I-150

Material Data Sheet

Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Price: $45.00

Catalog #: I-150

Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Price:

$45

Quantity:

1 mg

Data Sheet:

150_zLLFCHO.pdf

Structure:

Purity:

> 95% by HPLC.

Solubility:

Soluble and stable in DMSO up to 15 mg/ml.

Activity:

20S proteasome K_i=350 nM

Peptide aldehydes form a covalent hemiacetal adduct with the 20S proteasome, inhibiting the chymotrypsin-like peptidase activity. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.

Storage:

Store DMSO stock at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References:

Myung J., et al. (2001) Med. Res. Rev. 4:245-273
Schauer S.L., et al. (1998) J. Immunol. 160:4398-4405
Vinitsky A., et al. (1992) Biochem. 31:9421-9428
Vinitsky A., et al. (1994) J. Biol. Chem. 269:29860-29860