Inhibitor

GST:Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.

Zhang, S. et al. (2012) "GST:Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage." J. Biol. Chem.

PubMed ID: 
23233665
Product(s) Referenced: 
ATP regenerating solution (ENS), ubiquitin aldehyde, HeLa S100 fraction, Recombinant human E1 ubiquitin activating enzyme, Recombinant human ubiquitin, Recombinant human ubiquitin K48R, Recombinant human ubiquitin K63R, Recombinant human UbcH5c, Recombinant human Cdc34, Recombinant human UbcH2

Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells.

Henle, A.M. et al. (2012) "Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells." J. Immunol.

PubMed ID: 
23180824
Product(s) Referenced: 
Suc-LLVY-AMC, synthetic lactacystin, reaction buffer (25 mM HEPES, 0.5 mM EDTA, pH 7.6), immunoproteasome, PA28 activator alpha subunit, purified human 20S proteasome

Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions.

Guan, B. et al. (2012) "Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions." Neoplasia 14(10): 986–993.

PubMed ID: 
23097632
Product(s) Referenced: 
MG132

Interferon-γ Causes Cardiac Myocyte Atrophy via Selective Degradation of Myosin Heavy Chain in a Model of Chronic Myocarditis.

Cosper, P.F. et al. (2012) "Interferon-γ Causes Cardiac Myocyte Atrophy via Selective Degradation of Myosin Heavy Chain in a Model of Chronic Myocarditis." Am. J. Pathol. 181(6): 2038–2046.

PubMed ID: 
23058369
Product(s) Referenced: 
MG-132

Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice.

Carvalho, A.N. et al. (2012) "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice." Mol. Neurobiol.

PubMed ID: 
23129554
Product(s) Referenced: 
Z-leucine-leucine-glutamic acid-7-amido-4-methylcoumarin (Z-LLE-AMC), Boc-leucine-arginine-arginine-7-amido-4-methylcoumarin (Boc-LRR-AMC), succcinyl-leucine-leucine-valine-tyro-sine-7-amido-4-methylcoumarin (Suc-LLVY-AMC), isopeptidase inhibitor (Ubiquitin aldehyde [Ubal]), MG132,

Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons.

Caldeira, M.V. et al. (2012) "Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons." Biochim. Biophys. Acta.

PubMed ID: 
23069389
Product(s) Referenced: 
HA-Ub-VS

Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.

Frisan, T. et al. (2012) "Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth." FASEB J.

PubMed ID: 
22932395
Product(s) Referenced: 
Ub-VS functional probe

High yield expression of catalytically active USP18 using a Trigger Factor fusion system.

Basters, A. et al. (2012) "High yield expression of catalytically active USP18 using a Trigger Factor fusion system." BMC Biotechnol. 12(1): 56.

PubMed ID: 
22916876
Product(s) Referenced: 
HA-ISG15 vinyl sulfone (ISG15-VS), ISG15-amidomethyl coumarin (AMC), HA-Ubiquitin (Ub-VS)

Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB.

Kensche, T. et al. (2012) "Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB." J. Biol. Chem. 287(28): 23626–23634.

PubMed ID: 
22605335
Product(s) Referenced: 
creatine phosphokinase, HeLa-S-100 fraction II, ubiquitin, ubiquitin aldehyde

2163

Z-VAD-FMK

$219.00
Information
MW: 
467.49
Solubility: 
Soluble to 9.35 mg/ml in DMSO
Activity: 

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Use & Storage
Storage: 
Store at -20°C
Literature
References: 

 

Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21. PMID: 8670109.

Kunstle et al (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 55 5. PMID: 9093874.

Garcia-Calvo et al (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 273 32608. PMID: 9829999.

King et al (1998) Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 12 1553. PMID: 9766499.

UK Price: 
340
Euro Price: 
230
CHF Price: 
280
SKK Price: 
2010
DKK Price: 
1680
NOK Price: 
175
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