I-122

Material Data Sheet

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Price: $925.00
Catalog #: I-122

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Price: 
$925
Quantity: 
1 mg
Data Sheet: 
application/pdf icon122_zLLLbOh.pdf
Structure: 
Purity: 
95% by HPLC. Structure confirmed by <sup>1</sup>H-NMR.
Solubility: 
Soluble and stable in DMSO up to 15 mg/ml.
Activity: 
Ki = 0.023 nM vs. SDS-activated 20S Proteasome.

This peptide boronic acid is structurally similar to the peptide aldehyde MG-132 and also inhibits the chymotrypsin-like peptidase activity of the proteasome, but with much higher potency. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.

Use & Storage

Use: 
Highly potent and selective cell-permeable inhibitor of the proteasome.
Storage: 
Store at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Adams J., et al. (1998) Bioorg. Med. Chem. Lett. 8:333-338
Lee D.H. and Goldberg A.L. (1998) Tren. Cell. Biol. 8:397-403
McCormack T.A. et al, (1998) Biochem. 37:7792-7800
Myung J., et al. (2001) Med. Res. Rev. 4:245-273
Wilk S., et al. (1993) Enz. Prot. 47:306-313