Product References
* Published online ahead of print
Apoptosis / Cell Cycle
Arias E. E. and Walter J.C. (2005) "Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts." Genes & Dev. 19(1): 114-126.
Auld, C. A. and R. F. Morrison (2006). "Evidence for Cytosolic p27kip1 Ubiquitylation and Degradation during Adipocyte Hyperplasia." Obesity 14: 2136-2144.
Burstein E., et al. (2004) "A novel role for XIAP in copper homeostasis through regulation of MURR1." EMBO J. 23(1): 244-254.
Choi, E. et al. (2008) "Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex." J. Biol. Chem. 283(35): 23701-23710.
Dai, M.-S., D. et al. (2006). "Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism." J. Biol. Chem. 281(34): 24304-24313.
Eguchi, H., et al. (2003). "Helicobacter pylori increases proteasome-mediated degradation of p27kip1 in gastric epithelial cells." Canc. Res. 63: 4739-4746.
Germano, S., D. et al. (2006). "Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling." J. Biol. Chem. 281: 21710-21719.
Gottifredi V., et al. (2004) "Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block." J. Biol. Chem. 279(7): 5802-5810.
Gurova K. V., et al. (2005) "Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors." PNAS 102(48): 17448-17453.
Hata T., et al. (2005) "Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells." Mol. Canc. Ther. 4(10): 1585-1594.
Harmey, D., et al. (2009) “The Anaphase Promoting Complex Induces Substrate Degradation during Neuronal Differentiation.” J. Biol. Chem. 284(7): 4317-4323.
Havens, C. G., et al. (2006). "Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell. Biol. 26(12): 4701-4711
Hedhli, N., et al. (2008) “Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload.” Am. J. Physiol. Heart. Circ. Physiol. 295 (4): H1385-H1393.
Hong, K. U., et al. (2007). "Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis ." Mol. Cell. Biol. 27(10): 3667-3681.
Kamynina, E., et al. (2007). "Regulation of Proto-Oncogenic Dbl by Chaperone-Controlled, Ubiquitin-Mediated Degradation” Mol. Cell. Biol. 27(5): 1809-1822.
Koshikawa N. and Takenaga K. (2005) "Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1α/Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor." Can. Res. 65(24): 11622-11630.
Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537.
Lolkema M.P., et al. (2005) "Tumor Suppression by the von Hippel-Lindau Protein Requires Phosphorylation of the Acidic Domain." J. Biol. Chem. 280(23): 22205-22211.
Lovly C.M., et al. (2008) "Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379." Mol. Cell. Biol. 28(19): 5874-5885.
Liu, Y., et al. (2007). "Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate." Canc. Res. 67(6): 2685-2692
Maynard M. A., et al. (2005) "Human HIF-3α 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma." FASEB J 19(11): 1396-1406.
Mukai A., et al. (2008) “Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.” J.Cell. Sci. 121: 1325-33.
Parcellier, A., et al. (2003). "HSP27 is a ubiquitin-binding protein involved in I-κBα proteasomal degradation." Mol. Cell. Biol. 23(11):5790-5802
Pham, L.V., et al. (2003). "Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis." J. Immunol. 171:88-95
Samuel, T., et al. (2006). "Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases." J. Biol. Chem. 281(2): 1080-1090.
Schmidt A., et al. (2005) "Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity." Genes & Dev. 19(4): 502-513.
Shirogane T., et al. (2005) "SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Protein." J. Biol. Chem. 280(29): 26863-26872.
Song, S.J., et al. (2009) “Aurora A Regulates Pro-metaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity.” Cancer Res. 69(6): 2314-2323.
Su, L., et al. (2003) "p190RhoGAP is cell-cycle regulated and affect cytokinesis." J. Cell. Biol. 163(3): 571-582
Sun, L., et al. (2009) “JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.” PNAS 106: 10195-10200
Uchida C., et al. (2005) "Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation." EMBO J. 24(1): 160-169.
Watanabe N., et al.(2004) "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP." PNAS 101(13): 4419-4424.
Wei, W., et al.(2004) "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase promoting complex." Nature 428: 194-198.
Xu Q., et al. (2004) "Bortezomib rapidly suppresses ubiquitin thiolesterification to ubiquitin-conjugating enzymes and inhibits ubiquitination of histones and type I inositol 1,4,5-trisphosphate receptor." Mol. Cancer Ther. 3(10): 1263-1269.
Yan C., et al. (2005) "Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination." EMBO J. 24(13): 2425-2435.
Yang Q.-H. and Du C. (2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Zhu, F., et al. (2006). "COOH-Terminal Src Kinase-Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation." Cancer Res. 66(11): 5729-5736.
Cullins
Bibeau-Poirier, A., S.-P. Gravel, et al. (2006). "Involvement of the I{kappa}B Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation." J. Immunol. 177(8): 5059-5067.
*Christopher, B., et al. (2009) “The EBV Deubiquitinating Enzyme, BPLF1, Reduces EBV Ribonucleotide Reductase Activity.” J. Virol. JVI.02195-08v1
Furukawa, M. and Xiong Y. (2005) "BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase." Mol. Cell. Biol. 25(1): 162-171.
Gallegos J.R., et al. (2008) “SCF TrCP1 Activates and Ubiquitylates TAp63γ.” J. Biol. Chem. 283: 66-75.
Hernandez-Munoz I., et al. (2005) "From the Cover: Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase." PNAS 102(21): 7635-7640.
Hiramatsu, Y., K. Kitagawa, et al. (2006). "Degradation of Tob1 Mediated by SCFSkp2-Dependent Ubiquitination." Cancer Res. 66(17): 8477-8483.
Horn P. J., et al. (2005) "A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation." Genes & Dev. 19(14): 1705-1714.
Ji, P., et al. (2006). "Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27kip1." J. Biol. Chem. 281(33): 24058-24069.
Kim, A.Y., et al. (2008) “SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation.” J. Biol. Chem. 283(48): 33211-33220.
Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1." Mol. Cell. Biol. 26(4): 1235-1244.
Menon S., et al. (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.” BMC Biochem. 9:1
Ohh, M.., et al. (2002). "An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.” EMBO Reports 3(2): 177-182.
Pick, E., et al. (2007). "Mammalian DET1 Regulates Cul4A Activity and Forms Stable Complexes with E2 Ubiquitin-Conjugating Enzymes.” Mol. Cell. Biol. 27(13): 4708-4719.
Sakamoto, K.M., et al. (2003). "Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation.” Mol. Cell. Proteomics 2: 1350-1358.
Skaar, J. R., et al. (2007). "PARC and CUL7 Form Atypical Cullin RING Ligase Complexes.” Cancer Res. 67(5): 2006-2014.
Wang W., et al. (2004) "Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail." J. Biol. Chem. 279(49): 51362-51369.
Yamoah K., et al. (2008) "Molecular and Biochemical Characterization of the Skp2-Cks1 Binding Interface." PNAS 105(34):12230-12235.
Deconjugating Enzymes
Amsel A.D., et al. (2008) ‘Regulation of the pro-apoptotic factor Bax by Ku70-dependent deubiquitylation.’ PNAS 105: 5117-22.
Avvakumov, G. V., et al. (2006). "Amino-terminal dimerization, NRDP1 (FLRF) - rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin specific protease 8 (USP8/UBPY)." J. Biol. Chem.281(49):38061-38070.
