I-200

New
Material Data Sheet

PS-341

Price: $189.00
Catalog #: I-200

PS-341

Price: 
$189
Quantity: 
5 mg
Data Sheet: 

The dipeptide-boronic acid analogue PS-341 is the active ingredient in Bortezomib (Velcade, Millennium Pharmaceuticals).  This potent, cell permeable molecule inhibits primarily the chymotryptic activity of the proteasome without substantially altering tryptic or caspase-like activities.  PS-341 inhibits proliferation of a number of tumor cell lines with nanomolar potency, and is approved by the USFDA for the treatment of multiple myeloma. 

Product Information

FW: 
384
Solubility: 
Soluble in ethanol and DMSO to 200 mg/mL. Poorly soluble in water (estimated 5-10 uM).
Activity: 

IC50 = 9 nM reported for MM1.S multiple myeloma cell line (72 hour assay)

Storage: 
Store lyophilized material at -20°C. Avoid multiple freeze/thaw cycles after reconstitution.
Purity: 
>99% by HPLC and TLC

Literature

References: 

Adams, J. and Kauffman, M. (2004) Cancer Invest. 22: 304-311

Chauhan, D., et al. (2005) Cancer Cell 8: 407-419

Horton, T.M., et al. (2006) Cancer Chemother Pharmacol 58: 13-23