SP-486

New
Material Data Sheet

α-Synuclein (low endotoxin)

Price: $449.00
Catalog #: SP-486

α-Synuclein (low endotoxin)

Price: 
$449
Quantity: 
500 µg
Data Sheet: 

α-Synuclein is a member of a family of small, soluble proteins that also include β-, and γ-Synuclein.  α-Synuclein is predominantly expressed in neurons of the central nervous system, specifically in the presynaptic region of nerve terminals.  This protein cycles between a free, partially unfolded form and a helical, membrane-bound form.  α-Synuclein can aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates.  The fibrils and amyloidal forms are major components of Lewy Bodies and have been linked to the pathogenesis of Parkinson's disease dementia.  α-Synuclein aggregates can also be found associated with amyloid plaques in Alzheimer's disease.  This untagged recombinant protein may be used as an in vitro substrate for various Ubiquitin E3 ligases or in applications where low endoxtoxin is required.

Product Information

Stock: 
X mg/ml (X µM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT
MW: 
14 kDa
Purity: 
> 95% by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue stain. Endotoxin < 0.1 EU per milligram of protein using the LAL method.

Use & Storage

Use: 

Concentration for use in in vitro assays will depend on experimental conditions and detection methods.

Storage: 

Store at -80ºC.  Avoid freeze/thaw cycles.