Also known as: His₆-hHR6B (human Homolog of RAD6B)

The human HR6A and HR6B proteins share about 95% amino acid sequence identity with each other and about 70% with yeast counterparts, but notably lack the acidic C-terminal domain found in S. cerevisiae RAD6. The RAD6 pathway is essential to post-replication repair of DNA and damage-induced mutagenesis in eukaryotic cells. hHR6 protein expression is cell cycle regulated and function with RAD5 and RAD18 RING-Finger proteins. The human proteins function similar to the yeast homologs, and may have additional roles in chromatin remodeling and spermatogenesis. This protein has an N-terminal His₆ tag, Accession NP_003328.