I-610

Material Data Sheet

17-AAG (HSP90 inhibitor)

Price: $55.00
Catalog #: I-610
17-AAG (HSP90 inhibitor)
Price: 
$55
Quantity: 
100 µg
Data Sheet: 

Inhibitor of heat shock protein 90 (HSP90) chaperone activity, and an analog of geldanamycin (Cat. No. I-605). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2, N-ras, Ki-ras and c-Akt.

Product Information

FW: 
585.7
Structure: 
Purity: 
>98% by HPLC
Solubility: 
Provided as a 10 mM stock solution in DMSO
Activity: 

IC50 = 31 nM

Storage: 
Store stock solution at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Schnur, R.C., et al. (1995).  J.Med.Chem.  38:  3806-3812
Hostein, I., et al. (2001).  Cancer Res.  61:  4003-4009
Yang, J., et al. (2001).  Cancer Res.  61:  4010-4016