2163

Material Data Sheet

Z-VAD-FMK

Price: $219.00
Catalog #: 2163

Z-VAD-FMK

Price: 
$209
Quantity: 
1 mg
Data Sheet: 

Product Information

MW: 
467.49
Solubility: 
Soluble to 9.35 mg/ml in DMSO
Activity: 

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Storage: 
Store at -20°C

Literature

References: 

 

Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21. PMID: 8670109.

Kunstle et al (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 55 5. PMID: 9093874.

Garcia-Calvo et al (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 273 32608. PMID: 9829999.

King et al (1998) Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 12 1553. PMID: 9766499.