I-110

Material Data Sheet

Epoxomicin

Price: $300.00

Catalog #: I-110

Epoxomicin

Price:

$300

Quantity:

200 μg

Data Sheet:

110_epox.pdf

Structure:

Purity:

95% by HPLC. Structure confirmed by <sup>1</sup>H-NMR.

Solubility:

Soluble and stable in DMSO up to 15 mg/ml.

Activity:

k_obs/[I] = 25,000 M^-1 s^-1 versus 20S proteasome.

Cell-permeable, potent, selective and irreversible proteasome inhibitor initially isolated as natural product from an Actinomycetes strain. Predominantly inhibits the chymotrypsin-like activity of the proteasome.

Literature

References:

Kim K.B., et al. (1999) Bioorgan. Med. Chem. Lett. 9:3335-3340
Sin N., et al. (1999) Bioorgan. Med. Chem. Lett. 9:2283-2288