E3-300
Livin β/BIRC7 isoform 1
Livin β/BIRC7 isoform 1
Livin α and Livin β are two splice variants generated from the Baculoviral IAP repeat-containing protein 7 (BIRC7) gene. Livin is a member of the Inhibitor of Apoptosis Protein (IAP) family that contains a single baculovirus IAP repeat (BIR) and a C-terminal RING domain. Livin exerts an anti-apoptotic activity by inhibiting caspase's 3, 7, and 9, and by its E3 Ubiquitin ligase activity. In vitro, Livin directly inhibits caspase 3 and proteolytic activation of pro-caspase 9, and ubiquitinates recombinant DIABLO. Livin ß is a splice variant that's 18 amino acids shorter in the BIR-RING linking region than the Livin α splice variant. This recombinant protein contains a C-terminal 6-His tag.
Product Information
Use & Storage
Recombinant Human Livin β is a Ubiquitin Ligase (E3) that functions downstream of a Ubiquitin-activating (E1) enzyme and a Ubiquitin-conjugating (E2) enzyme to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application.
Store at -80ºC and avoid multiple freeze/thaw cycles.