Material Data Sheet

USP2 Catalytic Domain

Price: $129.00
Catalog #: E-504

USP2 Catalytic Domain

50 µg
Data Sheet: 

USP2 (Ubiquitin Specific Protease 2) is a cysteine protease over-expressed in prostate cancer, is androgen-regulated and interacts with and prolongs the half-life of fatty acid synthase (FAS). FAS stabilization is associated with the malignancy of a subset of aggressive prostate cancers. Mdm2 is also a substrate for USP2 indicating that the enzyme may regulate p53-dependent pathways. The in vivo and in vitro oncogenic properties of USP2 are also linked to its deubiquitinating activity. It has been hypothesized that USP2 might stabilize short-lived proteins that accumulate and may act as regulators or effectors in the induction of apoptosis. This recombinant protein contains residues 259-605 representing the catalytic domain (CD) of USP2.

Product Information

 X mg/ml (X μM) in 50 mM HEPES pH 8.0, 200 mM NaCl, 0.5 mM EDTA, 1mM DTT 
40 kDa
> 95% by SDS-PAGE

Use & Storage


USP2 Catalytic Domain is a Ubiquitin-specific deconjugating enzyme.  Reaction conditions will need to be optimized for each specific application.  We suggest an initial USP2 Catalytic Domain concentration of 1-5 nM.


Store at -80°C. Avoid multiple freeze/thaw cycles.




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