2706

Material Data Sheet

Temozolomide

Price: $89.00
Catalog #: 2706

Temozolomide

Price: 
$85 $339
Quantity: 
10 mg, 50 mg
Data Sheet: 

Alternative Names: NSC 362856, CCRG 81045

Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5­,1-d]-1,2,3,5-tetrazine-8-carboxamide

Biological Activity

DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells.

Product Information

MW: 
194.15
Purity: 
>99%
Solubility: 
Soluble to 50 mM in DMSO
Storage: 
Store at RT

Literature

References: 

Plowman et al (1994) Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 54 3793. PMID: 8033099.

Clark et al (1995) Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. J.Med.Chem. 38 1493. PMID: 7739008.

Bodell et al (2003) Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors. Cancer Epidemiol.Biomarkers Prevent. 12 545.

Kanzawa et al (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11 448. PMID: 14713959.