E3 Ligase

Ubiquitin modification of substrate proteins is achieved by the activity of E1 activating, E2 conjugating and E3 ligase enzymes. Substrate proteins can be modified with one (mono-ubiquitination) or many (poly-ubiquitination) molecules of ubiquitin, and each type of modification has distinct regulatory fates. E3 ligases number in the thousands and have the highest level of specificity for the target protein to be modified by ubiquitin or ubiquitin-like modifiers (UBL).


Accessory Proteins
AP-100

HSP70/HSPA1A

Human recombinant

50 µg, 100 µg

295.00 375.00 Buy / Info
AP-110

DNAJB1/HSP40

Human recombinant

50 µg

165 Data Sheet Buy / Info
AP-120

E6, Human Papillomavirus type 16

Viral Recombinant

25 μg

129 Data Sheet Buy / Info
AP-140

HSP60/HSPD1

Human recombinant

50 µg

255 Data Sheet Buy / Info
AP-150

HSP10/HSPE1

Human recombinant

50 µg

255 Data Sheet Buy / Info
AP-160

HSP90α/HSP90AA1

Human recombinant

50 µg

265 Data Sheet Buy / Info
AP-180

PINK1 Kinase

T. castaneum Recombinant

100 µg

349 Data Sheet Buy / Info
AP-182

PINK1 Kinase

Pediculus humanus recombinant

100 µg

349 Data Sheet Buy / Info
AP-190
New

TDP-43/TARDBP Protein

Human Recombinant

100 µg

299 Data Sheet Buy / Info
SP-480

His6-α-Synuclein

Human Recombinant

500 µg

349 Data Sheet Buy / Info
SP-485

α-Synuclein

Human Recombinant

500 µg

395 Data Sheet Buy / Info
SP-486
New

α-Synuclein (low endotoxin)

Human recombinant

500 µg

449 Data Sheet Buy / Info
SP-490

Miro1

Human Recombinant

100 µg

205 Data Sheet Buy / Info
SP-495
New

Tau 441 (2N4R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-496
New

Tau K18/Tau PHF Core

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-497
New

Tau 352 (0N3R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-498
New

Tau 381 (1N3R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-499
New

Tau 383 (0N4R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-500
New

Tau 441 (2N4R), Δ306-311

Human recombinant

100 µg

275 Data Sheet Buy / Info
SP-501
New

Tau 412 (1N4R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-502
New

Tau 410 (2N3R)

