubiquitination.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M110.176685 Full Paper

Wang, Z.Q., et al. (2009) "Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys." Diabetes 58: 1488-1498. Full Paper

Wei, W., et al. (2006). "Treatment of cultured myotubes with the proteasome inhibitor β-lactone increase expression of the transcription factor C/EBPβ." Am J Physiol Cell Physiol: 292:C216-C226. Full Paper

Wherry, E. J., et al. (2006). "Re-evaluating the Generation of a "Proteasome-Independent" MHC Class I-Restricted CD8 T Cell Epitope." J. Immunol. 176(4): 2249-2261. Full Paper

Willeumier, K., et al. (2006). "Proteasome Inhibition Triggers Activity-Dependent Increase in the Size of the Recycling Vesicle Pool in Cultured Hippocampal Neurons." J. Neurosci. 26(44): 11333-11341. Full Paper

Williamson, M. J., et al. (2006). "Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib." Mol. Cancer Ther. 5(12): 3052-3061. Full Paper

Yamano T., et al. (2008) "α-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation: UNDERSTANDING THE CYTOTOXICITY OF PROTEIN PROTOFIBRILS IN NEURODEGENERATIVE DISEASE PATHOGENESIS." J. Biol. Chem. 283(29): 20288-20298. Full Paper

Yang Z., et al. (2008) Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication. J. Virol. 82: 3590-603 Full Paper

Yang, Q.-H. and Du C.(2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970. Full Paper

Yimlamai T., et al. (2005) "Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway." J Appl Physiol 99(1): 71-80. Full Paper

Zhang, N., et al. (2011) “Ubiquitin Chain Trimming Recycles the Substrate Binding Sites of the 26 S Proteasome and Promotes Degradation of Lysine 48-linked Polyubiquitin Conjugates.” J. Biol. Chem. 286: 25540 - 25546. Full Paper

Zmijewski, J., et al. (2009) “S-Glutathionylation of the Rpn2 Regulatory Subunit Inhibits 26 S Proteasomal Function.” J. Biol. Chem. 284: 22213 - 22221. Full Paper

SUMO

Benson, M. D., et al. (2007). "SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5." PNAS 104(6): 1805-1810. Full Paper

Chang, C., et al (2011) “A Novel Cyclic AMP/Epac1/CaMKI Signaling Cascade Promotes GCM1 Desumoylation and Placental Cell Fusion.” Mol. Cell. Biol. 31: 3820 - 3831. Full Paper

Chou, C.-C., et al. (2007). "SUMO modification regulates the DNA-binding activity of GCMa." J. Biol. Chem.: 282(37): 27239-27249. Full Paper

Dawlaly, M.M., et al. (2008) "Resolution of Sister Centromeres requires RanBP2-mediated SUMOylation of Topoisomerase IIα." Cell 133: 103-115. Full Paper

Galisson, F., et al. (2011) “A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells.” Molecular and Cellular Proteomics, 10: M110.004796. Full Paper

Kagey M. H., et al. (2005) "Multiple activities contribute to Pc2 E3 function." EMBO J. 24(1): 108-119. Full Paper

Lois L. M. and Lima C. D. (2005) "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1." EMBO J. 24(3): 439-451. Full Paper

MacPherson, M.J., et al. (2009) "The CTCF Insulator Protein Is Post-translationally Modified by SUMO." Mol. Cell. Biol. 29(3): 714-725. Full Paper

Mullen, J.R., et al. (2010) “Wss1 Is a SUMO-Dependent Isopeptidase That Interacts Genetically with the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase.” Mol. Cell. Biol. 30: 3737 - 3748. Full Paper

Muromoto, R., et al. (2006). "Sumoylation of Daxx Regulates IFN-Induced Growth Suppression of B Lymphocytes and the Hormone Receptor-Mediated Transactivation." J. Immunol. 177(2): 1160-1170. Full Paper

Seyfried, N.T., et al. (2010) "Multiplex SILAC Analysis of a Cellular TDP-43 Proteinopathy Model Reveals Protein Inclusions Associated with SUMOylation and Diverse Polyubiquitin Chains." Mol. Cell. Proteomics. 9: 705 - 718. Full Paper

van Waardenburg, R. C. A. M., et al. (2006). "Distinct Functional Domains of Ubc9 Dictate Cell Survival and Resistance to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969. Full Paper

Xie, Y., et al. (2010) "SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor." Genes & Dev. 24: 893 - 903. Full Paper

Yang, K., et al. (2011) “Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.” Genes & Dev. 25: 1847 - 1858. Full Paper

