Material Data Sheet
Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo.
Solubility:Soluble in ethanol and DMSO
Use & Storage
Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect.
Store stock solution at -20°C. Avoid multiple freeze/thaw cycles.
Waring and Beaver (1996) Gen.Pharmacol. 27: 1311
Fitzpatrick, et al (2000) Dig.Dis.Sci. 45: 2327
Vigushin, et al (2004) Med.Oncol. 21: 21