An Ankyrin-Repeat Ubiquitin-Binding Domain Determines TRABID's Specificity for Atypical Ubiquitin Chains pp62 - 71

Authors:

Julien D F Licchesi, Juliusz Mieszczanek, Tycho E T Mevissen, Trevor J Rutherford, Masato Akutsu, Satpal Virdee, Farid El Oualid, Jason W Chin, Huib Ovaa, Mariann Bienz and David Komander

Journal Citation:

Nature Structural & Molecular Biology, Vol. 19, No. 1. (11 December 2011), pp. 62-71. doi:10.1038/nsmb.2169

Date Published:

December 11, 2011

The OTU domain deubiquitinase TRABID specifically hydrolyzes atypical Lys29- and Lys33-linked diubiquitin chains. Structural analysis of TRABID reveals an unpredicted ankyrin-repeat domain that binds ubiquitin and is crucial for TRABID efficiency and linkage specificity in vitro and in vivo.

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