UBE-305

Material Data Sheet

S5a/Angiocidin Biotin

Price: $245.00
Catalog #: UBE-305

S5a/Angiocidin Biotin

Price: 
$245
Quantity: 
250 µg

S5a (Rpn10), a component of the 19S regulatory complex, functions as a receptor by binding to and recognizing poly-ubiquitinated proteins destined for 26S proteasome degradation. The protein recognizes ubiquitin chains and ubiquitin protein conjugates via two UIM (ubiquitin-interacting motif) domains. Detection with avidin-linked reagents allows for a higher efficiency and detection sensitivity than with other antibodies.

Product Information

Stock: 
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 250 mM NaCl, 5% glycerol, 1 mM DTT.
MW: 
43 kDa
Purity: 
> 95% by SDS-PAGE

Use & Storage

Use: 
Typical concentrations for in vitro assays are 1-5 μM depending on experimental conditions and detection method. 
Storage: 
Store at -80°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

 

Bajorek M. and Glickman M.H. (2004) Cell. Mol. Life Sci. 61:1579-1588

Deveraux Q., et al. (1994) J. Biol. Chem. 269: 7059-7061

Ferrell K.,  et al. (1996) FEBs. Lett. 381: 143-148

Mayor T.,  et all. (2005) Mol. Cell. Proteomics. 4:741-751.

Ventadour S.,  et al. (2007) J. Biol. Chem. 282: 5302-5309

Verma R,  et all. (2004) Cell. 118:99-110