I-605

Material Data Sheet

Geldanamycin (HSP90 inhibitor)

Price: $110.00
Catalog #: I-605

Geldanamycin (HSP90 inhibitor)

Price: 
$110
Quantity: 
100 µg
Data Sheet: 

Selectively inhibits heat shock protein 90 (HSP90). Binds to the ATP site of HSP90 (Kd = 1.2 µM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates anti-proliferative effects on breast cancer cells in a dose dependent manner.

Product Information

FW: 
550.64
Structure: 
Purity: 
>98% by HPLC
Solubility: 
Provided as a 10 mM stock solution in DMSO
Activity: 

Depending on cell line, typical EC50 values in a 72 hour assay are ≤ 1 µM.

Storage: 
Store stock solution at -20°C. Avoid multiple freeze/thaw cycles.
Purity: 
>98% by HPLC

Literature

References: 

Whitesell, L., et al. (1994)  Proc. Natl. Acad. Sci. U.S.A.  91:  8324-8328
Cardenas, M.E., et al. (1998)  Trends Biotechnol.  16:  427-433
Roe, S.M., et al. (1999)  J. Med. Chem.  42:  260-266
Lee, C.H., et al. (2012)  Biochimie.  94:  1382-1389