Material Data Sheet
Quantity:200 µg, 1 mg
Cell-permeable, potent, selective and irreversible proteasome inhibitor initially isolated as natural product from an Actinomycetes strain. Predominantly inhibits the chymotrypsin-like activity of the proteasome.
Purity:> 95% by HPLC. Structure confirmed by H-NMR.
Solubility:Soluble and stable in DMSO up to 15 mg/ml.
kobs/[I] = 25,000 M-1 s-1 versus 20S proteasome.
Kim K.B., et al. (1999) Bioorgan. Med. Chem. Lett. 9:3335-3340
Sin N., et al. (1999) Bioorgan. Med. Chem. Lett. 9:2283-2288