Barretto N., et al. (2005) "The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity." J. Virol. 79(24): 15189-15198.
Bellare, P. et al. (2006). "Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p." RNA 12(2): 292-302.
Burnett, B. et al. (2003). "The polyglutamine neurodegenerative protein Ataxin-3 binds poly-ubiquitinated proteins and has ubiquitin protease activity." Hum. Mol. Genet. 12(23): 3195-3205.
Catic A., et al. (2007) "Screen for ISG15-cross-reactive Deubiquitinases." PLoS ONE 2(7): E769.
Chen, Z., Y. Wang, et al. (2007). "Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63." J. Virol. 81(11): 6007-6018.
Cohn, M.A., et al. (2009) "UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes." J. Biol. Chem. 284 (8): 5343-5351
Das, C., et al. (2006). "Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1." PNAS 103(12): 4675-4680.
Doss-Pepe, E.W., et al. (2003). "Ataxin-3 interactions with Rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis." Mol. Cell. Biol 23(18): 6469-6483.
Evans, P.C., et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival has de-ubiquitination activity." Biochem. J. 378: 727-734.
Faustrup, H., et al. (2009) "USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin." J. Cell Biol. 184(1):13-19.
Gallery, M., J. L. Blank, et al. (2007). "The JAMM motif of human deubiquitinase Poh1 is essential for cell viability." Mol. Cancer Ther. 6(1): 262-268.
Gredmark, S., et al. (2007). "The large tegument protein (ORFF) of the mouse γ herpes virus MHZ-68 encodes a functional Ubiquitin-specific protease, expressed and active in the course of infection." J. Virol.: 81:10300-10309.
Kabuta T., et al. (2008). "Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1." Hum. Mol. Genet. 17(10):1482-1496.
Kee, Y., et al. (2006). "The Ubp2 deubiquitinating enzyme modulates Rsp5-dependent K63-linked polyubiquitin conjugates in Saccharomyces cerevisiae." J. Biol. Chem. 286: 36724-36731.
Koulich, E., et al. (2008) ‘Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome.’ Mol. Biol. Cell 19: 1072-82.
Le Negrate, G., et al. (2008) ‘Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and Modulates Innate Immune Responses.’ J. Immunol. 180: 5045-56.
Lima, C.D. and Reverter, D. (2008) "Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7." J. Biol. Chem. 283 (46): 32045-32055.
Lindner H. A., et al. (2005) "The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus is a Deubiquitinating Enzyme." J. Virol. 79(24): 15199-15208.
Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol. 26(11): 4122-4133.
McCullough J., et al. (2004) "AMSH is an endosome-associated ubiquitin isopeptidase." J. Cell Biol. 166(4): 487-492.
* Misaghi. S, et al. (2009) "Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1." Mol. Cell. Biol. MCB.01517-08v1
Mizuno, E., et al. (2005) "Regulation of Epidermal Growth Factor Receptor Down-Regulation by UBPY-mediated Deubiquitination at Endosomes." Mol. Biol. Cell 16(11): 5163-5174.
Nakamura, M. N. Tanaka, et al. (2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes." Genes Cells 11(6): 593-606.
Nicholson, B., et al. (2008). "Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities." Prot. Sci. 17: 1035-1043.
Osaka, H., et al. (2003). "Ubiquitin carboxyl-terminal hydrolases L1 binds to and stabilizes monoubiquitin in neuron." Hum. Molec. Genet. 12: 1945-1958.
Pierre, S., et al. (2008) "Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) during Spinal Nociceptive Processing." Mol. Cell. Proteomics 7(12): 2475-2485.
Popp, M.W., et al. (2009) "Substrate Filtering by the Active Site Crossover Loop in UCHL3 Revealed by Sortagging and Gain-of-function Mutations." J. Biol. Chem. 284 (6): 3593-3602.
Ratia, K, et al. (2008). "A non-covalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication." PNAS 105 (42): 16119-16124
Row, P. E., H. Liu, et al. (2007). "The MIT domain of UBPY constitutes a CHMP binding and endosomal localisation signal required for efficient EGF receptor degradation." J. Biol. Chem.: 282:30929-30937.
Rytkonen, A., et al. (2007) "SseL, a Salmonella deubiquitinase required for macrophage killing and virulence4." PNAS 104(9): 3502-3507.
Sakurai, M., et al. (2006) "Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation." J. Cell Sci. 119(1): 162-171.
Shanks. J., et al. (2009) "Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages." Infect. Immun. 77 (4): 1636-1648.
Shenoy, S.K., et al. (2009) "b-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." PNAS 106: 6650-6655
Stanisic, V., et al (2009) "OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER)a and Affects ERa Transcriptional Activity. J. Biol. Chem. 284: 16135-16145
Takeyama, K., et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity." J. Biol. Chem. 278(24): 21930-21937.
Todi, S. V., et al. (2007). "Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity." J. Biol. Chem.: 282(40): 29348-29358.
Tzimas C, et al. (2006) "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Cell. Signal. 18(1):83-92.
Wang, J., et al. (2006). "High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus is a Competent Deubiquitinating Protease: Mutant Viruses Altered in its Active-Site Cysteine or Histidine are Viable." J. Virol. 80(12): 6003-6012.
Whitehurst, C.B., et al. (2009) "The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity." J. Virol. 83: 4345-4353
Winborn, B.J., et al. (2008) "The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits K63-linkages in mixed linkage ubiquitin chains." J. Biol. Chem. 283(39):26436-26443
Xu, S., et al. (2007). "Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase." J. Biol. Chem. 282(21): 15462-15470.
Ye, Z., et al. (2007) "Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination." Am. J. Pathol. 171: 882-892.
Yi, Y.-J., et al. (2007). "Ubiquitin C-Terminal Hydrolase-Activity Is Involved in Sperm Acrosomal Function and Anti-Polyspermy Defense During Porcine Fertilization." Biol. Reprod.77:780-793.
Zhou H., et al. (2005) "Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation." J. Exp. Med. 202(10): 1327-1332.
E3 Ligases
Abramovitch, R. B., et al. (2006). "Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity." PNAS 103(8): 2851-2856.
Balastik, M., et al. (2008) "Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration." PNAS 105 (33): 12016-12021.
Bartee E., et al. (2004) "Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins." J. Virol. 78(3): 1109-1120.
Bottomley M., et al. (2005) "NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1): Insights into Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Apeced) Disease." J. Biol. Chem. 280(12): 11505-11512.
Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear RING Domain Protein with Functional Connections to Chromatin Modification in Saccharomyces cerevisiae." Mol. Cell. Biol. 27(8): 2800-2811
Brooks, W.S., et al. (2008) "G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development." J. Biol. Chem. 283(32): 22304-22315.
Burnett, B. G. and Pittman R.N. (2005) "The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation." PNAS 102(12): 4330-4335.
Butler, M. P., et al. (2007). "Kinase active IRAKs promote polyubiquitination and degradation of the Pellino family: Direct evidence for Pellino proteins being E3 ubiquitin ligases." J. Biol. Chem. 282:29729-29737.
Bunce, M.W., et al. (2008) "Coordinated Activation of the Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of Phosphatidylinositol 5-Phosphate." J. Biol. Chem. 283: 8678-8686.
Canning, M., et al. (2004) "A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7." J. Biol. Chem. 279(37): 38160-38168.
