Inhibitors

Time-lapse photography of HeLa cells expressing histone H2B-GFP is shown. Addition of 12 µM proTAME causes these cells to arrest in metaphase for 8 hours or more, with subsequent death in a large part of the population. The most comprehensive range of small molecule and protein inhibitors for a variety of in vitro and in vivo applications. Video Credit: Professor Randy King 2012

Product Highlight: proTAME, an APC/C Ligase Inhibitor

  • Cell-permeable
  • Induces mitotic arrest
  • Watch it in action!
E1 Activating
I-502

Nedd8 - E1 Enzyme (NAE Inhibitor)

Synthetic

1 mg

$125 Data Sheet Buy / Info
E3 Ligase
I-440 proTAME - E3 Ligase, APC/C 1 mg $215 Data Sheet Buy / Info
I-444

Apcin

5 mg vial

$155 Data Sheet Buy / Info
Deconjugating
UL-441

HA-GABARAP Vinyl Sulfone

Human Recombinant

25 µg

$269 Data Sheet Buy / Info
UL-446

HA-GATE16 Vinyl Sulfone

human recombinant

25 µg

$269 Data Sheet Buy / Info
UL-451

HA-LC3/MAP1LC3A Vinyl Sulfone

human recombinant

25 µg

$269 Data Sheet Buy / Info
UL-603

ISG15 Vinyl Sulfone

human recombinant

50 µg

$269 Data Sheet Buy / Info
UL-801

NEDD8 Aldehyde

human recombinant

50 µg

$159 Data Sheet Buy / Info
UL-802

NEDD8 Vinyl Sulfone

human recombinant

50 µg

$269 Data Sheet Buy / Info
UL-803

FLAG-NEDD8 Vinyl Sulfone

human recombinant

25 µg

$269 Data Sheet Buy / Info
Deubiquitinating
U-203

Ubiquitin-Vinyl Methyl Ester

Human Recombinant

50 µg

$269 Data Sheet Buy / Info
U-212

HA-Ubiquitin Vinyl Sulfone

human recombinant

25 µg

$235 Data Sheet Buy / Info
U-201 Ubiquitin Aldehyde (Ub-H) Human Recombinant

50 μg

$129 Data Sheet Buy / Info
U-211

HA-Ubiquitin Aldehyde

human recombinant

50 µg

$145 Data Sheet Buy / Info
U-214
New

Ubiquitin-Propargylamide

Human Recombinant

50 µg

$199 Data Sheet Buy / Info
Proteasome
2267

Lactacystin

synthetic

200 µg

$265 Data Sheet Buy / Info
I-100

clasto-lactacystin ß-lactone

Synthetic

200 µg, 1 mg

$1239 $325 Data Sheet Buy / Info
I-110

Epoxomicin

synthetic

200 µg, 1 mg

$665 $265 Data Sheet Buy / Info
I-120

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Synthetic

200 µg, 1 mg

$985 $245 Data Sheet Buy / Info
I-130

z-Leu-Leu-Leu-CHO (MG-132)

synthetic

5 mg

$125 Data Sheet Buy / Info
I-135

Z-Leu-Leu-Nva-CHO (MG-115)

Synthetic

5 mg

$79 Data Sheet Buy / Info
I-150

Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Synthetic

1 mg

$59 Data Sheet Buy / Info
I-190

Me4BodipyFL-Ahx3Leu3VS (Proteasome Activity Probe)

Synthetic

50 µg

$319 Data Sheet Buy / Info
I-197

b-AP15 (VLX1500)

Synthetic

200 μg  1 mg

$55 $375 Data Sheet Buy / Info
I-200
New

PS-341

Synthetic

5 mg

$189 Data Sheet Buy / Info
SUMO
UL-702

SUMO1 Vinyl Sulfone

human recombinant

50 µg

$269 Data Sheet Buy / Info
UL-703

HA-SUMO1 Vinyl Sulfone

human recombinant

50 µg

$269 Data Sheet Buy / Info
UL-759

HA-SUMO2 Vinyl Sulfone

human recombinant

50 µg

$275 Data Sheet Buy / Info
UL-769

HA-SUMO3 Vinyl Sulfone

human recombinant

50 µg

$269 Data Sheet Buy / Info
Autophagy
0741

GF 109203X

1 mg

10 mg

$75 $159 Data Sheet Buy / Info
1097

Taxol

10 mg 50 mg

$119 $439 Data Sheet Buy / Info
1130

LY 294002 hydrochloride

5 mg

25 mg

$119 $505 Data Sheet Buy / Info
1138

Thapsigargin

1 mg

$99 Data Sheet Buy / Info
1190

Pepstatin A

10 mg

$95 Data Sheet Buy / Info
1232

Wortmannin

1 mg 

5 mg

$85 $319 Data Sheet Buy / Info
1292

Rapamycin

1 mg

$235 Data Sheet Buy / Info
1334

Bafilomycin A1

10 µg

$119 Data Sheet Buy / Info
1370

Sphingosine-1-phosphate

1 mg

$159 Data Sheet Buy / Info
1391

NF 449

10 mg 50 mg

$189 $795 Data Sheet Buy / Info
1418

Resveratrol

100 mg

$99 Data Sheet Buy / Info
1544

(±)-Bay K 8644

10 mg, 50 mg

$159 $655 Data Sheet Buy / Info
2163

Z-VAD-FMK

1 mg

$209 Data Sheet Buy / Info
2706

Temozolomide

10 mg, 50 mg

$85 $339 Data Sheet Buy / Info
3093

Dorsomorphin dihydrochloride

10 mg 50 mg

$175 $735 Data Sheet Buy / Info
3516

Tunicamycin

10 mg

$145 Data Sheet Buy / Info
3993

EB 1089

1 mg

$169 Data Sheet Buy / Info
4247

Torin 1

10 mg, 50 mg

$225 $945 Data Sheet Buy / Info
UL-441

HA-GABARAP Vinyl Sulfone

Human Recombinant

25 µg

$269 Data Sheet Buy / Info
UL-455
New

MAP1LC3A-Rhodamine110

Human Recombinant

50 µg

$399 Data Sheet Buy / Info
Heat Shock Proteins
I-600

VER 155008 (HSP70 inhibitor)

Synthetic

100 µg

$55 Data Sheet Buy / Info
I-605

Geldanamycin (HSP90 inhibitor)

Synthetic 100 µg $110 Data Sheet Buy / Info
I-610 17-AAG (HSP90 inhibitor) Synthetic 100 µg $55 Data Sheet Buy / Info
I-615 Radicicol (HSP90 inhibitor) Synthetic 100 µg $55 Data Sheet Buy / Info