E-506

Material Data Sheet

His6-USP2 Catalytic Domain

Price: $125.00
Catalog #: E-506

His6-USP2 Catalytic Domain

Price: 
$125
Quantity: 
50 µg

Also known as: His6-USP2CD (UBP41 catalytic domain)

USP2 (Ubiquitin Specific Protease 2) is a cysteine protease over-expressed in prostate cancer, is androgen-regulated and interacts with and prolongs the half-life of fatty acid synthase (FAS). FAS stabilization is associated with the malignancy of a subset of aggressive prostate cancers. Mdm2 is also a substrate for USP2 indicating that the enzyme may regulate p53-dependent pathways. The in vivo and in vitro oncogenic properties of USP2 are also linked to its deubiquitinating activity. It has been hypothesized that USP2 might stabilize short-lived proteins that accumulate and may act as regulators or effectors in the induction of apoptosis. This recombinant protein contains a C-terminal his-tag and residues 259-605 representing the catalytic domain (CD) of USP2. Accession # NP_004196.

Product Information

Stock: 
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 150 mM NaCl, 10% glycerol, 0.5 mM EDTA, 1mM DTT. Actual concentration varies with specific Lot #
MW: 
42 kDa
Purity: 
> 95% by SDS-PAGE

Literature

References: 

Baek S.H., et al. (1997) J.Biol.Chem. 272:25560-25565

Catanzariti A.M., et al. (2003) Canc.Res. 63:682-688

Graner E., et al. (2004) Canc.Cell. 3:253-261

Kwon-Yul R.,et al. (2006) Anal.Biochem. 353:153-155

Nijman S.M.B., et al. (2005) Cell. 123:773-786

Priolo C., et al. (2006) Canc.Res. 66:8625-8632

Renatus M., et al. (2006) Structure. 14:1293-1302

Tirat A., et al. (2005) Anal.Biochem. 343:244-255

Nijman S.M.B., et al. (2005) Cell. 123:773-786

Ventadour S., et al. (2007) J.Biol.Chem. 282:5302-5309