AP-190

New
Material Data Sheet

TDP-43/TARDBP Protein

Price: $299.00
Catalog #: AP-190

TDP-43/TARDBP Protein

Price: 
$299.00
Quantity: 
100 µg
Data Sheet: 

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing.  TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration.  In these cases it is absent from the nucleus and accumulates--along with a truncated 20-28 kDa form--in the Ubiquitin-containing inclusion bodies.  TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis.  Human TDP-43 is 96% identical to the mouse ortholog.

Product Information

Stock: 
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 500 mM NaCl, 5 mM DTT, 20% (v/v) Glycerol, 0.4 M Urea
MW: 
45 kDa
Purity: 
>95% by SDS-PAGE under reducing conditions and visualized with Colloidal Coomassie Blue Stain.
Storage: 

Store at -80°C.  Avoid multiple freeze/thaw cycles.