E1 Activating

SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Fernández-Sáiz, V. et al. (2012) "SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma." Nat. Cell Biol.

PubMed ID: 
23263282
Product(s) Referenced: 
E1

Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator.

Zhuang, M. et al. (2012) "Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator." Mol. Cell.

PubMed ID: 
23201124
Product(s) Referenced: 
UbcH5b, UBE1, ubiquitin

1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity.

Zhang, Z. et al. (2012 "1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity." J. Biol. Inorg. Chem. 17(8): 1257–1267.

PubMed ID: 
23053530
Product(s) Referenced: 
purified human 20S proteasome, human ubiquitin activating enzyme E1, UbcH10

Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage.

Zang, Y. et al. (2012) "Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage." Rice 5(1): 24.

PubMed ID: 
10.1186/1939-8433-5-24
Product(s) Referenced: 
E1 enzyme, K48R ubiquitin, K63R ubiquitin, reaction buffer, Ub, Ubc13, Uev1A, ubiquitin-AMC, nonbiotinylated USP2 catalytic domain, USP10, USP47, USP5, USP7

Identification of insulin receptor substrate 1’s degradation determinants for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

Xu, X. et al. (2012) "Identification of insulin receptor substrate 1’s degradation determinants for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination." J. Biol. Chem. 287(48):40758-66.

PubMed ID: 
23045529
Product(s) Referenced: 
E1, MG132

A subset of mixed lineage leukemia proteins has PHD domain-mediated E3 ligase activity.

Wang, J. et al. (2012) "A subset of mixed lineage leukemia proteins has PHD domain-mediated E3 ligase activity." J. Biol. Chem.

PubMed ID: 
23129768
Product(s) Referenced: 
CDC34 antibody, HA tagged ubiquitin, human recombinant CDC34, human recombinant RAD6, human recombinant UBCH5c, human recombinant UBE1, recombinant histone H2A, recombinant histone H2B, recombinant histone H3, recombinant histone H4

Electrophilic Adduction of Ubiquitin Activating Enzyme E1 by N,N-Diethyldithiocarbamate Inhibits Ubiquitin Activation and is Accompanied by Striatal Injury in the Rat.

Viquez, O.M. et al. (2012) "Electrophilic Adduction of Ubiquitin Activating Enzyme E1 by N,N-Diethyldithiocarbamate Inhibits Ubiquitin Activation and is Accompanied by Striatal Injury in the Rat." Chem. Res. Toxicol.

PubMed ID: 
22874009
Product(s) Referenced: 
recombinant human His6-ubiquitin activating enzyme

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.

Shibata, Y. et al. (2012) "p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO." Nat Commun 3: 1061.

PubMed ID: 
22990857
Product(s) Referenced: 
His6-UbcH13/Uev1a, His6-UBE1, K48 only ubiquitin, K63 only ubiquitin, Lys48-linked polyubiquitin chains, Lys63-linked polyubiquitin chains, UbcH5c, wild-type ubiquitin

IKK{epsilon} phosphorylates TRAF2 to promote mammary epithelial cell transformation.

Shen, R.R. et al. (2012) "IKK{epsilon} phosphorylates TRAF2 to promote mammary epithelial cell transformation." Mol. Cell. Biol. 32(23):4756-68. 

PubMed ID: 
23007157
Product(s) Referenced: 
Recombinant E1 ubiquitin activating enzyme, Ubc13 E2 enzyme, ubiquitin

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

Mössinger, J. et al. (2012) "Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch." EMBO Rep. 13(12):1087-94.

PubMed ID: 
23146885
Product(s) Referenced: 
E1 (UBE1), E2 (UbcH7)
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