I-600

Material Data Sheet

VER 155008 (HSP70 inhibitor)

Price: $55.00
Catalog #: I-600

VER 155008 (HSP70 inhibitor)

Price: 
$55
Quantity: 
100 µg
Data Sheet: 

Novel adenosine-derived inhibitor of Heat Shock Protein 70 (HSP70). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds to Hsc70 and Grp78. 

Product Information

FW: 
556.41
Structure: 
Purity: 
>98% by HPLC
Solubility: 
Provided as a 10 mM stock solution in DMSO
Activity: 

IC50 = 0.5 µM in an in vitro assay using HSP70

Storage: 

Store stock solution at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Massey, A.J., et al. (2009) Cancer Chemother.Pharmacol. 66: 535-545 

Williamson, D.S., et al. (2009) J.Med.Chem. 52: 1510-1513 

Massey, A.J., et al. (2010) J.Med.Chem. 53: 7280-7286 

Macias, A.T., et al. (2011) J.Med.Chem. 54: 4034-4041