SP-495

New
Material Data Sheet

Tau 441 (2N4R)

Price: $275.00
Catalog #: SP-495

Tau 441 (2N4R)

Price: 
$275
Quantity: 
100 µg
Data Sheet: 

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation can result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple isoforms of Tau— this 441 amino acid isoform is known as “2N4R,” “Isoform Tau-F,” “Tau 441” or “Tau-4” and is referenced in UniProt as P10636-8.  This recombinant protein is untagged. 

Product Information

Stock: 
X mg/ml (X µM) in PBS pH 7.4
MW: 
46 kDa
Purity: 
>95% by SDS-PAGE under reducing conditions and visualized with Colloidal Coomassie Blue Stain.
Storage: 

Store at -80°C.  Avoid freeze/thaw cycles.