Cohen, S., et al. (2009) "During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation." J. Cell Biol. 185: 1083-1095
Choi, D.W., et al. (2008) "Ubiquitination and Degradation of Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box Protein WSB-1." J. Biol. Chem. 283: 4682-4689.
Cooper, E.M., et al. (2009) "K63-specific deubuiquitination by two JAMM/MPN+ complexes:BRISC-associated Brcc-36 and proteasomal Poh1." EMBO J. 28(6) 621-631
Cooper E. M., et al. (2004) "Biochemical Analysis of Angelman Syndrome-associated Mutations in the E3 Ubiquitin Ligase E6-associated Protein." J. Biol. Chem. 279(39): 41208-41217.
Dasgupta A., et al. (2004) "Sir Antagonist 1 (San1) Is a Ubiquitin Ligase." J. Biol. Chem. 279(26): 26830-26838.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl. Physiol. 98(4): 1314-1321.
Doss-Pepe E. W., et al. (2005) "α-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains." J. Biol. Chem. 280(17): 16619-16624.
Dul, B. E. and N. C. Walworth (2007). "The Plant Homeodomain Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase Activity." J. Biol. Chem. 282(25): 18397-18406.
Espinosa, A., et al. (2006). "The Sjogren's Syndrome-Associated Auto-antigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death." J. Immunol. 176(10): 6277-6285.
Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am. J. Physiol.Reg.Integ. Comp. Physiol. 290(6): R1589-1597.
Fielitz, J., et al. (2007). "Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3." J. Clin. Inv. 117(9): 2486-2495.
Fotia, A.B., et al. (2005). "The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities." Intl. J. Biochem. Cell. Biol. 38(3): 472-479.
Fortier, J. M. and J. Kornbluth (2006). "NK Lytic-Associated Molecule, Involved in NK Cytotoxic Function, Is an E3 Ligase." J. Immunol. 176(11): 6454-6463.
French, M.E., et al. (2009) "Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site." J. Biol. Chem. 284: 12071-12079.
Fu, W., et al. (2009) "MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation." J. Biol. Chem. 284: 13987-14000.
Gentry M. S., et al. (2005) "From The Cover: Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin." PNAS 102(24): 8501-8506.
Goto, E., et al. (2003). "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." J. Biol. Chem. 278(17): 14657-14668.
Guan, B., et al. (2008) "Ubiquitination by TOPORS Regulates the Prostate Tumor Suppressor NKX3.1." J. Biol. Chem. 283: 4834-4840.
Habelhah H., et al. (2004) "Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB." EMBO J. 23(2): 322-332.
Hattori, T., et al. (2007) "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27kip1." Can. Res. 67: 10789-10795.
He, F., B. J. Fenner, et al. (2006). "White Spot Syndrome Virus Open Reading Frame 222 Encodes a Viral E3 Ligase and Mediates Degradation of a Host Tumor Suppressor via Ubiquitination." J. Virol. 80(8): 3884-3892.
Hrecka, K., M. Gierszewska, et al. (2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle." PNAS 104(28): 11778-11783.
Hristova, V.A., et al. (2009) "Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin." J. Biol. Chem. 284: 14978-14986.
Hu S. and Yang X. (2003). "Cellular inhibitor of apoptosis1 and 2 are ubiquitin ligase for the apoptosis inducer Smac/DIABLO." J. Biol. Chem. 278(12): 10055-10060.
Hua, Z. and T.-h. Kao (2006). "Identification and Characterization of Components of a Putative Petunia S-Locus F-Box-Containing E3 Ligase Complex Involved in S-RNase-Based Self-Incompatibility." Plant Cell 18(10): 2531-2553.
Jang I.-C., et al. (2005) "HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling." Genes & Dev. 19(5): 593-602.
Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels." Mol. Biol. Cell 18(8): 3105-3118.
Kalesnikoff, J., et al. (2007). "Roles of RabGEF1/Rabex-5 RI-dependent responses inεRI surface expression and Fcεdomains in regulating Fc mast cells." Blood 109(12): 5308-5317.
Kawahara, K., et al. (2008) α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution: ROLE " IN THE PATHOGENESIS OF PARKINSON DISEASE." J. Biol. Chem. 283: 6979-6987.
Kee Y., et al. (2005) "The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme." EMBO J. 24(13): 2414-2424.
Kim, H.C. and J.M. Huibregtse (2009) "Poly-ubiquitination by HECT E3s and the Determinants of Chain Type Specificity." Mol. Cell. Biol. 29: 3307-3318.
Kong, H. J., et al. (2007). "Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages." J. Immunol. 179(1): 26-30.
Koutelou, E., et al. (2008) "Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1." J. Biol. Chem. 283: 3846-53.
Kraft E., et al. (2005) "Genome Analysis and Functional Characterization of the E2 and RING-Type E3 Ligase Ubiquitination Enzymes of Arabidopsis." Plant Physiology 139(4): 1597-1611.
Koh, M.Y., et al. (2008) "Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1, Leading to Its Oxygen-Independent Degradation." Mol. Cell. Biol. 28 (23):7081-7095.
Kus B., et al. (2005) "A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5." J. Biol. Chem. 280(33): 29470-29478.
Laine, A., I., et al. (2006). "Regulation of p53 Localization and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.
Lamothe, B., et al. (2007). "Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation." J. Biol. Chem. 282(6):Determinant of I 4102-4112.
Lilley B. N. and Ploegh H.L (2005) "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." PNAS 102(40): 14296-14301.
Liu, L-J., et al. (2008) "COP1-Mediated Ubiquitination of CONSTANS Is Implicated in Cryptochrome Regulation of Flowering in Arabidopsis." Plant Cell. 20: 292-306.
Liu, Z., et al. (2009) "Human BRE1 Is an E3 Ubiquitin Ligase for Ebp1 Tumor Suppressor." Mol. Biol. Cell 20 (3): 757-768.
Lo, S.-C. and M. Hannink (2006). "PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex." J. Biol. Chem.: 281:37893-37903.
Lu, Z., et al. (2007). "Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction." J. Cell Biol. 177(6): 1077-1081
Lui, Q.Y., et al. (2008). "A novel brain-enriched E3 ubiquitin ligase RNF182 is up-regulated in the brains of Alzheimer’s patients and targets ATP6VOC for degradation." Molec. Degen. 3:4.
Luke-Glaser S., et al. (2007). "CIF-1, a Shared Subunit of the COP9/Signalosome and Eukaryotic Initiation Factor 3 Complexes, Regulates MEL-26 Levels in theCaenorhabditis elegans Embryo." Mol. Cell. Biol. 27(12): 4526-4540.
Maguire M., et al. (2008) "MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination." Canc. Res. 68: 3232-3242.
Malakhova O.A. and Zhang D-E. (2008) "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response." J. Biol. Chem. 283: 8783-8787.
Mansouri, M., et al. (2006). "Kaposi sarcoma herpes virus K5 removes CD31/PECAM from endothelial cells." Blood 108(6): 1932-1940.
Mao, X,. et al. (2009) "GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kB/RelA." Genes & Dev. 23: 849-861.
Marteijn J. A. F., et al. (2005) "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." Blood 106(13): 4114-4123.
Misaghi, S., et al. (2009) "Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1." Mol. Cell. Biol. 29: 2181-2192.
Miyauchi, Y., et al. (2008) "The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination." J. Biol. Chem. 283 (24):16622-16631.
Miller, S. L. H., et al. (2007). "Ubiquitin-interacting Motifs Inhibit Aggregation of PolyQ-expanded Huntingtin." J. Biol. Chem. 282(13): 10096-10103.
