I-140

Material Data Sheet

Z-lle-Glu(OtBu)-Ala-Leu-CHO (Z-IE-OtBu-AL-CHO)

Price: $110.00

Catalog #: I-140

Z-lle-Glu(OtBu)-Ala-Leu-CHO (Z-IE-OtBu-AL-CHO)

Price:

$110

Quantity:

5mg

Data Sheet:

140_zIGAL.pdf

Structure:

Purity:

> 95% by HPLC.

Peptide aldehydes form a covalent hemiacetal adduct with the 20S proteasome, inhibiting the chymotrypsin-like peptidase activity. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.

Use & Storage

Use:

Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect.

Storage:

Store at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References:

Mori S., et al. (1995) J. Biol. Chem. 270:29447-29452
Myung J., et al. (2001) Med. Res. Rev. 4:245-273
Rodgers K.J. and Dean R.T. (2003) Intl. J. Biochem. Cell. Biol. 35:716-727
Vinitsky A., et al. (1994) J. Biol. Chem. 269:29860-29860