A-340

Material Data Sheet

UCH-L1

Price: $159.00
Catalog #: A-340

UCH-L1

Price: 
$159
Quantity: 
200 µL
Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters from the C-terminus of ubiquitin. UCH-L1 is a member of the low molecular weight UCHs that processes ubiquitin precursors and ubiquitinated proteins to generate monomeric ubiquitin. The expression of UCH-L1 is highly specific to cells of the neuroendocrine system and their tumors. UCH-L1 variants (Ile93Met) have been linked to Parkinson disease and may participate in processes critical for neuronal health.

Product Information

Stock: 
PBS pH 7.4.
Antigen: 
Full-length, highly purified human UCHL1 protein.

Use & Storage

Use: 

Recommended dilution range for Western blot analysis is 1:100 to 1:1000.

Storage: 

Store unopened vial at -80°C. Avoid repeated freeze-thaw cycles. Aliquot antibody in small volumes prior to freezing.

Literature

References: 

Day I.N., et al. (1990) Biochem J. 268:521-524
Dang L.C. et al. (1998) Biochem. 37:1868-1879
Johnston S.C., et al. (1999) EMBO.J. 18:3877-3887
Kurihara L.J., et al. (2001) Hum. Mol. Genet. 10:1963-1970
Leroy E., et al. (1998) DNA.Res. 5:397-400
Mayer A.N. and Wilkinson K.D. (1989) Biochem. 28:166-172
Pickart C.M., et al. (1985) J.Biol.Chem. 260:7903-7910
Saigoh K., et al. (1999) Nat. Genet. 23:47-51