Morokuma, Y., et al. (2007). "MARCH-XI, a Novel Transmembrane Ubiquitin Ligase Implicated in Ubiquitin-dependent Protein Sorting in Developing Spermatids." J. Biol. Chem. 282(34): 24806-24815.
Mudgil Y., et al. (2004) "A Large Complement of the Predicted Arabidopsis ARM Repeat Proteins Are Members of the U-Box E3 Ubiquitin Ligase Family." Plant Physiology 134(1): 59-66.
Mulder, K. W., A. Inagaki, et al. (2007). "Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae." Genetics 176(1): 181-192.
*Nakao, R., et al. (2009) "Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading." Mol. Cell. Biol.: MCB.01347-08.
Nelson, R. F., et al. (2006). "A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control." J. Biol. Chem. 281(29): 20242-20251.
Nerenberg B. T. H., et al. (2005) "The Poxviral RING Protein p28 Is a Ubiquitin Ligase That Targets Ubiquitin to Viral Replication Factories." J. Virol. 79(1): 597-601.
Nishikawa, H., et al. (2009) "BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity." Canc. Res. 69 (1):111-119.
Nishikawa H., et al. (2004) "Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase." J. Biol. Chem. 279(6): 3916-3924.
Ohtsubo M., et al. (2008) "Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity." PNAS 105(30): 10396-10401.
Ogawa, M., et al. (2008) "Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase." Genes Cells 13: 397-409.
Olzmann, J.A., et al. (2007) "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6." J. Cell Biol. 178(6): 1025-1038.
Pan Y. and Chen J. et al. (2003). "MDM2 promotes ubiquitination and degradation of MDMX." Mol. Cell. Biol. 23(15): 5113-5121.
Peng H.-M., et al. (2004) "Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase." J. Biol. Chem. 279(51): 52970-52977.
Pierre S., et al. (2008) "Toponomics analysis of functional interactions of the ubiquitin ligase PAM during spinal nociceptive processing." Mol. Cell. Proteomics. 7(12)2475-2485
Quezada, C.M., et al. (2009) "A family of Salmonella virulence factors functions as a distinct class of auto-regulated E3 ubiquitin ligases." PNAS 106 (12): 4864-4869.
Rajendra R., et al. (2004) "Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53." J. Biol. Chem. 279(35): 36440-36444.
Sangadala, S., et al. (2006). "LIM Mineralization Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness via a Novel Interaction with Smurf1 Resulting in Decreased Ubiquitination of Smads." J. Biol. Chem. 281(25): 17212-17219.
Sargin, B., C. Choudhary, et al. (2007). "Flt3-dependent transformation by inactivating c-Cbl mutations in AML." Blood 110(3): 1004-1012.
Sasaki, M., et al. (2007). "MDM2 Binding Induces a Conformational Change in p53 That Is Opposed by Heat-shock Protein 90 and Precedes p53 Proteasomal Degradation." J. Biol. Chem. 282(19): 14626-14634.
Secombe J. and Parkhurst S.M. (2004) "Drosophila Topors Is a RING Finger-containing Protein That Functions as a Ubiquitin-protein Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor Protein." J. Biol. Chem. 279(17): 17126-17133.
Sekine K., et al. (2008). "Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation." J. Biol. Chem. 283(14): 8961-8968.
Sehat B, et al. (2008). "Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis" Canc. Res. 68: 5669-5677.
Shao, G., et al. (2009) "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks." Genes & Dev. 23: 740-754.
Sorkhy, M.A., et al. (2009) "The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4." J. Biol. Chem. 284(5): 2617-2627.
Starita L. M., et al. (2004) "BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number." Mol. Cell. Biol. 24(19): 8457-8466.
Stone S. L., et al. (2005) "Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis." Plant Physiology 137(1): 13-30.
Tatematsu, K., et al. (2008) "Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase Cβ." J. Biol. Chem. 283: 11575-85.
Torres, M.P., et al. (2009) "G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase." J. Biol. Chem. 284 (13): 8940-8950.
Tursun B., et al. (2005) "The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones." Genes & Dev. 19(19): 2307-2319.
Uchiki T., et al. (2009) "The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition." J. Biol. Chem. 284: 12622-12632.
Umebayashi K., et al. (2008) " Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation." Mol. Biol. Cell. 19(8): 3454-3462.
Varfolomeev E., et al. (2008) "c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α(TNFα)-induced NF-κB Activation." J. Biol. Chem. 283(36): 24295-24299.
Vega-Sanchez M.E., et al. (2008) "SPIN1, a K Homology Domain Protein Negatively Regulated and E3 Ubiquitin Ligase SPL11, Is Involved in Flowering Time Control in Rice." Plant Cell 20: 1456-1469.
Vichi A., et al. (2005) "E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1)" PNAS 102(6): 1945-1950.
Wada K. And Kamitani T. (2006) "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself." Biochem. Biophys. Res. Comm. 342(1): 253-258.
Wang, B., et al. (2009) "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control." Genes & Dev. 23: 729-739.
Wang, X., et al. (2007). "Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3." J. Cell Biol. 177(4): 613-624.
Wang, X., et al. (2006). "The Viral E3 Ubiquitin Ligase mK3 Uses the Derlin/p97 Endoplasmic Reticulum-associated Degradation Pathway to Mediate Down-regulation of Major Histocompatibility Complex Class I Proteins." J. Biol. Chem. 281(13): 8636-8644.
Wang Z., et al. (2005) "RING-H2 Protein WSSV249 from White Spot Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme, PvUbc, for Viral Pathogenesis." J. Virol. 79(14): 8764-8772.
Wawrzynow, B., et al. (2009) "A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity." J. Biol. Chem. 284: 11517-11530.
Wu, W., H. Nishikawa, et al. (2007). "BRCA1 Ubiquitinates RPB8 in Response to DNA Damage." Cancer Res. 67(3): 951-958.
Worby, C.A., et al. (2008) "Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG)". J. Biol. Chem. 283: 4069-76.
Yamada, M., J. Ohnishi, et al. (2006). "NARF, an emo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)." J. Biol. Chem. 281(30): 20749-20760.
Yamauchi, K., et al. (2008). "Ubiquitination of E3 ligase TRIM5α and its potential role." FEBS J. 275(7): 1540-1555.
Yao D., et al. (2004) "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." PNAS 101(29): 10810-10814.
Yogosawa S., et al.. (2005) "Ubiquitylation and Degradation of Serum-inducible Kinase by hVPS18, a RING-H2 Type Ubiquitin Ligase." J. Biol. Chem. 280(50): 41619-41627.
Yurchenko, V., et al. (2003). "The RAG1 N-terminal domain is an E3 ubiquitin ligase." Genes and Dev. 17(5): 581-585.
Zhang D. D., et al. (2003) "Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress." Mol. Cell. Biol. 23(22): 8137-8151.
Zhang D. D., et al. (2004) "Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex." Mol. Cell. Biol. 24(24): 10941-10953.
Zhang Y., et al. (2005) "Recognition and Ubiquitination of Salmonella Type III Effector SopA by a Ubiquitin E3 Ligase, HsRMA1." J. Biol. Chem. 280(46): 38682-38688.
Zhao H., et al. (2005) "A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation." J. Immunol. 174(9): 5288-5297.
