Material Data Sheet


Price: $159.00
Catalog #: UL-752


500 µg
Data Sheet: 

Also known as: SUMO-2 (SMT3A)

The ubiquitin-like SUMO-2 is conjugated to a variety of proteins in the presence of UbcH9 and the SAE1/SAE2 (human) or Aos1/Uba2 (yeast) activating enzyme. SUMO-2 is derived from the precursor pro-SUMO-2 (Accession # NM_006937). Human SUMO-2 shares 44% and 86% identity with SUMO-1 and SUMO-3 respectively. SUMOylation can occur without the requirement of a specific E3 ligase activity, where SUMO is transferred directly from UbcH9 to specific substrates. SUMOylated substrates are primarily localized to the nucleus (RanGAP-1, RANBP2, PML, p53, Sp100, HIPK2) but there are also cytosolic substrates (IκBα, GLUT1, GLUT4). SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation, transcriptional regulation, apoptosis and protein stability.

Product Information

X mg/ml (X μM) in 50 mM HEPES pH 8.0, 150 mM NaCl, 1mM DTT. Actual protein concentration will vary with specific Lot #.
11.6 kDa
> 95% by SDS-PAGE

Use & Storage


Typical in vitro concentrations for conjugate formation is 10-50 μM depending on conditions.

Store at -80°C once reconstituted. Avoid multiple freeze/ thaw cycles.



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