I-120

Material Data Sheet

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Price: $985.00
Catalog #: I-120

Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Price: 
$985 $245
Quantity: 
200 µg, 1 mg

This peptide boronic acid is structurally similar to the peptide aldehyde MG-132 and also inhibits the chymotrypsin-like peptidase activity of the proteasome, but with much higher potency. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.

Product Information

Structure: 
Purity: 
95% by HPLC. Structure confirmed by <sup>1</sup>H-NMR.
Solubility: 
Soluble and stable in DMSO up to 15 mg/ml.
Activity: 

Ki = 0.023 nM vs. SDS-activated 20S Proteasome.

Use & Storage

Use: 

Highly potent and selective cell-permeable inhibitor of the proteasome.

Storage: 
Store at -20°C. Avoid multiple freeze/thaw cycles.

Literature

References: 

Adams J., et al. (1998) Bioorg. Med. Chem. Lett. 8:333-338
Lee D.H. and Goldberg A.L. (1998) Tren. Cell. Biol. 8:397-403
McCormack T.A. et al, (1998) Biochem. 37:7792-7800
Myung J., et al. (2001) Med. Res. Rev. 4:245-273
Wilk S., et al. (1993) Enz. Prot. 47:306-313