I-110

Material Data Sheet

Epoxomicin

Price: $665.00
Catalog #: I-110

Epoxomicin

Price: 
$665 $265
Quantity: 
200 µg, 1 mg
Data Sheet: 

Cell-permeable, potent, selective and irreversible proteasome inhibitor initially isolated as natural product from an Actinomycetes strain. Predominantly inhibits the chymotrypsin-like activity of the proteasome.

Product Information

Structure: 
Purity: 
> 95% by HPLC. Structure confirmed by H-NMR.
Solubility: 
Soluble and stable in DMSO up to 15 mg/ml.
Activity: 

kobs/[I] = 25,000 M-1 s-1 versus 20S proteasome.

Literature

References: 

Kim K.B., et al. (1999) Bioorgan. Med. Chem. Lett. 9:3335-3340
Sin N., et al. (1999) Bioorgan. Med. Chem. Lett. 9:2283-2288