3093

Material Data Sheet

Dorsomorphin dihydrochloride

Price: $185.00
Catalog #: 3093

Dorsomorphin dihydrochloride

Price: 
$175 $735
Quantity: 
10 mg 50 mg

Product Information

MW: 
472.41
Purity: 
>98%
Solubility: 
Soluble to 100 mM in water and to 10 mM in DMSO
Activity: 

 

Potent and selective inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and metformin (Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitroShown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Storage: 
Desiccate at RT

Literature

References: 

 

Zhou et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J.Clin.Invest. 108 1167. PMID: 11602624.

Hao et al (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 3 2904. PMID: 18682835.

Yu et al (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat.Chem.Biol.4 33. PMID: 18026094.

Vucicevic et al (2011) Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7 40. PMID: 20980833.