E3-521

New
Material Data Sheet

SKP1/SKP2 Complex

Price: $285.00
Catalog #: E3-521

SKP1/SKP2 Complex

Price: 
$285
Quantity: 
25 µg
Data Sheet: 

SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.   SKP1 is the adapter protein that links Cullin-1 to various F-box proteins (such as SKP2) that serve as the substrate recognition components of SCF ligases.  SKP2 targets include proteins involved in cell cycle progression and signal transduction. SKP2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in G1/S transition in a CKS1-dependent process.  This recombinant protein is untagged.

Product Information

Stock: 
X mg/ml (X µM) in 50 mM HEPES pH 7.5, 150 mM NaCl, 10% (v/v) Glycerol, 1 mM DTT
MW: 
19 kDa (SKP1), 48 kDa (SKP2)
Purity: 
> 85% by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue stain
Host: 
Human Recombinant
Storage: 

Store at -80°C.  Avoid multiple freeze/thaw cycles.