E1 Activating

GST:Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.

Zhang, S. et al. (2012) "GST:Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage." J. Biol. Chem.

PubMed ID: 
23233665
Product(s) Referenced: 
ATP regenerating solution (ENS), ubiquitin aldehyde, HeLa S100 fraction, Recombinant human E1 ubiquitin activating enzyme, Recombinant human ubiquitin, Recombinant human ubiquitin K48R, Recombinant human ubiquitin K63R, Recombinant human UbcH5c, Recombinant human Cdc34, Recombinant human UbcH2

BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation.

Shabbeer, S. et al. (2012) "BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation." Oncogene.

PubMed ID: 
23246971
Product(s) Referenced: 
recombinant His-cyclin B, HA-ubiquitin, E1, UbcH5c, UbcH1, Ubc13-MMS2, UbcH10, ATP (ERS), His-BRCA1, His-BARD1

CHFR is important for the first wave of ubiquitination at DNA damage sites.

Liu, C. et al. (2012) "CHFR is important for the first wave of ubiquitination at DNA damage sites." Nucleic Acids Res.

PubMed ID: 
23268447
Product(s) Referenced: 
HA-Ub, E1, UbcH5C, Ubc13/Uev1a

Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation through p63.

Jung, Y.-S. et al. (2012) "Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation through p63." J. Invest. Dermatol.

PubMed ID: 
23235527
Product(s) Referenced: 
E1, E2, ubiquitin

Defective in Mitotic Arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.

Hernandez-Ortega, S. et al. (2012) "Defective in Mitotic Arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation." J. Biol. Chem.

PubMed ID: 
23264631
Product(s) Referenced: 
E1 enzyme (Uba1), E2 complex (HIS6x-Ubc13, HIS6x-Mms2),

Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).

Hebron, M.L. et al. (2012) "Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6)." J. Biol. Chem.

PubMed ID: 
23258539
Product(s) Referenced: 
recombinant human ubiquitin, recombinant UbcH7, E1 recombinant enzyme,
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