Zhao, Y., et al. (2007). "Tumor Necrosis Factor Receptor 2 Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination and Terminates Mitogen-activated Protein Kinase Signaling." J. Biol. Chem. 282(11): 7777-7782.
ER Trafficking / receptors / signaling
Anderson, G.R., et al. (2007). " Expression and Localization of RGS9-2/Gb5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases ." J. Neurosci. 27(51): 14117-14127.
Almeida, C. G., et al. (2006). "β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System." J. Neurosci. 26(16): 4277-4288.
Barriere, H., et al. (2007). "Plasticity of Poly-Ubiquitin Recognition as Lysosomal Targeting Signals by the Endosomal Sorting Machinery." Mol. Biol. Cell. 18(10) :3952-3965.
Bergeron, A., et al. (2006). "Involvement of Endoplasmic Reticulum Stress in Hereditary Tyrosinemia Type I." J. Biol. Chem. 281(9): 5329-5334.
Chen, Y., et al. (2006). "Proteasome-dependent down-regulation of activated Stat5A in the nucleus." Blood 108(2): 566-574.
Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3) Mediates Ubiquitination and Degradation of Tumor Necrosis Factor Receptor II." Mol. Cell. Biol. 25(11): 4716-4726.
Conze, D.B., et al. (2008) “Lys63-Linked Poly-ubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation.” Mol. Cell. Biol. 28: 3538-47.
Cordier, F., et al. (2009) “The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain.” J. Biol. Chem. 284(5): 2902-2907.
Coulombe, P., et al. (2003) “Rapid turnover of extracellular signal-regulated Kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.” Mol. Cell. Biol. 23: 4542-4558.
Esposito, K., et al. (2006). "Rosiglitazone Cools Down Inflammation in the Metabolic Syndrome." Arterioscler. Thromb. Vasc. Biol. 26(6): 1413-1414.
Floyd, Z. E., et al. (2006). "Degradation of STAT5 Proteins in 3T3-L1 Adipocytes is induced by TNFα and cycloheximide in a manner independent of STAT5A activation." Am J Physiol Endocrinol Metab: 292(2):E461-8.
Forbes, A., et al. (2007). "The tetraspan protein EMP2 regulates expression of caveolin-1." J. Biol. Chem.: 282(36): 26542-26551.
Fotia A. B., et al. (2004) "Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2." J. Biol. Chem. 279(28): 28930-28935.
Fukuda, H., et al. (2006). "MARCH-III Is a Novel Component of Endosomes with Properties Similar to Those of MARCH-II." J. Biochem. (Tokyo) 139(1): 137-145.
Habelhah H., et al. (2004) "Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB." EMBO J. 23(2): 322-332.
Hatao, F., et al. (2004) "Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein." J. Leukoc. Biol. 76(4): 904-908.
Jang, I.-C., et al. (2007). "Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling." Genes & Dev. 21(16): 2100-2111.
Jalonen U, et al. (2008) "Compounds That Increase or Mimic Cyclic Adenosine Monophosphate Enhance Tristetraprolin Degradation in Lipopolysaccharide-Treated Murine J774 Macrophages." J. Pharm. Exp. Ther. 326: 514-522.
Kaneko-Oshikawa C., et al. (2005) "Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System." Mol. Cell. Biol. 25(24): 10953-10964.
Kim, S. T., et al. (2006). "Exogenous Free Ubiquitin Enhances Lily Pollen Tube Adhesion to an in Vitro Stylar Matrix and May Facilitate Endocytosis of SCA (Stigma/stylar Cysteine-rich Adhesin)." Plant Physiology: 142: 984-992.
Kim D. W., et al. (2005) "The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes." PNAS 102(39): 14046-14051.
Kostova, Z., et al. (2009) “A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.” J. Cell Sci. 122: 1374-1381.
Kowanetz K., et al. (2004) "Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases." J. Biol. Chem. 279(31): 32786-32795.
Lee T. H., et al. (2004) "The Kinase Activity of Rip1 Is Not Required for Tumor Necrosis Factor-α-induced IκB Kinase or p38 MAP Kinase Activation or for the Ubiquitination of Rip1 by Traf2." J. Biol. Chem. 279(32): 33185-33191.
Lilley B. N. and Ploegh H.L. (2005) "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." PNAS 102(40): 14296-14301.
Lo, S.-C. and M. Hannink (2006). "CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1." Mol. Cell. Biol. 26(4): 1235-1244.
Mansouri, M., et al. (2006). "Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells." Blood 108(6): 1932-1940.
Marfella, R., et al. (2006). "Increased Activity of the Ubiquitin-Proteasome System in Patients With Symptomatic Carotid Disease Is Associated With Enhanced Inflammation and May Destabilize the Atherosclerotic Plaque: Effects of Rosiglitazone Treatment." J. Am. Coll. Cardiol. 47(12): 2444-2455.
Marfella, R., et al. (2006). "The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment." Diabetes 55(3): 622-632.
Medina E. A., et al. (2005) "Tumor Necrosis Factor-α Decreases Akt Protein Levels in 3T3-L1 Adipocytes via the Caspase-Dependent Ubiquitination of Akt." Endocrinology 146(6): 2726-2735.
Mizuno, E., et al. (2003) “STAM proteins bind uibuiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.” Mol. Cell. Biol. 14(9): 3675-3689.
Nelson, R. F., et al. (2006). "A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control." J. Biol. Chem. 281(29): 20242-20251.
Ogawa S., et al. (2004) "A nuclear receptor co-repressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation." PNAS 101(40): 14461-14466.
Oved, S., Y. Mosesson, et al. (2006). "Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases." J. Biol. Chem. 281(31): 21640-21651.
Shah, O. J. and T. Hunter (2006). "Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis." Mol. Cell. Biol. 26(17): 6425-6434.
Song B.-L. and DeBose-Boyd R.A. (2004) "Ubiquitination of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Permeabilized Cells Mediated by Cytosolic E1 and a Putative Membrane-bound Ubiquitin Ligase." J. Biol. Chem. 279(27): 28798-28806.
Song, B.-L. and R. A. DeBose-Boyd (2006). "Insig-dependent Ubiquitination and Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Stimulated by δ- and γ-Tocotrienols." J. Biol. Chem. 281(35): 25054-25061.
Sun, Z., et al. (2007). "Keap1 Controls Post-Induction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2." Mol. Cell. Biol.: 27(18):6334-6349.
Wang H., et al. (2004) "Both the PPPY and PTAP Motifs Are Involved in Human T-Cell Leukemia Virus Type 1 Particle Release." J. Virol. 78(3): 1503-1512.
Zvonic S., et al. (2005) "Cross-talk among gp130 Cytokines in Adipocytes." J. Biol. Chem. 280(40): 33856-33863.
Proteasome Degradation
Adachi K., et al. (2004) "Ubiquitylation of Nascent Globin Chains in a Cell-free System." J. Biol. Chem. 279(40): 41767-41774.
Archer C.T., et al. (2008) "Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome." J. Biol. Chem. 283(31): 21789-21798.
Alroy I., et al. (2005) "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production." PNAS 102(5): 1478-1483.
Baldin, V., et al. (2008) ‘A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking.’ Mol. Biol. Cell 19: 1706-16.
Bianchi, G., et al. (2009) "The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition." Blood 113: 3040-3049.
