A-450

Material Data Sheet

Anti-p23/PTGES3

Price: $159.00
Catalog #: A-450

Anti-p23/PTGES3

Price: 
$159
Quantity: 
50 µg
Data Sheet: 

Prostaglandin E Synthase 3 (also known as Cytosolic prostaglandin E2 synthase, HSP90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, or p23) is a glutathione-dependent enzyme found in the cyclooxygenase-1-mediated PGE2 biosynthetic pathway.  This protein is highly conserved in eukaryotes and in humans it is expressed in most tissues other than striated muscle.  Through its prostaglandin synthase activity, p23 contributes to the production of prostaglandin E2 and has a role in maintenance of tissue homeostasis.  In addition to its catalytic activity in the prostaglandin biosynthesis pathway, p23 serves as a co-chaperone to HSP90 (Heat Shock Protein 90) in various biological functions.  The p23/HSP90 complex is required for efficient telomerase assembly in vitro and in vivo.  It has also been demonstrated that p23 and HSP90 localize to genomic response elements in a hormone-dependent manner, and may promote disassembly of transcriptional regulatory complexes in response to changes in cellular signaling pathways.  p23 protein is up-regulated in several cancers, notably breast cancer.

Product Information

Stock: 
0.5 mg/ml in PBS pH 7.4, 50%  glycerol, 0.09% sodium azide
Antigen: 
Recombinant protein corresponding to full length human PTGES3.

Use & Storage

Use: 

Recommended dilution range for Western blot analysis is 1:2000.

Storage: 

Store at -20°C.

Literature

References: 

Freeman B.C. & Yamamoto K.R. (2002)  Science  296: 2232-2235

Forsythe H.L., et al. (2001) J. Biol. Chem.  276: 15571-15574

Patwardhan C.A., et al.  (2013)  J. Biol. Chem.  288: 7313-7325