SP-505

New
Material Data Sheet

Tau Ladder

Price: $295.00
Catalog #: SP-505

Tau Ladder

Price: 
$295
Quantity: 
50 µg
Data Sheet: 

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation can result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple isoforms of Tau— this product contains equal amounts of the following isoforms: Tau 352 (0N3R), Tau 381 (1N3R), Tau 383 (0N4R), Tau 410 (2N3R), Tau 412 (1N4R) and Tau 441 (2N4R).  These recombinant proteins are untagged. 

Product Information

Stock: 
1 mg/ml in PBS pH 7.4, 1 mM DTT
MW: 
36.8 kDa (0N3R), 39.7 kDa (1N3R), 40.0 kDa (0N4R), 42.6 kDa (2N3R), 43.0 kDa (1N4R) and 45.9 kDa (2N4R)
Purity: 
> 95% by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue stain
Storage: 

Store at -80°C and avoid multiple freeze/thaw cycles