UL-930

New
Material Data Sheet

FUBI/(MNSFß)

Price: $195.00
Catalog #: UL-930

FUBI/(MNSFß)

Price: 
$195
Quantity: 
250 µg
Data Sheet: 

The ubiquitin-like protein FUBI/MNSFß (Monoclonal Nonspecific Suppressor Factor Beta) is encoded by the FAU gene, and is translated as a pro-form consisting of FUBI fused to the ribosomal S30 protein.  S30 is cleaved in a post-translational reaction, releasing the mature 74 amino acid FUBI/MNSFß protein.  FUBI has a C-terminal gly-gly motif common to many ubiquitin-like proteins.

FUBI/MNSFß conjugation to Bcl-G has been shown to regulate the ERK 1/2-MAPK cascade in macrophage cell lines, and may be implicated in TLR4-mediated signal transduction.  Conjugation to endophilin II regulates dectin-1-mediated phagocytosis and inflammatory responses, and may be implicated in TLR2 signaling pathway.

Product Information

Stock: 
X mg/ml (X µM) in 50 mM Hepes pH 8.0, 100 mM NaCl, 1mM DTT
MW: 
7.8 kDa
Purity: 
> 95% by SDS-PAGE
Storage: 
Store at -80°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Rossman, T.G. et al. (2003) Oncogene 22: 1817-1821

Nakamura, M. & Omura, S. (2008) Biosci. Biotech. Biochem. 72: 1915-1920

Nakamura, M. & Yamaguchi, S. (2006) J. Biol. Chem. 281: 16861-16969

Nakamura, M & Watanabe, N. (2010) Biochem, Biophys. Res. Comm. 15: 275-61

Nakamura, M. et al. (2012) Mol. Cell Biochem. 364: 39-43