A-645

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Material Data Sheet

UbcH9/UBE2E3 Polyclonal Ab

Price: $150.00
Catalog #: A-645

UbcH9/UBE2E3 Polyclonal Ab

Price: 
$150
Quantity: 
200 μl
Data Sheet: 
application/pdf iconA-645_antiH9.pdf
Stock: 

PBS pH 7.4.

Antigen: 
Full-length, highly purified human UbcH9 protein.
UBE2I (Ubc9) is a member of the E2 family and is homologous to ubiquitin-conjugating enzymes, but is specific for the conjugation of SUMO to a variety of target proteins. This E2 is unusual in that it interacts directly with protein substrates that are modified by SUMOylation, and may play a role in substrate recognition. UbcH9 can mediate the conjugation of SUMO-1, SUMO-2 and SUMO-3 to a variety of proteins including RanGAP1, IκBα, and PML without the requirement of an E3 ligase.
Storage: 
Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.
Specificity: 
Recommended dilution range for Western blot analysis is 1:100 to 1:1000.</p>

Literature

References: 

Desterro J.M., et al. (1999) J. Biol. Chem. 274:10618-24
Joana M.P, et al. (1997) FEBS. Lett. 417:3168-3179
Johnson E.S and Blobel G. (1997) J. Biol. Chem. 272:26799-26794
Ito K., et al. (1999) Cytogenet. Cell. 84:99-104
Liu Q., et all. (1999) J. Biol. Chem. 274:16979-16987
Matushewski K., et al. (1996) J. Biol. Chem. 271:2789-2794
Sampson D.A., et al. (2001) J. Biol. Chem. 276:21664-21669
Sampson D.A., et al. (2001) J. Biol. Chem. 276:21664-21669
Tatham M.H., et al. (2003) Biochem. 42:3168-3179