I-615

Material Data Sheet

Radicicol (HSP90 inhibitor)

Price: $55.00
Catalog #: I-615
Radicicol (HSP90 inhibitor)
Price: 
$55
Quantity: 
100 µg
Data Sheet: 
Antifungal and antibiotic. Inhibits Heat Shock Protein 90 (HSP90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Product Information

FW: 
364.78
Structure: 
Purity: 
> 98% by HPLC
Solubility: 
Provided as a 10 mM stock solution in DMSO
Activity: 
Depending on the cell line, typical IC50 values in a 72 hour assay are ≤ 1 µM.
Storage: 
Store stock solution at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Oikawa, T., et al. (1993)  Eur.J.Pharmacol.  241:  221-227
Schulte, T.W., et al. (1999)  Mol.Endocrinol.  13:  1435-1448
Lee, M.O., et al. (2002)  Mol.Cell.Endocrinol.  188:  47-54