1391

Material Data Sheet

NF 449

Price: $199.00
Catalog #: 1391

NF 449

Price: 
$189 $795
Quantity: 
10 mg 50 mg
Data Sheet: 

Product Information

MW: 
1505.06
Solubility: 
Soluble to 50 mM in water
Activity: 

 

Potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivoAlso acts as a Gsα-selective antagonist.

Storage: 
Store at RT

Literature

References: 

 

Hohenegger et al (1998) G-selective G protein antagonists. Proc.Natl.Acad.Sci.U.S.A. 95 346. PMID: 9419378.

Hechler et al (2005) Inhibition of platelet functions and thrombosis through selective or non-selective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4",4'"-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J.Pharmacol.Exp.Ther. 314 232. PMID:15792995.

Rettinger et al (2005) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology. 48 461. PMID: 15721178.

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.