Proteasome

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA(+) Lon Protease.

Lu, B. et al. (2012) "Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA(+) Lon Protease." Mol. Cell.

PubMed ID: 
23201127
Product(s) Referenced: 
20S proteasome

Non-competitive modulation of the proteasome by imidazoline scaffolds overcome bortezomib resistant and delay MM tumor growth in vivo.

Lansdell, T.A. et al. (2012) "Non-competitive modulation of the proteasome by imidazoline scaffolds overcome bortezomib resistant and delay MM tumor growth in vivo." ACS Chem. Biol.

PubMed ID: 
23198928
Product(s) Referenced: 
purified proteasome particles, Suc-LLVY-AMC, Z-ARR-AMC, Z-LLE-AMC

Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells.

Henle, A.M. et al. (2012) "Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells." J. Immunol.

PubMed ID: 
23180824
Product(s) Referenced: 
Suc-LLVY-AMC, synthetic lactacystin, reaction buffer (25 mM HEPES, 0.5 mM EDTA, pH 7.6), immunoproteasome, PA28 activator alpha subunit, purified human 20S proteasome

Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides.

Held, S.A.E. et al. (2012) "Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides." Cancer Immunol. Immunother.

PubMed ID: 
23184338
Product(s) Referenced: 
isolated and purified 20S proteasomes

Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions.

Guan, B. et al. (2012) "Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions." Neoplasia 14(10): 986–993.

PubMed ID: 
23097632
Product(s) Referenced: 
MG132

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

Foy, R.L. et al. (2012) "Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1." Hum. Mol. Genet.

PubMed ID: 
23001567
Product(s) Referenced: 
lactacystin, MG132

Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS.

Dechavanne, V. et al. (2012) "Purification and separation of the 20S immunoproteasome from the constitutive proteasome and identification of the subunits by LC-MS." Protein Expr. Purif.

PubMed ID: 
23147206
Product(s) Referenced: 
Rabbit AP-123 polyclonal antibody, anti-beta2-20S human proteasome

Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice.

Carvalho, A.N. et al. (2012) "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice." Mol. Neurobiol.

PubMed ID: 
23129554
Product(s) Referenced: 
Z-leucine-leucine-glutamic acid-7-amido-4-methylcoumarin (Z-LLE-AMC), Boc-leucine-arginine-arginine-7-amido-4-methylcoumarin (Boc-LRR-AMC), succcinyl-leucine-leucine-valine-tyro-sine-7-amido-4-methylcoumarin (Suc-LLVY-AMC), isopeptidase inhibitor (Ubiquitin aldehyde [Ubal]), MG132,

Skp1-Cul1-F-box Ubiquitin Ligase (SCFβTrCP)-Mediated Destruction of the Ubiquitin-Specific Protease USP37 During G2-phase Promotes Mitotic Entry.

Burrows, A.C. et al. (2012) "Skp1-Cul1-F-box Ubiquitin Ligase (SCFβTrCP)-Mediated Destruction of the Ubiquitin-Specific Protease USP37 During G2-phase Promotes Mitotic Entry." J. Biol. Chem.

PubMed ID: 
23027877
Product(s) Referenced: 
MG132, UbcH10 antibody

Selective Cytotoxicity of Amidinopiperidine Based Compounds Towards Burkitt’s Lymphoma Cells Involves Proteasome Inhibition.

Gobec, M. et al. (2012) "Selective Cytotoxicity of Amidinopiperidine Based Compounds Towards Burkitt’s Lymphoma Cells Involves Proteasome Inhibition." PLoS ONE 7(7): e41961.

PubMed ID: 
22860040
Product(s) Referenced: 
purified human 20S proteasome
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