UL-801

Material Data Sheet

NEDD8 Aldehyde

Price: $150.00
Catalog #: UL-801

NEDD8 Aldehyde

Price: 
150
Quantity: 
50 µg
Data Sheet: 
application/pdf iconul-801-nedd8-aldehyde.pdf

Also known as: NEDD8-H

A potent and highly specific inhibitor of NEDD8-specific isopeptidases (NEDP1 or SENP8). This protein blocks the hydrolysis of poly-NEDD8chains on substrate proteins in vitro and thus enhances poly-NEDD8 chain accumulation.

Product Information

MW: 
9.1 kDa
Purity: 
> 98 % by HPLC
Solubility: 
Soluble in DMSO up to 5 mg/ml. For best results, pellet dry compound prior to reconstitution.
Supplied: 
This is a lyophilized powder

Use & Storage

Use: 

Add directly to in vitro assay from the stock solution. Depending on conditions,
typical concentrations to fully inhibit NEDPs in vitro are 1-5 μM.

Storage: 
Store powder at -20°C. Store stock solution at -80°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Hemelaar J., et al. (2004) Mol. Cell. Biol. 24: 84-95
Mendoza H.M., et al. (2003) J. Biol. Chem. 278: 25637-25643
Reverter D., et al. (2005) J. Mol. Biol. 345: 141-151
Wu K., et al. (2003) J. Biol. Chem. 278: 288882-2888891