Anti-UbcH10

Catalog #: A-650 UbcH10 is an essential mediator of mitotic destruction events and cell cycle progression. It catalyzes the destruction of cyclins A and B in conjunction with the anaphase-promoting complex. This activity is essential at the end of mitosis for the inactivation of their partner kinase Cdc2 and exit from mitosis into G1 of the next cell cycle.

Product Information

Quantity: 

200 μl

Price: 

$150

Stock: 

PBS pH 7.4, 20% glycerol.

Antigen: 

Full-length, highly purified human UbcH10 protein.

Use & Storage

Storage: 

Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.

Specificity: 

Recommended dilution range for Western blot analysis is 1:100 to 1:1000. Non-functional for immunoprecipitation.

Literature

References: 

Bastians H., et al. (1999) Mol. Biol. Cell. 10:3927-3941
Hershko A. and Ciechanover A. (1998) Ann. Rev. Biochem. 67:425-479
Lin Y., et al. (2002) J. Biol. Chem. 277:21913-21921
Okamoto Y., et al. (2003) Canc. Res. 63:4167-4173
Townsley F.M., et al. (1997) Proc. Natl. Acad. Sci. 94:2362-2367