1232

Material Data Sheet

Wortmannin

Price: $89.00
Catalog #: 1232

Wortmannin

Price: 
$85 $319
Quantity: 
1 mg 5 mg
Data Sheet: 

Product Information

MW: 
428.44
Solubility: 
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Activity: 

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

Storage: 
Desiccate at -20°C

Literature

References: 

Arcaro and Wymann (1993) Wortmannin is a potent phophatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem.J. 296 297. PMID: 8257416.

Powis et al (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 542419. PMID: 8162590.

Schultz et al (1995) In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor wortmannin. Anticancer Res. 15 1135. PMID: 7653991.

Liu et al (2005) Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem.Biol. 12 99. PMID: 15664519.