Yurchenko, V., et al. (2006). "SUMO Modification of Human XRCC4 Regulates Its Localization and Function in DNA Double-Strand Break Repair." Mol. Cell. Biol. 26(5): 1786-1794. Full Paper

Zunino, R., et al.(2009) "Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis." J. Biol. Chem. 284: 17783-17795. Full Paper

Transcription Factors

Bish, R. A. and M. P. Myers (2007). "Werner Helicase-interacting Protein 1 Binds Poly-ubiquitin via Its Zinc Finger Domain." J. Biol. Chem. 282(32): 23184-23193. Full Paper

Burnett, B.G., et al. (2009) "Regulation of SMN Protein Stability." Mol. Cell. Biol. 29(5): 1107-1115. Full Paper

Chang, W., et al. (2003) "TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres." Genes & Dev. 17: 1328-1333. Full Paper

Daulny, A., et al. (2008) "Modulation of RNA polymerase II subunit composition by ubiquitylation." PNAS 105(50): 19649-19654. Full Paper

de Thonel, A., et al. (2010) “HSP27 controls GATA-1 protein level during erythroid cell differentiation.” Blood116: 85 - 96. Full Paper

Frampton, J., et al. (2006) "Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe." Mol. Biol. Cell 17(7): 2976-2985. Full Paper

Gurova K. V., et al. (2005) "Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors." PNAS 102(48): 17448-17453. Full Paper

Gurtan, A. M., et al. (2006) "The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly." J. Biol. Chem. 281(16): 10896-10905. Full Paper

Haracska, L., et al. (2006) "Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis." PNAS 103(17): 6477-6482. Full Paper

Havens, C. G., et al. (2006) "Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell. Biol. 26(12): 4701-4711. Full Paper

Hwang, X-S., et al. (2009) "Two proteolytic pathways regulate DNA repair by co-targeting the Mgt1 alkylguanine transferase." PNAS 106(7): 2142-2147. Full Paper

Jones, J.M., et al. (2003) "Autoubiquitylation of the V(D)J recombinase protein RAG1." PNAS 100(26): 15446-15451. Full Paper

Jung Y. and Lippard S.J. (2005) "RNA Polymerase II Blockage by Cisplatin-damaged DNA: Stability and poly-ubiquitylation of stalled polymerase." J. Biol. Chem.: 281-25001-25005. Full Paper

Jung, Y. and S. J. Lippard (2006). "RNA Polymerase II Blockage by Cisplatin-damaged DNA: Stability and poly-ubiquitylation of stalled polymerase." J. Biol. Chem. 281(3): 1361-1370. Full Paper

Kang, T.-H., et al. (2010) “Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein” Nucleic Acids Res. 10.1093/nar/gkq1318.* Full Paper

Karagianni, P., et al. (2008) "ICBP90, a Novel Methyl K9 H3 Binding Protein Linking Protein Ubiquitination with Heterochromatin Formation" Mol. Cell. Biol. 28: 705-17. Full Paper

Kerns, S. L., et al. (2007). "Geminin Prevents Re-replication during Xenopus Development." J. Biol. Chem. 282(8): 5514-5521. Full Paper

Kuznetsova, A.V., et al. (2003) "von Hippel-Lindau protein binds hyper-phosphorylated large subunit RNA polymerase II through a praline hydroxylation motif and targets it for ubiquitination." PNAS 100(5): 2706-2711. Full Paper

Lagarou, A., et al. (2008) "KDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing." Genes & Dev. 22(20): 2799-2810. Full Paper

Laine, A., I. et al. (2006). "Regulation of p53 Localization and Activity by Ubc13." Mol. Cell. Biol. 26(23): 8901-8913. Full Paper

Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol. 26(11): 4122-4133. Full Paper

Lotz C., et al. (2005) "Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple Myeloma-Reactive CTL." J. Immunol. 175(2): 1301-1309. Full Paper

Mersman, D.P., et al. (2009) "Poly-ubiquitination of the demethylase Jhd2 controls histone methylation and gene expression." Genes & Dev. 23: 951-962. Full Paper

Miyase S., et al. (2005) "Differential Regulation of Rad18 through Rad6-dependent mono- and poly-ubiquitination." J. Biol. Chem. 280(1): 515-524. Full Paper

Mo, P., et al. (2010) “MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3.” J. Biol. Chem. 285: 26908 - 26915. Full Paper

Ogawa S., et al. (2004) "A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation." PNAS 101(40): 14461-14466. Full Paper

Oh Y.K., et al. (2008) "Role of Activating Transcription Factor 3 on TAp73 Stability and Apoptosis in Paclitaxel-Treated Cervical Cancer Cells." Mol. Canc. Res. 6: 1232-1249. Full Paper

