1544

Material Data Sheet

(±)-Bay K 8644

Price: $165.00
Catalog #: 1544

(±)-Bay K 8644

Price: 
$159 $655
Quantity: 
10 mg, 50 mg
Data Sheet: 

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-­[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Biological Activity

L-type Ca2+-channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. Separate enantiomers (R)-(+)-Bay K 8644 and (S)-(-)-Bay K 8644 also available (Cat. Nos. 1545 and 1546 respectively). In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

Product Information

MW: 
356.3
Purity: 
>99%
Solubility: 
Soluble to 100 mM in ethanol
Storage: 
Store at +4°C

Literature

References: 

Greenberg et al (1984) Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res. 305 365. PMID: 6204725.

Bourson et al (1989) Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur.J.Pharmacol. 160 339. PMID: 2469593.

Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3 568. PMID: 18983970.

Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46. PMID: 18636076.