UL-702

Material Data Sheet

SUMO1 Vinyl Sulfone

Price: $250.00
Catalog #: UL-702

SUMO1 Vinyl Sulfone

Price: 
250
Quantity: 
50 µg
Data Sheet: 
application/pdf iconul-702-sumo1-vinyl-sulfone.pdf

Also known as: SUMO-VS

A potent and highly specific inhibitor of SUMO-specific isopeptidases (SENPs). This protein blocks the hydrolysis of poly-SUMO chains on substrate proteins in vitro and thus enhances poly- SUMO chain accumulation.

Product Information

MW: 
11.1 kDa
Purity: 
> 98% by HPLC
Solubility: 
X mg/ml (X μM) in 50 mM Hepes pH 7.0, 150mM sodium chloride, 10% glycerol. Actual concentration will vary with specific Lot #.
Supplied: 
This is a lyophilized powder

Use & Storage

Use: 

Add directly to in vitro assay from the stock solution. Depending on conditions, typical concentrations to fully inhibit SENPs in vitro are 1-5 μM. 

Storage: 
Store stock solution at -80°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Borodovsky A., et al. (2002) Chem.Biol. 9: 1149-1159
Borodovsky A., et al. (2005) Chem.Biochem. 6: 287-291
Hemelaar J., et al. (2004) Mol.Cell.Bio. 24: 84-95
Wang G., et al. (2003) Org. Lett. 5: 737-740