Pasillas, M., et al. (2011) “NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome.” Human Mutation, 32: 292-298 Full Paper

Pebernard, S., et al. (2008) "Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holo-complex in Genome Stability." Mol. Biol. Cell 19(10): 4099-4109. Full Paper

Pepbernard S., et al. (2008) "Ku80 removal from DNA through double strand break–induced ubiquitylation." J. Cell. Biol. 182(3):467-479. Full Paper

Pinato, S., et al. (2011) “UMI, a Novel RNF168 Ubiquitin Binding Domain Involved in the DNA Damage Signaling Pathway.” Molecular and Cellular Biology, 31: 118-126. Full Paper

Plafker, K.S., et al. (2010) “The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2.” J. Biol. Chem. 285: 23064 - 23074. Full Paper

Prager, K., et al. (2007) "A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3β-mediated Phosphorylation Regulates the Interaction with β-Catenin and Its Nuclear Signaling." J. Biol. Chem. 282(19): 14083-14093. Full Paper

Saugar, I., et al. (2011) “The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.” Nucleic Acids Res. 10.1093/nar/gkr738. Full Paper

Shao, G., et al. (2009) "MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks." Genes & Dev. 23(6): 740-754. Full Paper

Shim, M., et al. (2003). "Lithium stabilizes the CCAAT/Enhancer-binding protein α (C/EBPα) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibitor of proteasomal activity." Genes Cells 11(7): 731-744. Full Paper

Wang B., (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control." Genes & Dev.pan style="mso-spacerun:yes" 23(6): 729-739. Full Paper

Wang, H., et al. "Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6." J. Biol. Chem. 285: 13201 - 13210. Full Paper

Watanabe K., et al. (2004) "Rad18 guides polβ to replication stalling sites through physical interaction and PCNA mono-ubiquitination." EMBO J. 23(19): 3886-3896. Full Paper

Watanabe, K., et al. (2009) "RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1." Nucleic Acids Res. 37: 2176-2193. " Full Paper

Wei, W., et al. (2007). "Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPβ." Am. J. Physiol. Cell Physiol. 292(1): C216-226. Full Paper

Yan C., et al. (2005) "Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination." EMBO J. 24(13): 2425-2435. Full Paper

Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo/em> and enhances the activity of ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181. Full Paper

Yang J., et al. (2005) "Light Regulates COP1-Mediated Degradation of HFR1, a Transcription Factor Essential for Light Signaling in Arabidopsis." Plant Cell 17(3): 804-821. Full Paper

Yang, Y., et al. (2010) “E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF-induced JNK activation.” PNAS 107: 13444 - 13449. Full Paper

Yuasa, M. S., et al. (2006). "A human DNA polymerase-εcomplex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest." Genes Cells 11(7): 731-744. Full Paper

Zhang D. D., et al. (2005) "Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway." J. Biol. Chem. 280(34): 30091-30099. Full Paper

Ubiquitin Conjugating Enzymes

Apaja, P. M., et al. (2010) “Quality control for unfolded proteins at the plasma membrane.” J. Cell Biol. 191: 553–570. Full Paper

Bacik, J., et al. (2010) “Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME.” J. Biol. Chem. 285: 20273 - 20280. Full Paper

Bazirgan O.A and Hampton R.Y. 2008. "Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo." J. Biol. Chem.: 283(19):12797-810. Full Paper

Bocik, W., et al. (2011) “Mechanism of Polyubiquitin Chain Recognition by the Human Ubiquitin Conjugating Enzyme Ube2G2.” The Journal of Biological Chemistry, 286: 3981-3991. Full Paper

Bosanac, I., et al. (2011) “Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A.” Journal of Mol. Bio.: doi:10.1016/j.jmb.2011.03.011.* Full Paper

Chen L. and Madura K. (2005) "Increased Proteasome Activity, Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor Detected in Breast Cancer Tissue." Cancer Res. 65(13): 5599-5606. Full Paper

Chen, A., et al. (2011) “Enzyme E2 from Chinese White Shrimp Inhibits Replication of White Spot Syndrome Virus and Ubiquitinates Its RING Domain Proteins.” J. Virol. 85: 8069 - 8079. Full Paper

Chiang M-H., et al. (2008) "Ubiquitin-Conjugating Enzyme UBE2D2 Is Responsible for FBXW2 (F-Box and WD Repeat Domain Containing 2)-Mediated Human GCM1 (Glial Cell Missing Homolog 1) Ubiquitination and Degradation." Biol Reprod 79(5):914-920 Full Paper

