A-650

Material Data Sheet

UbcH10/UBE2C

Price: $159.00
Catalog #: A-650

UbcH10/UBE2C

Price: 
$159
Quantity: 
200 µL
UbcH10 is an essential mediator of mitotic destruction events and cell cycle progression. It catalyzes the destruction of cyclins A and B in conjunction with the anaphase-promoting complex. This activity is essential at the end of mitosis for the inactivation of their partner kinase Cdc2 and exit from mitosis into G1 of the next cell cycle.

Product Information

Stock: 
PBS pH 7.4, 20% glycerol.
Antigen: 
Full-length, highly purified human UbcH10 protein.

Use & Storage

Use: 

Recommended dilution range for Western blot analysis is 1:100 to 1:1000. Non-functional for immunoprecipitation.

Storage: 

Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.

Literature

References: 

Bastians H., et al. (1999) Mol. Biol. Cell. 10:3927-3941
Hershko A. and Ciechanover A. (1998) Ann. Rev. Biochem. 67:425-479
Lin Y., et al. (2002) J. Biol. Chem. 277:21913-21921
Okamoto Y., et al. (2003) Canc. Res. 63:4167-4173
Townsley F.M., et al. (1997) Proc. Natl. Acad. Sci. 94:2362-2367