Material Data Sheet

OTUD7B/Cezanne, Catalytic Domain

Price: $195.00
Catalog #: E-563
OTUD7B/Cezanne, Catalytic Domain
50 µg
Data Sheet: 
OTU domain-containing protein 7B (OTUD7B), also known as cellular zinc finger anti-NF-kappa B (Cezanne), is a C64 type peptidase and a member of the ovarian tumor (OTU) protein super-family with a predicted molecular weight of 93 kDa. The human protein shares 90% amino acid sequence identity with its mouse ortholog. Cezanne has been reported to cleave K48-, and K63-linked poly-Ubiquitin chains, and also to display a preference for K11-linked chains. It has been shown to play a role in the negative regulation of NF-κB signaling, possibly by deubiquitination of RIPK1 and TRAF3. This untagged recombinant protein contains the catalytic domain (including the OTU domain) of Cezanne.

Product Information

50 mM Hepes pH 7.5, 100 mM NaCl, 10 % glycerol, and 1 mM TCEP
36 kDa

Use & Storage

Reaction conditions will need to be optimized for each specific application. We recommend an initial recombinant human Cezanne Catalytic Domain concentration of 0.1-1.0 µM.
Store at -80°C. Avoid multiple freeze/thaw cycles.
≥ 90% by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue Stain.



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Hu, H. et al. (2013) Nature 494: 371