Proteasome

Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome.

Blackburn C, Barrett C, Blank JL, et al. "Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome." Med. Chem. Commun. 2012 May 30;3(6):710–719. 

PubMed ID: 
10.1039/C2MD20060K
Product(s) Referenced: 
purified human erythrocyte and peripheral blood monocyte 20S proteasomes, recombinant proteasomal activator PA28alpha, Z-LLE-AMC

Changes in 20S subunit composition are largely responsible for altered proteasomal activities in experimental autoimmune encephalomyelitis.

Zheng, J. et al. (2012) "Changes in 20S subunit composition are largely responsible for altered proteasomal activities in experimental autoimmune encephalomyelitis." J. Neurochem. 121(3): 486–494.

PubMed ID: 
22353035
Product(s) Referenced: 
immunoproteasome, standard proteasome

The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes.

Xu, H. et al. (2012) "The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes." Biochim. Biophys. Acta 1823(4): 818–825.

PubMed ID: 
22285817
Product(s) Referenced: 
MG132, Suc-Leu-Leu-Val-Tyr-AMC pep- tide substrate

Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature.

Tsihlis, N.D. et al. (2012) "Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature." Nitric Oxide 27(1): 50–58.

PubMed ID: 
22561112
Product(s) Referenced: 
recombinant PA28, Bz-VGR-AMC (trypsin-like), Suc-LLVY-AMC (chymotrypsin-like), Z-LLE-AMC (caspase-like)

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).

Thompson, J.W. et al. (2012) "Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)." J. Biol. Chem. 287(10): 7357–7365.

PubMed ID: 
22253436
Product(s) Referenced: 
MG132

Inhibitor Mediated Protein Degradation.

Long, M.J.C. et al. (2012) "Inhibitor Mediated Protein Degradation." Chemistry & Biology 19(5): 629–637.

PubMed ID: 
22633414
Product(s) Referenced: 
immunoproteasome from mouse spleen, Purified 20S proteasome from HeLa, IU1

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes.

Issaenko, O.A. and Amerik, A.Y. (2012) "Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes." Cell cycle (Georgetown, Tex.) 11(9).

PubMed ID: 
22510564
Product(s) Referenced: 
Ubiquitin aldehyde (Ubal), 20S Human proteasome

Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain.

Gustin, J.K. et al. (2012) "Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain." J. Biol. Chem. 287(18): 14837–14850.

PubMed ID: 
22383521
Product(s) Referenced: 
MG132

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.

Bernstein, S.H. et al. (2012) "The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives." Blood 119(14): 3321–3329.

PubMed ID: 
22323447
Product(s) Referenced: 
20S proteasome

The ubiquitin-activating enzyme (E1) of the early-branching eukaryote Giardia intestinalis shows unusual proteolytic modifications and play important roles during encystation.

Niño, C.A. et al. (2012) "The ubiquitin-activating enzyme (E1) of the early-branching eukaryote Giardia intestinalis shows unusual proteolytic modifications and play important roles during encystation." Acta tropica. 2012 Apr 4.

PubMed ID: 
22498829
Product(s) Referenced: 
MG132
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