I-150

Material Data Sheet

Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Price: $59.00
Catalog #: I-150

Z-Leu-Leu-Phe-CHO (Z-LLF-CHO)

Price: 
$59
Quantity: 
1 mg

Peptide aldehydes form a covalent hemiacetal adduct with the 20S proteasome, inhibiting the chymotrypsin-like peptidase activity. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.

Product Information

Structure: 
Purity: 
> 95% by HPLC.
Solubility: 
Soluble and stable in DMSO up to 15 mg/ml.
Activity: 

20S proteasome Ki=350 nM

Storage: 
Store DMSO stock at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Myung J., et al. (2001) Med. Res. Rev. 4:245-273
Schauer S.L., et al. (1998) J. Immunol. 160:4398-4405
Vinitsky A., et al. (1992) Biochem. 31:9421-9428
Vinitsky A., et al. (1994) J. Biol. Chem. 269:29860-29860