Dammer, E., et al. (2011) “Polyubiquitin linkage profiles in three models of proteolytic stress suggest etiology of Alzheimer disease.” The Journal of Biological Chemistry: doi: 10.1074/jbc.M110.149633. Full Paper

David, Y., et al. (2010) “The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines.” J. Biol. Chem. 285: 8595 - 8604 Full Paper

Durfee L.A,. et al (2008) "The Basis for Selective E1-E2 Interactions in the ISG15 Conjugation System." J. Biol. Chem. 283(35):23895-23902 Full Paper

Gazdoiu S., et al. (2005) "Proximity-induced activation of human Cdc34 through heterologous dimerization." PNAS 102(42): 15053-15058. Full Paper

Kadara, H., et al. (2009) “Identification of Gene Signatures and Molecular Markers for Human Lung Cancer Prognosis using an In vitro Lung Carcinogenesis System.” Cancer Prevention Research 2: 702 - 711. Full Paper

Laine, A., et al. (2006) "Regulation of p53 Localization and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913. Full Paper

Li, W., et al. (2009) "Mechanistic insights into active site-associated poly-ubiquitination by the ubiquitin-conjugating enzyme Ube2g2." PNAS 106(10): 3722-3727. Full Paper

Li, Z., et al. (2008). "Cdc34p biquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein." J. Virol 82(14): 16911-6926. Full Paper

Liu, Q., et al. (2006). "Ubiquitin-Conjugating Enzyme 3 Delays Human Lens Epithelial Cells in Metaphase." Invest. Ophth. Vis. Sci. 47(4): 1302-1309. Full Paper

Longerich, S., et al. (2009) “FANCI Binds Branched DNA and Is Monoubiquitinated by UBE2T-FANCL.” J. Biol. Chem. 284: 23182 - 23186. Full Paper

Mitra, S., et al. (2011) “Role of GADD45a in Akt Phosphorylation and Ubiquitination Following Mechanical Stress-Induced Vascular Injury.” Am. J. Respir. Crit. Care Med. 10.1164/rccm.201103-0447OC. Full Paper

Oh K.-J., et al. (2004) "The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase." J. Virol. 78(10): 5338-5346. Full Paper

Oh, R. S., et al. (2006) "Human Homologs of Ubc6p Ubiquitin-conjugating Enzyme and Phosphorylation of HsUbc6e in Response to Endoplasmic Reticulum Stress." J. Biol. Chem. 281(30): 21480-21490. Full Paper

Patel, D. and McCance, D. J. (2010) “Compromised Spindle Assembly Checkpoint due to Altered Expression of Ubch10 and Cdc20 in Human Papillomavirus Type 16 E6- and E7-Expressing Keratinocytes.” J. Virol. 84: 10956-10964. Full Paper

Petroski, M. D., et al. (2007). "Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme." J. Biol. Chem. 282:29729-29737. Full Paper

Plafker S. M., et al. (2004) "Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import." J. Cell Biol. 167(4): 649-659. Full Paper

Sadowski, M. et al. (2010) "Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34."Mol. Cell. Biol. 30: 2316 - 2329. Full Paper

Stringer, D. and Piper, R. (2011) “A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT Ubiquitination.” JCB, 192: 229-242. Full Paper

Van Ree, J., et al. (2010) “Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.” J. Cell Biol. 188: 83 - 100. Full Paper

van Waardenburg, R. C. A. M., et al. (2006). "Distinct Functional Domains of Ubc9 Dictate Cell Survival and Resistance to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969. Full Paper

Vina-Vilaseca, A. and Sorkin, A. (2010) “Lysine 63-linked Polyubiquitination of the Dopamine Transporter Requires WW3 and WW4 Domains of Nedd4-2 and UBE2D Ubiquitin-conjugating Enzymes.” J. Biol. Chem. 285: 7645 - 7656. Full Paper

Walker A., et al. (2008) "UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator." J. Cell. Sci. 121: 2319-2326. Full Paper

Wang, X., et al. (2009) “Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.” J. Cell Biol. 187: 655 - 668. Full Paper

Wen, R., et al. (2008) "Arabidopsis UEV1D Promotes Lysine-63-Linked Poly-ubiquitination and is Involved in DNA Damage Response." Plant Cell 20: 213-27. Full Paper

Whitcomb, E.A., et al. (2009) "Novel Control of S Phase of the Cell Cycle by Ubiquitin-conjugating Enzyme H7." Mol. Biol. Cell 20(1): 1-9. Full Paper

Wickliffe, K., et al. (2011) “The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2.” Cell, 144: 769-781. Full Paper

Wu, T., et al. (2010) “UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex.” PNAS 107: 1355 - 1360. Full Paper

Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181.