*Bruce, S.R., et al (2009) "Respiratory Syncytial Virus (RSV) Infection Alters Surfactant Protein-A (SP-A) Expression in Human Pulmonary Epithelial Cells by Reducing Translation Efficiency." Am J Physiol Lung Cell Mol Physiol: 90507.2008.
Burnett, B.G., et al. (2009) "Regulation of SMN Protein Stability." Mol. Cell. Biol. 29: 1107-1115.
Burns, K.E., et al. (2009) "Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein." J. Biol. Chem. 284(5): 3069-3075.
Chen L. and Madura K. (2005) "Increased Proteasome Activity, Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor Detected in Breast Cancer Tissue." Cancer Res. 65(13): 5599-5606.
Chu, I., et al. (2007). "Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer." J. Clin. Invest. 117(8): 2205-2215.
Chuang S.-M., et al. (2005) "Proteasome-Mediated Degradation of Cotranslationally Damaged Proteins Involves Translation Elongation Factor 1A." Mol. Cell. Biol. 25(1): 403-413.
Chung A. S., et al. (2005) "Ankyrin Repeat and SOCS Box 3 (ASB3) Mediates Ubiquitination and Degradation of Tumor Necrosis Factor Receptor II." Mol. Cell. Biol. 25(11): 4716-4726.
Demo, S. D., et al. (2007). "Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome." Cancer Res. 67(13): 6383-6391.
Depre, C., Q. Wang, et al. (2006). "Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy." Circulation 114(17): 1821-1828.
DeRuisseau K. C., et al. (2005) "Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm." J. Appl .Physiol .98(4): 1314-1321.
Dominy, J.E., et al. (2006). "Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat." Biochem. J. 394: 267-273.
*Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Fruh K, Moses AV. (2009) "Vpu Directs the Degradation of the HIV Restriction Factor BST-2/tetherin via a bTrCP-dependent Mechanism." J. Virol.: JVI.00242-09.
Drews, O., et al. (2007). "Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities." Mol. Cell. Proteomics. 6(11):2021-2031
Dudek E. J., et al. (2005) "Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases." FASEB J (12): 1707-9
Fareed, M. U., et al. (2006). "Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression." Am J Physiol Reg. Integ. Comp. Physiol. 290(6): R1589-1597.
Ferdous, A., et al. (2007). "The role of the proteasomal ATPases and activator mono-ubiquitylation in regulating Gal4 binding to promoters." Genes & Dev. 21(1): 112-123.
Fernandez, A.F., et al. (2008) " Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8." J. Biol. Chem. 283(30): 20745-20753.
Floyd, Z. E., et al. (2007). "Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-α and cycloheximide in a manner independent of STAT5A activation." Am J Physiol Endocrinol Metab 292(2): E461-4
Gallagher, M. J., et al. (2007). "The GABAA receptor α1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation." PNAS 104(32): 12999-13004.
Garza, R.M., et al. (2009) "In Vitro Analysis of Hrd1p-mediated Retrotranslocation of its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase." J. Biol. Chem. 284: 14710-14722.
Ghaboosi, N. and R. J. Deshaies (2007). "A Conditional Yeast E1 Mutant Blocks the Ubiquitin-Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome." Mol. Biol. Cell 18(5): 1953-1963.
Gho, A.M., et al. (2008). "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins." BMC Biochem. 9:4.
Guo W., et al. (2004) "Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation." Invest. Ophthalmol. Vis. Sci. 45(4): 1194-1201.
Hedhli, N., et al. (2008) ‘Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.’ Cardiovasc. Res. 77: 497-505.
Heuzé, M.L., et al. (2008) "ASB2 targets filamins A and B to proteasomal degradation." Blood 112(13): 5130-5140.
Kavazis, A. N., et al. (2007). "Diaphragmatic proteasome function is maintained in the aging Fisher 344 rat." Exp Physiol: 92(5):895-901.
Kim, H.T.., et al. (2009) "S5a promotes protein degradation by blocking synthesis of non-degradable forked ubiquitin chains." EMBO J. 28: 1867-1877.
Kisselev, A. F., et al. (2006). "Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate." J. Biol. Chem. 281(13): 8582-8590.
Koodathingal, P., et al. (2009) "ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins." J. Biol. Chem. 284: 18674-18684.
Liang M., et al. (2004) "Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCFSkp2." Mol. Cell. Biol. 24(17): 7524-7537.
Lin, G., et al. (2008) "Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates." J. Biol. Chem. 283(49): 34423-34431.
Liu, J., et al. (2008) "A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome." Am. J. Physiol. Heart.Circ. Physiol. 295(6): H2541-H2550.
Marfella, R., et al. (2007). "Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin-Proteasome Activity." Hypertension 49(4): 784-791.
Marfella, R., et al. (2008) ‘Proteasome Activity as a Target of Hormone Replacement Therapy-Dependent Plaque Stabilization in Postmenopausal Women.’ Hypertension 51: 1135-41.
Marteijn, J. A. F., et al. (2006). "Diminished proteasomal degradation results in accumulation of Gfi1 protein levels in monocytes." Blood: 109: 100-108
McClung J.M., et al. (2008). "Redox regulation of diaphragm proteolysis during mechanical ventilation." Am. J. Physiol. Regul. Integ. Comp. Physiol. 294: R1608-1617.
Mehle A., et al. (2004) "Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway." J. Biol. Chem. 279(9): 7792-7798.
*Middeldorp J., et al. (2009) "Intermediate filament transcription in astrocytes is repressed by proteasome inhibition." FASEB J: fj.08-127696.
Okamura, T., et al. (2003) "Abnormally high expression of proteasome activator-γ in thyroid neoplasm." Clin. Endocrin. Metab. 88(3): 31374031383.
Reis, J., et al. (2008) "A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model." Innate Immunity 14(5): 319-329.
Reuter C. J. and Maupin-Furlow J.A. (2004) "Analysis of Proteasome-Dependent Proteolysis in Haloferax volcanii Cells, Using Short-Lived Green Fluorescent Proteins." Appl. Envir. Microbiol. 70(12): 7530-7538.
Rousseau, E., et al. (2009) "Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones." J. Biol. Chem. 284(3): 1917-1929.
Shang F., et al. (2005) "Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation." J. Biol. Chem. 280(21): 20365-20374.
Shen, H-W., et al. (2009) "Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats." J. Neurosci. 29: 28762884.
Smith, I. J. and S. L. Dodd (2007). "Muscle: Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle." Exp Physiol 92(3): 561-573.
Suzuki N., et al. (2004) "Proteasomal Degradation of the Nuclear Targeting Growth Factor Midkine." J. Biol. Chem. 279(17): 17785-17791.
Wang, Z.Q., et al. (2009) "Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys." Diabetes 58: 1488-1498.
Wei, W., et al. (2006). "Treatment of cultured myotubes with the proteasome inhibitor β-lactone increase expression of the transcription factor C/EBPβ." Am J Physiol Cell Physiol: 292:C216-C226.
Wherry, E. J., et al. (2006). "Re-evaluating the Generation of a "Proteasome-Independent" MHC Class I-Restricted CD8 T Cell Epitope." J. Immunol. 176(4): 2249-2261.
Willeumier, K., et al. (2006). "Proteasome Inhibition Triggers Activity-Dependent Increase in the Size of the Recycling Vesicle Pool in Cultured Hippocampal Neurons." J. Neurosci. 26(44): 11333-11341.
Williamson, M. J., et al. (2006). "Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib." Mol. Cancer Ther. 5(12): 3052-3061.