Human recombinant

100 µg

295 Data Sheet Buy / Info
SP-505
New

Tau Ladder

Human recombinant

50 µg

295 Data Sheet Buy / Info
SP-600
New

BRD4 (49-460), FLAG-tag, His-tag

Human recombinant

100 µg

351 Data Sheet Buy / Info
Activity Kits
K-102

MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate

Human Recombinant

1 Kit

395 Data Sheet Buy / Info
K-200B

Mdm2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

Human Recombinant

1 Kit

565 Data Sheet Buy / Info
K-210

Mdm2/HDM2 Ubiquitin Ligase Kit - S5a Substrate

Human Recombinant

1 Kit

475 Data Sheet Buy / Info
K-220

RNF4 Ubiquitin Ligase Kit - di-SUMO3 Substrate

Human Recombinant

1 Kit

325 Data Sheet Buy / Info
K-230

E6AP Ubiquitin Ligase Kit - S5a Substrate

Human Recombinant

1 Kit

395 Data Sheet Buy / Info
K-240

E6AP/E6 Ubiquitin Ligase Kit - p53 Substrate

Human Recombinant

1 Kit

495 Data Sheet Buy / Info
K-250

XIAP Ubiquitin Ligase Kit - Diablo Substrate

Human Recombinant

1 Kit

395 Data Sheet Buy / Info
K-260

cIAP-1/HIAP2 Ubiquitin Ligase Kit

human recombinant

1 Kit

355 Data Sheet Buy / Info
K-270

ITCH/AIP4 Ubiquitin Ligase Kit

Human Recombinant

kit

395 Data Sheet Buy / Info
K-280

CHIP Ubiquitin Ligase Kit - Glow-Fold Substrate

Human Recombinant

1 Kit

455 Data Sheet Buy / Info
K-290

HSP70/HSP40 Glow-Fold Protein Refolding Kit

Human Recombinant

1 Kit

475 Data Sheet Buy / Info
K-300

HSP60/HSP10 Glow-Fold Protein Refolding Kit

Human Recombinant

1 Kit

475 Data Sheet Buy / Info
Enzymes
E3-160

Parkin

Human Recombinant

25 µg

365 Data Sheet Buy / Info
E3-162

Parkin, W403A

Human Recombinant

25 µg

319 Data Sheet Buy / Info
E3-164

Parkin, C431S

human recombinant

100 µg

305 Data Sheet Buy / Info
E3-166
New

Parkin, pS65

human recombinant

25 µg

369 Data Sheet Buy / Info
E3-202

Mdm2/HDM2, GST-tag

Human Recombinant

50 µg

279 Data Sheet Buy / Info
E3-204

Mdm2/HDM2

Human Recombinant

50 µg

325 Data Sheet Buy / Info
E3-210

RNF4

Human Recombinant

50 µg

269 Data Sheet Buy / Info
E3-220

CHIP/Stub1

Human Recombinant

50μg

269 Data Sheet Buy / Info
E3-230

E6AP/UBE3A

Human Recombinant

50 μg

279 Data Sheet Buy / Info
E3-240

HOIP Catalytic Domain, His6-tag, MBP-tag

Human Recombinant

100 µg

269 Data Sheet Buy / Info
E3-250

NleL Catalytic Domain

E. coli Recombinant

100 µg

269 Data Sheet Buy / Info
E3-260

ITCH/AIP4, isoform 2

Human Recombinant

100 µg

275 Data Sheet Buy / Info
E3-270

UBE4B, His6-tag

Human Recombinant

50 µg

275 Data Sheet Buy / Info
E3-280

cIAP-1/HIAP-2

Human recombinant

50 µg

179 Data Sheet Buy / Info
E3-285

cIAP-2/HIAP-1, His10-tag

Human recombinant

50 µg

181 Data Sheet Buy / Info
E3-290

NEDD4, His6-tag

human recombinant

50 µg

269 Data Sheet Buy / Info
E3-295

Livin α/BIRC7 isoform 2

Human Recombinant

50 µg

185 Data Sheet Buy / Info
E3-300

Livin β/BIRC7 isoform 1

Human Recombinant

50 µg

185 Data Sheet Buy / Info
E3-302

HECTD2

Human recombinant

25 µg

185 Data Sheet Buy / Info
E3-304

RNF114

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-410

CUL1/RBX1 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-411
New

CUL1 (Neddylated)/RBX1 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-420

CUL2/RBX1 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-421
New

CUL2 (Neddylated)/RBX1

Human Recombinant

25 µg

$449 Buy / Info
E3-430
New

CUL3/RBX2 Complex

Human Recombinant

25 µg

$351 Data Sheet Buy / Info
E3-431
New

CUL3 (Neddylated)/RBX2 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-440

CUL4A/RBX1 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-441
New

CUL4A (Neddylated)/RBX1 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-450
New

CUL5/RBX2 Complex

Human Recombinant

25 µg

$351 Data Sheet Buy / Info
E3-451
New

CUL5 (Neddylated)/RBX2 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-500

DDB1/CRBN Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-501
New

DDB1

Human Recombinant

50 µg

$351 Data Sheet Buy / Info
E3-502
New

DDB1/DCAF16 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-503
New

DDB1/DCAF8 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-520

SKP1

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-521

SKP1/SKP2 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-525
New

SKP1/FBXO7 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-526
New

SKP1/FBXO7/CUL1/RBX1 Complex

Human Recombinant

25 µg

$449 Data Sheet Buy / Info
E3-600

Elongin B/C-VHL Complex

Human recombinant

50 µg

285 Data Sheet Buy / Info
E3-650

CUL4A/RBX1/DDB1/CRBN

Human recombinant

25 µg

285 Data Sheet Buy / Info
E3-655

VHL/ELOB/ELOC/CUL2/RBX1 Complex

Human recombinant

25 µg

285 Data Sheet Buy / Info
Inhibitors
I-440 proTAME - E3 Ligase, APC/C 1 mg 255 Data Sheet Buy / Info
I-444

Apcin

5 mg vial

$155 Data Sheet Buy / Info