Also known as: 19S Proteasome (PA700)

This highly purified 19S (PA700) proteasome preparation (from transformed HEK cells) can be used in vitro for the activation of 20S proteasome, as well as for deubiquitination of target substrates via associated DUBs, such as RPN11.  The 19S subunit is the ATP-dependant regulatory particle (RP) of the 26S proteasome (E-365), compromised also of a 20S core particle (CP)(E-350, E-360, E-370, E-375) that is responsible for the proteolytic degradation of short-lived and abnormal intracellular proteins. The 19S subunit can bind to one or both ends of the 20S core particle (CP), stimulating peptidase activity by modulating conformational changes and/or facilitating the access of substrates to the proteolytic 20S core.