Yang, Q.-H. and Du C.(2004) "Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells." J. Biol. Chem. 279(17): 16963-16970.
Yang Z., et al. (2008) Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication. J. Virol. 82: 3590-603
Yimlamai T., et al. (2005) "Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway." J Appl Physiol 99(1): 71-80.
Yamano T., et al. (2008) "α-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation: UNDERSTANDING THE CYTOTOXICITY OF PROTEIN PROTOFIBRILS IN NEURODEGENERATIVE DISEASE PATHOGENESIS." J. Biol. Chem. 283(29): 20288-20298.
Zang N-Y., et al. (2008) "Proteasomal Degradation of the Nuclear Targeting Growth Factor Midkine." J. Biol. Chem. 279(17): 17785-17791.
SUMO
Benson, M. D., et al. (2007). "SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5." PNAS 104(6): 1805-1810.
Chou, C.-C., et al. (2007). "SUMO modification regulates the DNA-binding activity of GCMa." J. Biol. Chem.: 282(37): 27239-27249.
Dawlaly, M.M., et al. (2008) "Resolution of Sister Centromeres requires RanBP2-mediated SUMOylation of Topoisomerase IIα." Cell 133: 103-115.
Kagey M. H., et al. (2005) "Multiple activities contribute to Pc2 E3 function." EMBO J. 24(1): 108-119.
Lois L. M. and Lima C. D. (2005) "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1." EMBO J. 24(3): 439-451.
MacPherson, M.J., et al. (2009) "The CTCF Insulator Protein Is Post-translationally Modified by SUMO." Mol. Cell. Biol. 29(3): 714-725.
Muromoto, R., et al. (2006). "Sumoylation of Daxx Regulates IFN-Induced Growth Suppression of B Lymphocytes and the Hormone Receptor-Mediated Transactivation." J. Immunol. 177(2): 1160-1170.
van Waardenburg, R. C. A. M., et al. (2006). "Distinct Functional Domains of Ubc9 Dictate Cell Survival and Resistance to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969.
Yurchenko, V., et al. (2006). "SUMO Modification of Human XRCC4 Regulates Its Localization and Function in DNA Double-Strand Break Repair." Mol. Cell. Biol. 26(5): 1786-1794.
Zunino, R., et al.(2009) "Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis." J. Biol. Chem. 284: 17783-17795.
Transcription Factors
Bish, R. A. and M. P. Myers (2007). "Werner Helicase-interacting Protein 1 Binds Poly-ubiquitin via Its Zinc Finger Domain." J. Biol. Chem. 282(32): 23184-23193.
Burnett, B.G., et al. (2009) "Regulation of SMN Protein Stability." Mol. Cell. Biol. 29(5): 1107-1115.
Chang, W., et al. (2003) "TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres." Genes & Dev. 17: 1328-1333.
Daulny, A., et al. (2008) "Modulation of RNA polymerase II subunit composition by ubiquitylation." PNAS 105(50): 19649-19654.
Frampton, J., et al. (2006) "Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe." Mol. Biol. Cell 17(7): 2976-2985.
Gurova K. V., et al. (2005) "Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors." PNAS 102(48): 17448-17453.
Gurtan, A. M., et al. (2006) "The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly." J. Biol. Chem. 281(16): 10896-10905.
Haracska, L., et al. (2006) "Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis." PNAS 103(17): 6477-6482.
Havens, C. G., et al. (2006) "Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species." Mol. Cell. Biol. 26(12): 4701-4711.
Hwang, X-S., et al. (2009) "Two proteolytic pathways regulate DNA repair by co-targeting the Mgt1 alkylguanine transferase." PNAS 106(7): 2142-2147.
Jones, J.M., et al. (2003) "Autoubiquitylation of the V(D)J recombinase protein RAG1." PNAS 100(26): 15446-15451.
Jung, Y. and S. J. Lippard (2006). "RNA Polymerase II Blockage by Cisplatin-damaged DNA: Stability and poly-ubiquitylation of stalled polymerase." J. Biol. Chem. 281(3): 1361-1370.
Jung Y. and Lippard S.J. (2005) "RNA Polymerase II Blockage by Cisplatin-damaged DNA: Stability and poly-ubiquitylation of stalled polymerase." J. Biol. Chem.: 281-25001-25005.
Karagianni, P., et al. (2008) "ICBP90, a Novel Methyl K9 H3 Binding Protein Linking Protein Ubiquitination with Heterochromatin Formation" Mol. Cell. Biol. 28: 705-17.
Kerns, S. L., et al. (2007). "Geminin Prevents Re-replication during Xenopus Development." J. Biol. Chem. 282(8): 5514-5521.
Kuznetsova, A.V., et al. (2003) "von Hippel-Lindau protein binds hyper-phosphorylated large subunit RNA polymerase II through a praline hydroxylation motif and targets it for ubiquitination." PNAS 100(5): 2706-2711.
Lagarou, A., et al. (2008) "KDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing." Genes & Dev. 22(20): 2799-2810.
Laine, A., I. et al. (2006). "Regulation of p53 Localization and Activity by Ubc13." Mol. Cell. Biol. 26(23): 8901-8913.
Lis, E. T. and F. E. Romesberg (2006). "Role of Doa1 in the Saccharomyces cerevisiae DNA Damage Response." Mol. Cell. Biol. 26(11): 4122-4133.
Lotz C., et al. (2005) "Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple Myeloma-Reactive CTL." J. Immunol. 175(2): 1301-1309.
Mersman, D.P., et al. (2009) "Poly-ubiquitination of the demethylase Jhd2 controls histone methylation and gene expression." Genes & Dev. 23: 951-962.
Miyase S., et al. (2005) "Differential Regulation of Rad18 through Rad6-dependent mono- and poly-ubiquitination." J. Biol. Chem. 280(1): 515-524.
Pebernard, S., et al. (2008) "Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holo-complex in Genome Stability." Mol. Biol. Cell 19(10): 4099-4109.
Pepbernard S., et al. (2008) "Ku80 removal from DNA through double strand break–induced ubiquitylation." J. Cell. Biol. 182(3):467-479.
Prager, K., et al. (2007) "A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3β-mediated Phosphorylation Regulates the Interaction with β-Catenin and Its Nuclear Signaling." J. Biol. Chem. 282(19): 14083-14093.
Ogawa S., et al. (2004) "A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation." PNAS 101(40): 14461-14466.
Oh Y.K., et al. (2008) "Role of Activating Transcription Factor 3 on TAp73 Stability and Apoptosis in Paclitaxel-Treated Cervical Cancer Cells." Mol. Canc. Res. 6: 1232-1249.
Shao, G., et al. (2009) "MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks." Genes & Dev. 23(6): 740-754.
Shim, M., et al. (2003). "Lithium stabilizes the CCAAT/Enhancer-binding protein α (C/EBPα) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibitor of proteasomal activity." Genes Cells 11(7): 731-744.
Wang B., (2009) NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control." Genes & Dev.pan style="mso-spacerun:yes" 23(6): 729-739.
Watanabe, K., et al. (2009) "RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1." Nucleic Acids Res. 37: 2176-2193. "
Watanabe K., et al. (2004) "Rad18 guides polβ to replication stalling sites through physical interaction and PCNA mono-ubiquitination." EMBO J. 23(19): 3886-3896.
Wei, W., et al. (2007). "Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPβ." Am. J. Physiol. Cell Physiol. 292(1): C216-226.
Yan C., et al. (2005) "Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination." EMBO J. 24(13): 2425-2435.
Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo/em> and enhances the activity of ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181.
Yang J., et al. (2005) "Light Regulates COP1-Mediated Degradation of HFR1, a Transcription Factor Essential for Light Signaling in Arabidopsis." Plant Cell 17(3): 804-821.
Yuasa, M. S., et al. (2006). "A human DNA polymerase-εcomplex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest." Genes Cells 11(7): 731-744.
Zhang D. D., et al. (2005) "Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway." J. Biol. Chem. 280(34): 30091-30099.
Ubiquitin Conjugating Enzymes
Bazirgan O.A and Hampton R.Y. 2008. "Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo." J. Biol. Chem.: 283(19):12797-810.
Chen L. and Madura K. (2005) "Increased Proteasome Activity, Ubiquitin-Conjugating Enzymes, and eEF1A Translation Factor Detected in Breast Cancer Tissue." Cancer Res. 65(13): 5599-5606.
Chiang M-H., et al. (2008) "Ubiquitin-Conjugating Enzyme UBE2D2 Is Responsible for FBXW2 (F-Box and WD Repeat Domain Containing 2)-Mediated Human GCM1 (Glial Cell Missing Homolog 1) Ubiquitination and Degradation." Biol Reprod 79(5):914-920
Durfee L.A,. et al (2008) "The Basis for Selective E1-E2 Interactions in the ISG15 Conjugation System." J. Biol. Chem. 283(35):23895-23902
Gazdoiu S., et al. (2005) "Proximity-induced activation of human Cdc34 through heterologous dimerization." PNAS 102(42): 15053-15058.
Laine, A., et al. (2006) "Regulation of p53 Localization and Activity by Ubc13 " Mol. Cell. Biol. 26(23): 8901-8913.
Li, W., et al. (2009) "Mechanistic insights into active site-associated poly-ubiquitination by the ubiquitin-conjugating enzyme Ube2g2." PNAS 106(10): 3722-3727.
Li, Z., et al. (2008). "Cdc34p biquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein." J. Virol 82(14): 16911-6926.
Liu, Q., et al. (2006). "Ubiquitin-Conjugating Enzyme 3 Delays Human Lens Epithelial Cells in Metaphase." Invest. Ophth. Vis. Sci. 47(4): 1302-1309.
Oh K.-J., et al. (2004) "The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase." J. Virol. 78(10): 5338-5346.
Oh, R. S., et al. (2006) "Human Homologs of Ubc6p Ubiquitin-conjugating Enzyme and Phosphorylation of HsUbc6e in Response to Endoplasmic Reticulum Stress." J. Biol. Chem. 281(30): 21480-21490.
Plafker S. M., et al. (2004) "Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import." J. Cell Biol. 167(4): 649-659.
Petroski, M. D., et al. (2007). "Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme." J. Biol. Chem. 282:29729-29737.
van Waardenburg, R. C. A. M., et al. (2006). "Distinct Functional Domains of Ubc9 Dictate Cell Survival and Resistance to Genotoxic Stress." Mol. Cell. Biol. 26(13): 4958-4969.
Walker A., et al. (2008) "UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator." J. Cell. Sci. 121: 2319-2326.
Wen, R., et al. (2008) "Arabidopsis UEV1D Promotes Lysine-63-Linked Poly-ubiquitination and is Involved in DNA Damage Response." Plant Cell 20: 213-27.
Whitcomb, E.A., et al. (2009) "Novel Control of S Phase of the Cell Cycle by Ubiquitin-conjugating Enzyme H7." Mol. Biol. Cell 20(1): 1-9.
Yanagawa Y., et al. (2004) "Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes." Genes & Dev. 18(17): 2172-2181.
Assorted
Ausseil, F., et al. (2007). "High-Throughput Bioluminescence Screening of Ubiquitin-Proteasome Pathway Inhibitors from Chemical and Natural Sources." J. Biomol. Screen. 12(1): 106-116.
Esposito, K., et al. (2008) "Rosiglitazone cools down Inflammation in the Metabolic Syndrome." Arterioscler. Thromb. Vasc. Biol. 26: 1413-1414.
Graham, R., et al. (2008) "Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein." J. Gen. Virol. 81: 1913-1925.
Griebenow, M, et al. (2007) "Ubiquitin reduces contusion volume after controlled cortical impact injury in rats." J. Neurotrauma 24(9): 1529-1535.
Guo, W., et al. (2006). "Ubiquitin-Proteasome Pathway Function Is Required for Lens Cell Proliferation and Differentiation." Invest. Ophth. Vis. Sci. 47(6): 2569-2575.
Lin, JH-C., et al. (2008) "A Central Role of Connexin 43 in Hypoxic Preconditioning." J. Neurosci. 28: 681-95.
Link, M. A., et al. (2007). "Cathepsin B Mediates Cleavage of Herpes Simplex Virus Type 1 Origin Binding Protein (OBP) To Yield OBPC-1, and Cleavage Is Dependent upon Viral DNA Replication."J. Virol. 81(17): 9175-9182
Mansouri, M., et al. (2008) "Remodeling of endothelial adherens junctions by Kaposi's sarcoma herpesvirus." J. Virol. 82(19):9615-9628
Marfella, R., et al. (2008) "Effects of Ubiquitin-Proteasome System Deregulation on the Vascular Senescence and Atherosclerosis Process in Elderly Patients." J. Gerontol. A Biol. Sci. Med. Sci. 63: 200-3.
McClung, J.M., et al. (2008) Redox regulation of diaphragm proteolysis during mechanical ventilation. Am J Physiol Regulatory Integrative Comp Physiol: 294(5):R1608-1617
Merbl, Y. and Kirschner M.W. (2009) "Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays." PNAS 10 (8): 2543-2548.
Mitra, S., et al. (2009) "Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease." J. Biol. Chem. 284(7): 4398-4403.
Pacheco, C.D., et al. (2009) "Tau deletion exacerbates the phenotype of Niemann–Pick type C mice and implicates autophagy in pathogenesis." Hum. Mol. Genet. 18(5): 956-965.
Page, E.L., et al. (2008) "Hypoxia-inducible Factor- α Stabilization in Non-hypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion." Mol. Biol. Cell 19: 86-94.
Sampathu, D.M., et al. (2003) "Ubiquitination of α-synuclein is not required for formation of pathological inclusions in α--Synucleinopathies." Am. J. Path. 163: 91-100.
Sato K., et al. (2004) "Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel." J. Biochem. (Tokyo) 136(6): 777-785.
Shen, H-W., et al. (2009) "Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats." J. Neurosci. 29 (9): 2876-2884
Sparks, S. E., et al. (2005) "Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy." Glycobiology 15(11): 1102-1110.
Vazeille, E., et al. (2008) "The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially down-regulated during recovery after immobilization-induced muscle atrophy." Am. J. Physiol. Endocrinol .Metab. 295(5): E1181-E1190.
Yan, Z., et al. (2006). "Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia." J. Biol. Chem. 281(40): 29684-29692.
Yuksek, K., et al. (2009) "Ubiquitin-Independent Degradation of Hepatitis C Virus F Protein." J. Virol. 83(2): 612-621.
Zollars, E. S., et al. (2006). "Simple electrostatic model improves designed protein sequences." Protein Sci. 15(8): 2014-2018.
